Simulation and mechanism for the Ultrasound-Assisted Oiling-Out Process: A case study using Fructose-1,6-diphosphate.

Liquid-liquid separation, commonly referred to as oiling-out, frequently can occurs during crystallization, especially the anti-solvent crystallization process of phosphoryl compounds, and poses potential hurdle for high-quality product. Efficiently regulating oiling-out during crystallization remains a significant challenge. Among various techniques, ultrasound emerges as a green and effective approach to enhance the crystallization process. However, there is a dearth of in-depth research exploring the microscopic mechanisms of this process. Therefore, our research focused on the fructose-1,6-diphosphate (FDP), a typical phosphoryl compound, to gain a deeper understanding of how ultrasound influences the oiling-out process. The focused beam reflectance measurement (FBRM) technology was used to investigate the oiling-out phenomenon of FDPNa3 across various solvent ratios. In addition, the influence of ultrasound on the induction time was studied and the nucleation energy barrier was calculated. Finally, to further unravel the microscopic mechanisms, we utilized molecular simulation techniques to analyze the impact of ultrasound power on the dissolution-precipitation process. Our observations revealed a consistent oiling-out process that attainted a stable state regardless of the solvent employed. Notably, the results of the oiling-out induction time experiments indicated that ultrasound significantly reduced helped lower the nucleation energy barrier of FDP3- ions, thereby dismantling FDP3-clusters in solution. Thus, in turn, shortened the reduced induction time and promoted crystallization. Furthermore, ultrasound reduced the interactions between FDP3-ions and water molecules as well as FDP3- ions themselves. As simulated field intensity increased, these interaction forces gradually diminished, the thickness of the hydration layer surrounding the FDP3- clusters facilitating the disruption of clusters, ultimately enhancing the crystallization process.

Can internet use change sport participation behavior among residents? Evidence from the 2017 Chinese General Social Survey.

Purpose: The popularization of the internet has promoted the implementation of China's national fitness strategy and created conditions for Chinese residents to participate in sports. The internet is an essential medium for disseminating sports knowledge, and the use of the internet can change sport participation behaviors. Therefore, the internet can be used to popularize sports knowledge and promote the participation of all people in sports and thus improve the health of the entire population. This study attempts to empirically analyse how the use of the internet changes sport participation behavior. Method: Utilizing data from the 2017 China General Social Survey, a probit model, ivprobit model, and bias-corrected non-parametric percentile bootstrap test were used to analyse the impact of internet use on sport participation behavior. Results: The empirical results show that internet use significantly increased the probability of participation in sports by Chinese residents. Heterogeneity test results showed that internet use was more effective in promoting sport participation in middle-aged groups, groups of older persons, unmarried groups, and groups with a high school education or above. The mediating effect test results showed that internet use influenced residents' participation in sports by promoting social interaction, leisure and entertainment, and learning and recharging. Conclusions: The internet has changed participation in sports; specifically, the use of the internet promotes sport participation. Additionally, internet use has a more obvious impact on improving the sport participation behavior of middle-aged, older, unmarried, and middle- and higher-educated individuals. Internet social interaction, internet entertainment and internet learning are effective channels to encourage Chinese residents to participate in sports and improve their health.

The influence of air pollution on residents' outdoor exercise participation behaviour: Evidence from China Family Panel Studies.

Using data from China Family Panel Studies (CFPS) and based on the Probit and Tobit models, this study investigates the impact of air pollution on residents' outdoor exercise behaviour from the microscopic level. Specifically, this study examined the effects of PM2.5 index changes on residents' decision to participate in outdoor exercise and the duration of outdoor exercise participation. The empirical results show that the increase of PM2.5 index has a significant inhibitory effect on residents' participation in outdoor exercise, and has passed the robustness test and endogeneity test. Further testing found that the inhibitory effect was significantly different between urban and rural areas, and in the central, north-eastern and western regions where economic development was relatively backward, the conclusion that air pollution inhibited residents' outdoor exercise behaviour still holds true. However, the level of air pollution had no significant effect on the outdoor exercise behaviour of residents in the eastern region. So, while air pollution discourages residents from participating in outdoor exercise, the results are more applicable to less economically developed areas.

Socioeconomic Disparities in Health Care Consumption: Using the 2018-China Family Panel Studies.

The existing research on residents' health care consumption mostly covers medical care consumption and seldom regards residents' health care consumption as an independent research object. This article takes residents' healthcare consumption as the research object and aims to explore the impact of socioeconomic status on healthcare consumption and its mechanisms. The data of this study came from the 2018-China Family Panel Studies (CFPS). The binary probit regression model and the Tobit model explored the impact mechanism of residents' income, education, occupation, and physical activity on health care consumption decision-making and health care expenditure, respectively. The research results showed that, from the perspective of the direct influence mechanism, residents' work income (0.029, p < 0.01) and education level (811.149, p < 0.01) had a significant positive impact on health care consumption. Residents whose occupations (−99.697, p < 0.01) tend to be more skilled and also have higher health care consumption. From the perspective of the mediating mechanism, residents' physical exercise duration had a significant positive impact on their participation in healthcare consumption (0.005, p < 0.01) but had a weaker impact on healthcare consumption expenditure (21.678, p < 0.1). In general, socioeconomic status represented by income, education, and occupation had a significant positive impact on residents' health care consumption. The duration of physical exercise also played an important mediating role.

Can school health education improve students' physical exercise time? Empirical research based on CEPS (2014-2015) survey data.

Purpose: School health education is an effective strategy for cultivating adolescent physical exercise habits by transmitting healthy knowledge; it helps to form healthy behaviours and encourages students to participate in physical exercise. The purpose of this study was to explore the relationship between school health education and student participation in physical exercise. Methods: CEPS (China Education Penal Survey, 2014-2015) survey data were used to empirically analyse the impact of school health education on the time that students spend on physical exercise and the underlying mechanism of influence. Results: The results showed that receiving a school health education increased the time that students spent on physical exercise. 1) Compared with receiving health education in only primary school or secondary school, receiving health education in both primary and secondary school had a greater impact on students spending time on physical exercise. 2) Receiving a school health education improved the time that students spend on physical exercise by improving students' health perception and their sports interests. 3) Receiving a school health education had a more obvious impact on the physical exercise time of male students, nonrural resident students, and students from multi-child households. These findings can provide a reference for the seasonable settings of health education curriculum in schools.

Anticancer activity of Amauroderma rude.

More and more medicinal mushrooms have been widely used as a miraculous herb for health promotion, especially by cancer patients. Here we report screening thirteen mushrooms for anti-cancer cell activities in eleven different cell lines. Of the herbal products tested, we found that the extract of Amauroderma rude exerted the highest activity in killing most of these cancer cell lines. Amauroderma rude is a fungus belonging to the Ganodermataceae family. The Amauroderma genus contains approximately 30 species widespread throughout the tropical areas. Since the biological function of Amauroderma rude is unknown, we examined its anti-cancer effect on breast carcinoma cell lines. We compared the anti-cancer activity of Amauroderma rude and Ganoderma lucidum, the most well-known medicinal mushrooms with anti-cancer activity and found that Amauroderma rude had significantly higher activity in killing cancer cells than Ganoderma lucidum. We then examined the effect of Amauroderma rude on breast cancer cells and found that at low concentrations, Amauroderma rude could inhibit cancer cell survival and induce apoptosis. Treated cancer cells also formed fewer and smaller colonies than the untreated cells. When nude mice bearing tumors were injected with Amauroderma rude extract, the tumors grew at a slower rate than the control. Examination of these tumors revealed extensive cell death, decreased proliferation rate as stained by Ki67, and increased apoptosis as stained by TUNEL. Suppression of c-myc expression appeared to be associated with these effects. Taken together, Amauroderma rude represented a powerful medicinal mushroom with anti-cancer activities.