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1.
Cells Tissues Organs ; 2023 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-37812928

RESUMO

BACKGROUND: An early substantial loss of basal forebrain cholinergic neurons (BFCNs) is a common property of Alzheimer's disease and the degeneration of functional BFCNs is related to learning and memory deficits. As a biocompatible and conductive scaffold for growth of neural stem cells, three-dimensional graphene foam (3D-GF) supports applications in tissue engineering and regenerative medicine. Although its effects on differentiation have been demonstrated, the effect of 3D-GF scaffold on the generation of BFCNs still remains unknown. METHODS: In this study, we used 3D-GF as a culture substrate for neural progenitor cells (NPCs) and demonstrated that this scaffold material promotes the differentiation of BFCNs while maintaining excellent cell viability and proliferation. RESULTS: Immunofluorescence analysis, RT-PCR, western blotting and ELISA revealed that the proportion of BFCNs at 21 days of differentiation reached approximately 30.5% on 3D-GF compared with TCPS group that only presented 9.7%. Furthermore, a cell adhesion study suggested that 3D-GF scaffold enhances the expression of adhesion proteins including vinculin, integrin and N-cadherin. These findings indicate that 3D-GF scaffold materials are preferable candidates for the differentiation of BFCNs from NPCs. CONCLUSIONS: These results suggest new opportunities for the application of 3D-GF scaffold as a neural scaffold for cholinergic neurons therapies based on NPCs.

2.
Sci Rep ; 10(1): 12607, 2020 07 28.
Artigo em Inglês | MEDLINE | ID: mdl-32724040

RESUMO

Using symbiotic farming methods [cover crops and chicken grazing (+ C)] in a winter fallow field, we found that the soil organic matter and total nitrogen of the + C treatment were 5.2% and 26.6% higher, respectively, than those of a treatment with cover crops and no chicken grazing (- C). The annual rice grain yield of the + C treatment was 3.8% higher than that of the - C treatment and 12.3% higher than that of the bare fallow field (CK), while the annual CH4 emissions of the + C treatment were 26.9% lower than those of the - C treatment and 10.6% lower than those of the CK treatment. The 100-year global warming potential of the + C treatment was 6.2% lower than that of the - C treatment. Therefore, the use of winter cover crops and chicken grazing in a winter fallow field was effective at reducing CH4 emissions and significantly improving soil nutrients and rice yield.

3.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 25(2): 460-3, 2008 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-18610642

RESUMO

In the end of last century, there was a leap in the technological quality of radiotherapy, which is incarnated in three new technologies: Stereotactic radiation surgery (SRS), three-dimensional conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy (IMRT). However, the achievement of these technologies has a close relationship with the precise orientation of tumour. Especially, in terms of body stereotactic precise radiation therapy, its body mechanical orientation system is the kernel to guarantee the accuracy of radiotherapy. This paper presents a novel mechanical orientation system for body precise radiotherapy. It is characterized by flexible adjustment, deft removal, easy disassembly and accurate orientation using apart structure to substitute old integer structure and adopting single segment Z shape orientation marker staff. The new mechanical orientation system guarantees the effect of tumour radiotherapy, which is worthy to be recommended for clinical use.


Assuntos
Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Planejamento da Radioterapia Assistida por Computador/instrumentação , Radioterapia de Intensidade Modulada/instrumentação , Tomografia Computadorizada por Raios X/métodos , Humanos , Imagens de Fantasmas , Radiografia Intervencionista , Radioterapia Conformacional/instrumentação , Técnicas Estereotáxicas
4.
Zhongguo Yi Liao Qi Xie Za Zhi ; 32(2): 102-4, 2008 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-18581873

RESUMO

This paper presents a novel x-ray dose testing water tank used for the stereotactic radiation therapy system, including its constitution, structure and the method of using it. The water tank has a simple structure of inner and outer sleeves which are connected through a drowned pump and a water pipe in order to control the water level of the tank. The water tank featuring autoregulation and easy use is worthy of clinical application and popularization.


Assuntos
Radiocirurgia/instrumentação , Planejamento da Radioterapia Assistida por Computador/instrumentação , Desenho de Equipamento , Radiocirurgia/métodos , Dosagem Radioterapêutica , Planejamento da Radioterapia Assistida por Computador/métodos
5.
Di Yi Jun Yi Da Xue Xue Bao ; 25(12): 1494-7, 2005 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-16354614

RESUMO

OBJECTIVE: To develop a new method for static intensity-modulated radiation therapy (IMRT) possible for implementation in smaller hospitals by incorporating accurate location equipments and treatment planning system in the available equipments for general radiotherapy. METHODS: Based on the techniques of conformal radiotherapy, a new split method for fabricating the three-dimensional physical compensator was developed to achieve IMRT. RESULTS: Experiment with the new method showed that the fabricated compensator could achieve good match between the high dosage shape in the target area and the dimensions of the tumor, and allowed adjustment of the dosage distribution according to the therapeutic requirement. CONCLUSION: This simple and feasible method allows cost-effect application of IMRT in smaller hospitals.


Assuntos
Planejamento da Radioterapia Assistida por Computador/métodos , Radioterapia Conformacional/instrumentação , Radioterapia Conformacional/métodos , Humanos , Dosagem Radioterapêutica
6.
Zhongguo Yi Liao Qi Xie Za Zhi ; 29(4): 250-1, 262, 2005 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-16268348

RESUMO

This paper introduces the constitution and fabrication of the new head and neck stereotactic conformal radiotherapy system. It remedies the shortages in the head and neck stereotactic conformal radiotherapy at present and it is deserved to be popularized in clinical applications.


Assuntos
Radiocirurgia/instrumentação , Radioterapia Conformacional/instrumentação , Desenho de Equipamento , Cabeça/diagnóstico por imagem , Cabeça/cirurgia , Neoplasias de Cabeça e Pescoço/diagnóstico por imagem , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Pescoço/diagnóstico por imagem , Pescoço/cirurgia , Radiografia
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