RESUMO
Suppressor status of immunity in 34 patients with gastric cancer of the III-IV stages was studied before and after (15 days and 3 months) gastrectomy and gastrosplenectomy. The control group consisted of 42 healthy donors. It was shown that gastrectomy caused inhibition of the endogenous activity, but stimulated the function of the prostaglandin-producing suppressor cells while combined gastrosplenectomy induced inhibition of the function of both endogenous and prostaglandin-producing suppressor cells.
Assuntos
Adenocarcinoma Mucinoso/imunologia , Adenocarcinoma/imunologia , Carcinoma/imunologia , Gastrectomia , Esplenectomia , Neoplasias Gástricas/imunologia , Linfócitos T Reguladores/imunologia , Adenocarcinoma/cirurgia , Adenocarcinoma Mucinoso/cirurgia , Carcinoma/cirurgia , Humanos , Imunoglobulinas/análise , Contagem de Leucócitos , Linfoma não Hodgkin/imunologia , Linfoma não Hodgkin/cirurgia , Período Pós-Operatório , Baço/imunologia , Neoplasias Gástricas/cirurgiaRESUMO
The paper discusses data on combined T-activin and cytostatic drug treatment of 9 cases of extensive cancer of the kidney and 9 cases of disseminated malignant tumor of the testicle. An immunomodulating effect of T-activin was shown.
Assuntos
Neoplasias Renais/tratamento farmacológico , Peptídeos/uso terapêutico , Neoplasias Testiculares/tratamento farmacológico , Extratos do Timo/uso terapêutico , Adjuvantes Imunológicos/uso terapêutico , Alopurinol/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Bleomicina/administração & dosagem , Cisplatino/administração & dosagem , Fluoruracila/administração & dosagem , Humanos , Masculino , Vimblastina/administração & dosagemAssuntos
Artrite Juvenil/imunologia , Linfócitos T , Adolescente , Criança , Pré-Escolar , Humanos , Contagem de LeucócitosRESUMO
The levels of T-lymphocytes in untreated lymphoid malignancies in children and those after different schemes of chemoimmunotherapy were compared. The ratio of T-helper and T-suppressor cells changed in the course of treatment in correlation with the chemotherapeutic effect: the fraction of T mu cells practically did not change whereas the T gamma cell fraction decreased considerably in patients who revealed a good response to therapy. BCG treatment stimulated both populations but the response of T gamma cells was stronger. Transplantation of thymus was followed by an increase on T mu cells.
