RESUMO
The efficacy was studied of using allopurinol in 68 patients with primary podagra. The obtained results were compared with the treatment of 118 other patients who received similar treatment but without allopurinol (zanthinoxidase inhibitor). Allopurinol increased essentially the efficacy of therapeutic measures though positive dynamics concerning the renal process was achieved in 1/3 of patients.
Assuntos
Alopurinol/uso terapêutico , Gota/tratamento farmacológico , Nefropatias/tratamento farmacológico , Adulto , Idoso , Alopurinol/farmacocinética , Animais , Modelos Animais de Doenças , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Gota/metabolismo , Humanos , Nefropatias/metabolismo , Masculino , Pessoa de Meia-Idade , Ratos , Fatores de TempoRESUMO
The efficacy of isolated and combined treatment of renal lesions sallopurionol (milurit), potassium orotate, azathioprin (6-mercaptopurin) was studied in 207 inpatients with primary podagra. Citrate mixtures, urinary antiseptic and hypotensive agents were used when indicated. Follow-up results from 1 to 12 years are analyzed. Prolonged systematic complex treatment of podagric nephropathy is medically and economically effective.