New insights into balancing wound healing and scarless skin repair.

Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar free wound repair has been greatly expanded. However, understanding the complex mechanisms of wound healing, in which various cells, cytokines and mechanical force interact, is critical to developing a treatment that can achieve scarless wound healing. Therefore, this paper reviews the types of wounds, the mechanism of scar formation in the healing process, and the current research progress on the dual consideration of wound healing and scar prevention, and some strategies for the treatment of scar free wound repair.

Energy Harvesting System Whose Potential Is Mapped with the Modified Fibonacci Function.

In this paper, we compare three energy harvesting systems in which we introduce additional bumpers whose mathematical model is mapped with a non-linear characteristic based on the hyperbolic sine Fibonacci function. For the analysis, we construct non-linear two-well, three-well and four-well systems with a cantilever beam and permanent magnets. In order to compare the effectiveness of the systems, we assume comparable distances between local minima of external wells and the maximum heights of potential barriers. Based on the derived dimensionless models of the systems, we perform simulations of non-linear dynamics in a wide spectrum of frequencies to search for chaotic and periodic motion zones of the systems. We present the issue of the occurrence of transient chaos in the analyzed systems. In the second part of this work, we determine and compare the effectiveness of the tested structures depending on the characteristics of the bumpers and an external excitation whose dynamics are described by the harmonic function, and find the best solutions from the point view of energy harvesting. The most effective impact of the use of bumpers can be observed when dealing with systems described by potential with deep external wells. In addition, the use of the Fibonacci hyperbolic sine is a simple and effective numerical tool for mapping non-linear properties of such motion limiters in energy harvesting systems.

Double-Versus Triple-Potential Well Energy Harvesters: Dynamics and Power Output.

The basic types of multi-stable energy harvesters are bistable energy harvesting systems (BEH) and tristable energy harvesting systems (TEH). The present investigations focus on the analysis of BEH and TEH systems, where the corresponding depth of the potential well and the width of their characteristics are the same. The efficiency of energy harvesting for TEH and BEH systems assuming similar potential parameters is provided. Providing such parameters allows for reliable formulation of conclusions about the efficiency in both types of systems. These energy harvesting systems are based on permanent magnets and a cantilever beam designed to obtain energy from vibrations. Starting from the bond graphs, we derived the nonlinear equations of motion. Then, we followed the bifurcations along the increasing frequency for both configurations. To identify the character of particular solutions, we estimated their corresponding phase portraits, Poincare sections, and Lyapunov exponents. The selected solutions are associated with their voltage output. The results in this numerical study clearly show that the bistable potential is more efficient for energy harvesting provided the corresponding excitation amplitude is large enough. However, the tristable potential could work better in the limits of low-level and low-frequency excitations.

Application of Hydrogels as Three-Dimensional Bioprinting Ink for Tissue Engineering.

The use of three-dimensional bioprinting technology combined with the principle of tissue engineering is important for the construction of tissue or organ regeneration microenvironments. As a three-dimensional bioprinting ink, hydrogels need to be highly printable and provide a stiff and cell-friendly microenvironment. At present, hydrogels are used as bioprinting inks in tissue engineering. However, there is still a lack of summary of the latest 3D printing technology and the properties of hydrogel materials. In this paper, the materials commonly used as hydrogel bioinks; the advanced technologies including inkjet bioprinting, extrusion bioprinting, laser-assisted bioprinting, stereolithography bioprinting, suspension bioprinting, and digital 3D bioprinting technologies; printing characterization including printability and fidelity; biological properties, and the application fields of bioprinting hydrogels in bone tissue engineering, skin tissue engineering, cardiovascular tissue engineering are reviewed, and the current problems and future directions are prospected.

Energy Harvesting in a System with a Two-Stage Flexible Cantilever Beam.

The subject of the research contained in this paper is a new design solution for an energy harvesting system resulting from the combination of a quasi-zero-stiffness energy harvester and a two-stage flexible cantilever beam. Numerical tests were divided into two main parts-analysis of the dynamics of the system due to periodic, quasiperiodic, and chaotic solutions and the efficiency of energy generation. The results of numerical simulations were limited to zero initial conditions as they are the natural position of the static equilibrium. The article compares the energy efficiency for the selected range of the dimensionless excitation frequency. For this purpose, three cases of piezoelectric mounting were analyzed-only on the first stage of the beam, on the second and both stages. The analysis has been carried out with the use of diagrams showing difference of the effective values of the voltage induced on the piezoelectric electrodes. The results indicate that for effective energy harvesting, it is advisable to attach piezoelectric energy transducers to each step of the beam despite possible asynchronous vibrations.

N-Annulated Perylene Bisimide-Based Double-Cable Polymers with Open-Circuit Voltage Approaching 1.20 V in Single-Component Organic Solar Cells.

In this work, we have introduced single/double-sided N-annulated perylene bisimide (PBI) with deep energy levels into double-cable polymers with poly[1-(5-(4,8-bis(4-chloro-5-(2-ethylhexyl)thiophen-2-yl)-6-methylbenzo[1,2-b:4,5-b']dithiophen-2-yl)thiophen-2-yl)-5,7-bis(2-ethylhexyl)-3-(5-methylthiophen-2-yl)-4H,8H-benzo[1,2-c:4,5-c']dithiophene-4,8-dione] (PBDB-T-Cl) as a donor backbone, marking as s-PPNR and as-PPNR, according to the molecular symmetry. Both double-cable polymers displayed a high open-circuit voltage approaching 1.20 V in light of high energy level discrepancy between electron-donating and electron-withdrawing parts, which is the highest open-circuit voltage among double-cable-based single-component organic solar cell (SCOSC) devices. Additionally, the asymmetric polymer displayed improved absorption spectra, thereby promoting crystallization and phase separation. Consequently, the as-PPNR-based SCOSCs achieved a power conversion efficiency of 5.05% along with a higher short-circuit current density and fill factor than their s-PPNR-based counterparts. In this work, we have successfully incorporated N-annulated PBI into double-cable polymers and revealed the important effects on structural symmetry and phase separation of double-cable polymers for higher SCOSC performance.

Enhancing the Performance of Small-Molecule Organic Solar Cells via Fused-Ring Design.

Organic solar cells (OSCs) as the promising green energy technology have drawn much attention in the last two decades. In comparison to polymer solar cells, small-molecule organic solar cells (SMOSCs) have the advantages of precise chemical structure and molecular weight, purification feasibility, batch reproducibility, etc. Despite of the recent advances in molecular design, the efficiencies of SMOSCs are still lagging behind those of polymer-based OSCs. In this work, a new small-molecule donor (SMD) with a fused-ring-connected bridge denoted F-MD has been designed and synthesized. When F-MD was applied into SMOSCs, the F-MD:N3 blends exhibited a power conversion efficiency (PCE) of over 13%, which is much higher than that of the linear π-bridged molecule L-MD based devices (8.12%). Further studies revealed that the fused-ring design promoted the planarity of the molecular conformation and facilitated charge transport in OSCs. More importantly, this strategy also lowered the crystallinity and self-aggregation of the films, and hence optimized the microstructure and phase separation in the corresponding blends. Thereby, the F-MD-based blends have been evidenced to have better exciton dissociation and reduced charge recombination in comparison with the L-MD counterparts, explaining the enhanced PCEs. Our work demonstrates that the fused-ring π-bridge strategy in small-molecule-donor design is an effective pathway to promote the efficiency of SMOSCs as well as enhance the diversity of SMD materials.

Parameter estimation for a damped real-valued sinusoid in noise.

In this paper, a three-point interpolation algorithm based on the discrete Fourier transform (DFT) is presented for a damped real-valued sinusoid, and the algorithm considers comprehensively the contribution of negative frequency to the parameter estimation (including that of the frequency and the damping factor). The proposed algorithm uses the DFT spectral bin with the maximum amplitude and two other arbitrary ones within the main lobe of the spectrum of the rectangular window to remove the negative-frequency interference completely. First, the effect of changed length of samples on the performance of the proposed algorithm is investigated, and the influence of the zero-padding technique and the selection of two arbitrary spectral bins on the ratio of the mean-square error (MSE) to the Crámer-Rao lower bound are also analyzed by simulations. Second, the MSEs of the estimated parameters are calculated to evaluate the performances of the proposed algorithm and state-of-the-art DFT-based algorithms in the literature. Third, the computational complexities of the proposed and comparative algorithms are analyzed. The results confirm the effectiveness of the proposed algorithm.

Compact Acoustic Rainbow Trapping in a Bioinspired Spiral Array of Graded Locally Resonant Metamaterials.

Acoustic rainbow trappers, based on frequency selective structures with graded geometries and/or properties, can filter mechanical waves spectrally and spatially to reduce noise and interference in receivers. These structures are especially useful as passive, always-on sensors in applications such as structural health monitoring. For devices that face space and weight constraints, such as microelectromechanical systems (MEMS) transducers and artificial cochleae, the rainbow trapping structures must be compact as well. To address this requirement, we investigated the frequency selection properties of a space-saving design consisting of Helmholtz resonators arranged at sub-wavelength intervals along a cochlear-inspired spiral tube. The height of the Helmholtz resonators was varied gradually, which induced bandgap formation at different frequencies along the length of the spiral tube. Numerical simulations and experimental measurements of acoustic wave propagation through the structure showed that frequencies in the range of 1⁻10 kHz were transmitted to different extents along the spiral tube. These rainbow trapping results were achieved with a footprint that was up to 70 times smaller than the previous structures operating at similar bandwidths, and the channels are 2.5 times of the previous structures operating at similar bandwidths.

A Novel Nonlinear Piezoelectric Energy Harvesting System Based on Linear-Element Coupling: Design, Modeling and Dynamic Analysis.

This paper presents a novel nonlinear piezoelectric energy harvesting system which consists of linear piezoelectric energy harvesters connected by linear springs. In principle, the presented nonlinear system can improve broadband energy harvesting efficiency where magnets are forbidden. The linear spring inevitably produces the nonlinear spring force on the connected harvesters, because of the geometrical relationship and the time-varying relative displacement between two adjacent harvesters. Therefore, the presented nonlinear system has strong nonlinear characteristics. A theoretical model of the presented nonlinear system is deduced, based on Euler-Bernoulli beam theory, Kirchhoff’s law, piezoelectric theory and the relevant geometrical relationship. The energy harvesting enhancement of the presented nonlinear system (when n = 2, 3) is numerically verified by comparing with its linear counterparts. In the case study, the output power area of the presented nonlinear system with two and three energy harvesters is 268.8% and 339.8% of their linear counterparts, respectively. In addition, the nonlinear dynamic response characteristics are analyzed via bifurcation diagrams, Poincare maps of the phase trajectory, and the spectrum of the output voltage.

Effect of Tulathromycin on Colonization Resistance, Antimicrobial Resistance, and Virulence of Human Gut Microbiota in Chemostats.

To evaluate microbiological safety of tulathromycin on human intestinal bacteria, tulathromycin (0, 0.1, 1, 10, and 100 µg/mL) was added into Chemostats. Before and after drug exposure, we monitored (1) population, SCFA products, antimicrobial resistance, and colonization resistance of gut microbiota, and (2) the antimicrobial resistance genes, transferability, virulent genes, pathogenicity of Enterococus faecalis. Results showed that low level of tulathromycin did not exhibit microbiological hazard on resistance selection and colonization resistance. However, high level of tulathromycin (10 and 100 µg/mL) may disturb colonization resistance of human gut microbiota and select antimicrobial resistant E. faecalis. Most of the selected resistant E. faecalis carried resistant gene of ermB, transferable element of Tn1545 and three virulence genes (esp, cylA, and ace). One of them (E. faecalis 143) was confirmed to have higher horizontal transfer risk and higher pathogenicity. The calculated no observable adverse effect concentration (NOAEC) and microbiological acceptable daily intake (mADI) in our study was 1 µg/mL and 14.66 µg/kg.bw/day, respectively.