Biomimetic Synthesis of an Antiviral Cinnamoylphloroglucinol Collection from Cleistocalyx operculatus: A Synthetic Strategy Based on Biogenetic Building Blocks.

A synthetic strategy based on biogenetic building blocks for the collective and divergent biomimetic synthesis of cleistoperlones A-F, a cinnamoylphloroglucinol collection discovered from Cleistocalyx operculatus, has been developed. These syntheses proceeded successfully in only six to seven steps starting from commercially available 1,3,5-benzenetriol and involving oxidative activation of stable biogenetic building blocks as a crucial step. Key features of the syntheses include a unique Michael addition/ketalization/1,6-addition/enol-keto tautomerism cascade reaction for the construction of the dihydropyrano[3,2-d]xanthene tetracyclic core of cleistoperlones A and B, and a rare inverse-electron-demand hetero-Diels-Alder cycloaddition for the establishment of benzopyran ring in cleistoperlones D-F. Moreover, cleistoperlone A exhibited significant antiviral activity against acyclovir-resistant strains of herpes simplex virus type 1 (HSV-1/Blue and HSV-1/153).

Low noise, self-phase-modulation-enabled femtosecond fiber sources tunable in 740-1236†nm for wide two-photon fluorescence microscopy applications.

We have demonstrated widely tunable Yb:fiber-based laser sources, aiming to replace Ti:sapphire lasers for the nJ-level ultrafast applications, especially for the uses of nonlinear light microscopy. We investigated the influence of different input parameters to obtain an expansive spectral broadening, enabled by self-phase modulation and further reshaped by self-steepening, in the normal dispersion regime before the fiber damage. We also discussed the compressibility and intensity fluctuations of the demonstrated pulses, to reach the transform-limited duration with a very low intensity noise. Most importantly, we have demonstrated clear two-photon fluorescence images from UV-absorbing fluorophores to deep red dye stains.

An epidemiological survey of febrile convulsions among pupils in the Wenzhou region / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To study the prevalence and clinical features of febrile convulsion (FC) among pupils in the Wenzhou region, Zhejiang Province, China.</p><p><b>METHODS</b>Using a random stratified cluster sampling method, 6406 children under 12 years from two primary schools of urban areas and two primary schools of rural areas were surveyed.</p><p><b>RESULTS</b>The prevalence of FC was 3.67% (235/6406). Most children (75.7%) experienced their first onset of FC at 6 months to 3 years of age (median: 16 months). The seizures were generalized (95.3%, 224/235), with a duration of less than 10 minutes (86.4%, 203/235). FC was developed into epilepsy in 13 children (5.5%) who all suffered from complex FC. Relapses were noted in 88 cases (37.4%), among whom 38 patients had only 1 recurrence and 50 patients had 2 or more relapses. EEG was performed in 200 cases, among whom 12(6.0%) showed abnormalities.</p><p><b>CONCLUSIONS</b>The prevalence of FC is 3.67% among pupils in the Wenzhou region. The seizures are generalized, with a short duration. A part of complex FC can be developed into subsequent epilepsy.</p>

Unilateral spatial neglect in children with attention deficit hyperactivity disorder / 中华儿科杂志

<p><b>OBJECTIVE</b>To detect unilateral spatial neglect phenomenon in children with attention deficit hyperactivity disorder (ADHD) and to test the hypothesis that the phenomenon is associated with ADHD.</p><p><b>METHODS</b>Thirty two boys met with ADHD diagnostic criteria of DSM-IV(TM) (ADHD group) and the 32 healthy boys without ADHD as control group participated in this study. All the participants received the flowing managements. The spatially sensitive tools of the Line Bisection test and the Star Cancellation test and some general measures (non-spatial) were used to evaluate spatial attention.</p><p><b>RESULTS</b>(1) The score of Line Bisection test of boys with ADHD was (-9.37 +/- 6.57), and that of the control group was (-5.46 +/- 4.69), the difference between two groups was significant (t = -2.735, P < 0.01); the difference in left side score of the Star Cancellation test was statistically significant (t = -3.78, P < 0.01) in the ADHD group versus the control group (11.44 +/- 5.55 vs. 16.34 +/- 4.82), and the left side score was also lower than the right side one (17.13 +/- 6.36), the difference was significant (t = -3.09, P < 0.01). (2) Both groups' scores of the Line Bisection test were biased to the right side of "0" value respectively (ADHD group: t = -8.064, P < 0.01; control group: t = -6.585, P < 0.01), each side of which was lower versus "expected value" "27/27" on right side (ADHD group: t = -8.78, P < 0.01; control group: t = -7.39, P < 0.01) and left side (ADHD group: t = 15.85, P < 0.01; control group: t = -12.52, P < 0.01).</p><p><b>CONCLUSIONS</b>The results suggest that left spatial neglect may be a common general phenomenon of school age boys. Compared with normal children, children with ADHD may have obvious left spatial neglect, which suggest that there be a common neurophysiologic mechanism between left spatial bias and ADHD.</p>

Diagnostic Value of Video-Electroencephalogram in Children with Sleeping-Related Seizure Disorders / 实用儿科临床杂志

Objective To evaluate the diagnostic and differentiable value of video-electroencephalogram(VEEG)in sleeping-related seizure disorder.Method Sixty-five cases with sleeping-related seizure disorders(35 suspected epilepsy and 30 suspected non-epileptic seizure)enrolled in our clinics from Jan.2005 to Jun.2006 were examined by VEEG and EEG.Results Among 35 children suspected to have the possibility of epilepsy,the epileptic discharge rate examined with VEEG was 62.86%(22/35),which were significantly higher than that by EEG was 17.14%(6/35)(P

Expressions of Neuron-Specific Enolase and Tumor Necrosis Factor-? Concentrations of Serum and Cerebrospinal Fluid in Children with Epilepsy and Its Significances / 实用儿科临床杂志

Objective To explore the levels of neuron-specific enolase(NSE) and tumor necrosis factor-?(TNF-?)concentrations of serum and cerebrospinal fluid(CSF) in children with epilepsy,and evaluate its relationships with neuronal damage.Methods Sixty-two epilepsy children were divided into 2 groups:severe group including 28 cases of frenquent seizures ≥3 vices or time of master single test seizures≥15 min,mild group including 34 cases of infrenquent seizures