Information Seeking and Receiving of Older Adults with Diabetes in the Online Health Community: An Information Need Contextualization Perspective.

Online health communities (OHCs) are important online health communication channels for older adults with diabetes to access health information. When seeking health information, they often disclose a variety of contextual information (e.g., socio-economic situations) in their questions. Selective contextual information disclosure is a type of communication strategy for users in OHCs to elicit replies from others. In this study, we adopted text analysis to investigate what contextual information older adults with diabetes disclose to articulate their information needs and used the fixed-effect Poisson model to examine the relationships between different types of contextual information disclosure and informational support receipt. Our analyses were based on a dataset of 4,505 questions and corresponding replies from an online diabetes community. The results showed that cognitive information is the most frequently disclosed contextual information, while older adults tend to disclose demographic information in their questions less. Providing demographic and situational details in questions can enhance informational support receiving, resulting in an increased number of informational supports. However, disclosing cognitive, affective, informational channels, or support information does not significantly affect the informational support receiving. These findings can contribute to extending our existing understanding of information seekers' communication strategies in OHCs.

How CEO Workaholism Influences Firm Performance: The Roles of Collective Organizational Engagement and TMT Power Distance.

Based on upper echelons theory, the current study examines how and under what conditions CEO workaholism influences firm performance. Specifically, we propose that CEO workaholism is positively related to collective organizational engagement, which has a subsequent positive effect on firm performance. Top management team (TMT) power distance would moderate the relationship between CEO workaholism and collective organizational engagement in such a way that workaholic CEOs are more likely to stimulate collective organizational engagement when TMTs have a high level of power distance. Findings based on multi-source, multi-wave data from a sample of 122 CEOs in state-owned enterprises and their corresponding TMT members supported the hypotheses. This study is an initial attempt to empirically examine the effects of leader workaholism at the firm level, which answers the call for more research into the intersection of workaholism and leadership and carries implications for organizational management practices.

Vibration Control of Time-Varying Delay under Complex Excitation.

The existing available research outcomes on vibration attenuation control for time-delay feedback indicate that, for the delay dynamic vibration absorber with fixed time-delay control parameters, under harmonic excitation, a good vibration attenuation control effect occurs on the vibration of the main system. However, the effect is not obvious for complex excitation. Aiming at the above problems, in a short time interval, a harmonic excitation with the same displacement size as the complex excitation was established. Then, by calculating its equivalent amplitude and equivalent frequency, a harmonic equivalent method for complex excitation was proposed in this paper. The time-delay parameters were adjusted according to the equivalent frequency of harmonic equivalent excitation in real time; therefore, a good vibration attenuation control effect was obtained through the delay dynamic vibration absorber in the discrete time interval. In this paper, research on a time-varying delay dynamic vibration absorber was conducted by taking the two-degree-of-freedom vibration system with a delay dynamic vibration absorber as an example. The simulation results show that the proposed control method can reduce the vibration of the main system by about 30% compared with the passive vibration absorber. This can obviously improve the performance of the time-delay dynamic vibration absorber. It provides a new technical idea for the design of vehicle active frame system.

Propylene glycol-embodying deformable liposomes as a novel drug delivery carrier for vaginal fibrauretine delivery applications.

The purpose of this work was to develop and characterize the fibrauretine (FN) loaded propylene glycol-embodying deformable liposomes (FDL), and evaluate the pharmacokinetic behavior and safety of FDL for vaginal drug delivery applications. FDL was characterized for structure, particle size, zeta potential, deformability and encapsulation efficiency; the ability of FDL to deliver FN across vagina tissue in vitro and the distribution behavior of FN in rat by vaginal drug delivery were investigated, the safety of FDL to the vagina of rabbits and rats as well as human vaginal epithelial cells (VK2/E6E7) were also evaluated. Results revealed that: (i) the FDL have a closed spherical shape and lamellar structure with a homogeneous size of 185±19nm, and exhibited a negative charge of -53±2.7mV, FDL also have a good flexibility with a deformability of 92±5.6 (%phospholipids/min); (ii) the dissolving capacity of inner water phase and hydrophilicity of phospholipid bilayers of deformable liposomes were increased by the presence of propylene glycol, this may be elucidated by the fluorescent probes both lipophilic Nile red and hydrophilic calcein that were filled up the entire volume of the FDL uniformly, so the FDL with a high entrapment capacity (were calculated as percentages of total drug) for FN was 78±2.14%; (iii) the permeability of FN through vaginal mucosa was obviously improved by propylene glycol-embodying deformable liposomes, no matter whether the FN loaded in liposomes or not, although FN loaded in liposomes caused the highest permeability and drug reservoir in vagina; (iv) the FN mainly aggregated in the vagina and uterus, then the blood, spleen, liver, kidney, heart and lungs for vaginal drug delivery, this indicating vaginal delivery of FDL have a better 'vaginal local targeting effect'; and (v) the results of safety evaluation illustrate that the FDL is non-irritant and well tolerated in vivo, thereby establishing its vaginal drug delivery potential. These results indicate that the propylene glycol-embodying deformable liposomes may be a promising drug delivery carrier for vaginal delivery of fibrauretine.