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1.
Nature ; 618(7965): 531-536, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-37316722

RESUMO

Plate tectonics is a fundamental factor in the sustained habitability of Earth, but its time of onset is unknown, with ages ranging from the Hadaean to Proterozoic eons1-3. Plate motion is a key diagnostic to distinguish between plate and stagnant-lid tectonics, but palaeomagnetic tests have been thwarted because the planet's oldest extant rocks have been metamorphosed and/or deformed4. Herein, we report palaeointensity data from Hadaean-age to Mesoarchaean-age single detrital zircons bearing primary magnetite inclusions from the Barberton Greenstone Belt of South Africa5. These reveal a pattern of palaeointensities from the Eoarchaean (about 3.9 billion years ago (Ga)) to Mesoarchaean (about 3.3 Ga) eras that is nearly identical to that defined by primary magnetizations from the Jack Hills (JH; Western Australia)6,7, further demonstrating the recording fidelity of select detrital zircons. Moreover, palaeofield values are nearly constant between about 3.9 Ga and about 3.4 Ga. This indicates unvarying latitudes, an observation distinct from plate tectonics of the past 600 million years (Myr) but predicted by stagnant-lid convection. If life originated by the Eoarchaean8, and persisted to the occurrence of stromatolites half a billion years later9, it did so when Earth was in a stagnant-lid regime, without plate-tectonics-driven geochemical cycling.

2.
Nat Commun ; 13(1): 4161, 2022 07 19.
Artigo em Inglês | MEDLINE | ID: mdl-35853855

RESUMO

Paleomagnetism can elucidate the origin of inner core structure by establishing when crystallization started. The salient signal is an ultralow field strength, associated with waning thermal energy to power the geodynamo from core-mantle heat flux, followed by a sharp intensity increase as new thermal and compositional sources of buoyancy become available once inner core nucleation (ICN) commences. Ultralow fields have been reported from Ediacaran (~565 Ma) rocks, but the transition to stronger strengths has been unclear. Herein, we present single crystal paleointensity results from early Cambrian (~532 Ma) anorthosites of Oklahoma. These yield a time-averaged dipole moment 5 times greater than that of the Ediacaran Period. This rapid renewal of the field, together with data defining ultralow strengths, constrains ICN to ~550 Ma. Thermal modeling using this onset age suggests the inner core had grown to 50% of its current radius, where seismic anisotropy changes, by ~450 Ma. We propose the seismic anisotropy of the outermost inner core reflects development of a global spherical harmonic degree-2 deep mantle structure at this time that has persisted to the present day. The imprint of an older degree-1 pattern is preserved in the innermost inner core.


Assuntos
Fósseis , Tempo
3.
Clin Chim Acta ; 523: 513-518, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34742678

RESUMO

BACKGROUND: Sepsis remains associated with a high mortality rate despite recent advances in treatment. Traditional biomarkers are inadequate for stratification of patients by sepsis severity. We examined use of the baseline concentration of fibroblast growth factor 19 (FGF19) in predicting 28-day mortality from sepsis. METHODS: A total of 220 consecutive adult patients with sepsis who were admitted to our intensive care unit (ICU) during 2020 were prospectively recruited. Patients were categorized as survivors or non-survivors according to status at 28 days. Baseline concentrations of FGF19 and other parameters were measured. Receiver operating characteristic (ROC) analysis was used to determine the sensitivity, specificity, predictive value, and optimal cutoff of FGF19 in prediction of survival. Prognostic factors were identified using Cox regression analysis. RESULTS: The serum FGF19 concentration was much higher in non-survivors than in survivors (355.0 pg/ml [range: 37.2, 2315.6] vs. 127.3 pg/ml [5.7, 944.1]; P < 0.05]. ROC analysis indicated an FGF19 concentration of 180 pg/ml was the optimal cutoff value. Multivariable Cox regression analysis showed that FGF19 concentration and the change in sequential organ failure assessment (ΔSOFA) score at baseline were independently and significantly associated with 28-day mortality. ROC analysis indicated that FGF19 had a better predictive value than PCT or CRP. Although ΔSOFA had a better predictive value than FGF19, ΔSOFA and FGF19 together had a significantly better predictive value than ΔSOFA alone. CONCLUSION: Sepsis patients with high serum concentrations of FGF19 at ICU admission were associated with an increased risk of 28-day mortality in our ICU.


Assuntos
Fatores de Crescimento de Fibroblastos/sangue , Sepse , Adulto , Biomarcadores/sangue , Humanos , Unidades de Terapia Intensiva , Prognóstico , Curva ROC , Estudos Retrospectivos , Sepse/diagnóstico , Sepse/mortalidade
4.
Sci Adv ; 7(32)2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34348904

RESUMO

Determining the presence or absence of a past long-lived lunar magnetic field is crucial for understanding how the Moon's interior and surface evolved. Here, we show that Apollo impact glass associated with a young 2 million-year-old crater records a strong Earth-like magnetization, providing evidence that impacts can impart intense signals to samples recovered from the Moon and other planetary bodies. Moreover, we show that silicate crystals bearing magnetic inclusions from Apollo samples formed at ∼3.9, 3.6, 3.3, and 3.2 billion years ago are capable of recording strong core dynamo-like fields but do not. Together, these data indicate that the Moon did not have a long-lived core dynamo. As a result, the Moon was not sheltered by a sustained paleomagnetosphere, and the lunar regolith should hold buried 3He, water, and other volatile resources acquired from solar winds and Earth's magnetosphere over some 4 billion years.

5.
J Inflamm Res ; 14: 3837-3848, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34408466

RESUMO

BACKGROUND: Sepsis is the leading cause of death in critically ill patients, and the prevention of which requires precise outcome prediction and early intervention. We evaluated the prognostic prediction value of serum thioredoxin-1 (Trx-1) as an anti-inflammatory factor in patients with sepsis. METHODS: As a prospective study, patients with sepsis admitted to the intensive care unit (ICU) of our hospital during 2020 were recruited. Medical history collection, sequential organ failure assessment (ΔSOFA), and laboratory tests were performed within 24 h of admission. Serum levels of Trx-1 and other inflammatory biomarkers were detected with samples dynamically collected before, during, and after septic shock. Patients were categorized as survivors and non-survivors according to survival status on day 28. Correlation between Trx-1 and other sepsis-associated parameters as well as the correlation of Trx-1 and other sepsis-associated parameters with 28-day mortality were evaluated. Prognostic factors were identified by Cox regression analyses. RESULTS: A total of 187 patients were recruited. Serum Trx-1 level was positively correlated with inflammatory factors (interleukin-6, C-reactive protein, procalcitonin) and index of sepsis severity (ΔSOFA score, partial pressure of oxygen/fraction of inspired oxygen), all of which were significantly higher in non-survivors than survivors. While Trx-1 level at different timepoints and its evolution over time significantly differed between survivors and non-survivors, the initial Trx-1 level outperformed the other parameters in predicting 28-day survival. With 38.27 ng/mL as the cutoff value, serum Trx-1 predicted 28-day survival with optimal sensitivity and specificity. CONCLUSION: Early increases in serum levels of Trx-1 can predict 28-day mortality in sepsis patients in the ICU.

6.
Respir Res ; 22(1): 182, 2021 Jun 22.
Artigo em Inglês | MEDLINE | ID: mdl-34154595

RESUMO

BACKGROUND: Sepsis may be accompanied by acute respiratory distress syndrome (ARDS) in patients admitted to intensive care units (ICUs). It is essential to identify prognostic biomarkers in patients with sepsis and ARDS. OBJECTIVE: Determine whether changes in the level of serum fibroblast growth factor 21 (FGF21) can predict the 28-day mortality of ICU patients with sepsis and ARDS. METHODS: Consecutive sepsis patients were divided into two groups (Sepsis + ARDS and Sepsis-only), and the Sepsis + ARDS group was further classified as survivors or non-survivors. Demographic data and comorbidities were recorded. The Sequential Organ Failure Assessment (SOFA) score and serum levels of cytokines and other biomarkers were recorded 3 times after admission. Multiple Cox proportional hazards regression was used to identify risk factors associated with 28-day mortality in the Sepsis + ARDS group. Multivariate receiver operating characteristic curve analysis was used to assess the different predictive value of FGF21 and SOFA. RESULTS: The Sepsis + ARDS group had a greater baseline SOFA score and serum levels of cytokines and other biomarkers than the Sepsis-only group; the serum level of FGF21 was almost twofold greater in the Sepsis + ARDS group (P < 0.05). Non-survivors in the Sepsis + ARDS group had an almost fourfold greater level of FGF21 than survivors in this group (P < 0.05). The serum level of FGF21 persistently increased from the baseline to the peak of shock and death in the non-survivors, but persistently decreased in survivors (P < 0.05). Changes in the serum FGF21 level between different time points were independent risk factors for mortality. No statistical difference was observed between the AUC of FGF21 and SOFA at baseline.  CONCLUSION: A large increase of serum FGF21 level from baseline is associated with 28-day mortality in ICU patients with sepsis and ARDS.


Assuntos
Estado Terminal/mortalidade , Fatores de Crescimento de Fibroblastos/sangue , Unidades de Terapia Intensiva/estatística & dados numéricos , Síndrome do Desconforto Respiratório/mortalidade , Sepse/mortalidade , Idoso , Biomarcadores/sangue , Feminino , Seguimentos , Mortalidade Hospitalar/tendências , Humanos , Masculino , Prognóstico , Estudos Prospectivos , Curva ROC , Síndrome do Desconforto Respiratório/sangue , Fatores de Risco , Sepse/sangue , Taxa de Sobrevida/tendências
7.
Clin Chim Acta ; 494: 31-37, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30853459

RESUMO

BACKGROUND: We examined the correlation between thyroid hormone (TH) concentrations and the serum fibroblast growth factor 21 (FGF21) concentration in septic patients and to assess the collaborative value of these factors in predicting 28-day mortality in septic patients. METHODS: A total of 120 consecutive patients with sepsis were divided into two groups according to their survival or death within 28 days after initial diagnosis of sepsis. RESULTS: Patients in the non-survivor group had significantly higher serum FGF21 concentrations but lower total and free triiodothyronine (T3) and tetraiodothyronine (T4) concentrations than those in the survivor group. Thyroid hormone concentrations, including T3, free T3, T4 and free T4, were significantly negatively correlated with the ∆SOFA and APACHE II scores as well as the serum FGF21, IL-6, tumor necrosis factor-α, IL-10, procalcitonin, and C-reactive protein concentrations. Logistic regression analysis showed that the ∆SOFA score, serum FGF21 concentration, and free T3 concentration were significant predictors of 28-day mortality. The model with variables of ∆SOFA score and serum FGF21 and free T3 concentrations had the greatest area under the curve of 0.969. CONCLUSION: The addition of free T3 and serum FGF21 to ∆SOFA score provided a significantly improved ability to predict 28-day mortality in septic patients.


Assuntos
Complexo CD3/sangue , Fatores de Crescimento de Fibroblastos/sangue , Sepse/sangue , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Curva ROC , Sepse/diagnóstico
8.
Int J Mol Sci ; 21(1)2019 Dec 30.
Artigo em Inglês | MEDLINE | ID: mdl-31905846

RESUMO

Floral color polymorphism can provide great insight into species evolution from a genetic and ecological standpoint. Color variations between species are often mediated by pollinators and are fixed characteristics, indicating their relevance to adaptive evolution, especially between plants within a single population or between similar species. The orchid genus Pleione has a wide variety of flower colors, from violet, rose-purple, pink, to white, but their color formation and its evolutionary mechanism are unclear. Here, we selected the P. limprichtii population in Huanglong, Sichuan Province, China, which displayed three color variations: Rose-purple, pink, and white, providing ideal material for exploring color variations with regard to species evolution. We investigated the distribution pattern of the different color morphs. The ratio of rose-purple:pink:white-flowered individuals was close to 6:3:1. We inferred that the distribution pattern may serve as a reproductive strategy to maintain the population size. Metabolome analysis was used to reveal that cyanindin derivatives and delphidin are the main color pigments involved. RNA sequencing was used to characterize anthocyanin biosynthetic pathway-related genes and reveal different color formation pathways and transcription factors in order to identify differentially-expressed genes and explore their relationship with color formation. In addition, qRT-PCR was used to validate the expression patterns of some of the genes. The results show that PlFLS serves as a crucial gene that contributes to white color formation and that PlANS and PlUFGT are related to the accumulation of anthocyanin which is responsible for color intensity, especially in pigmented flowers. Phylogenetic and co-expression analyses also identified a R2R3-MYB gene PlMYB10, which is predicted to combine with PlbHLH20 or PlbHLH26 along with PlWD40-1 to form an MBW protein complex (MYB, bHLH, and WDR) that regulates PlFLS expression and may serve as a repressor of anthocyanin accumulation-controlled color variations. Our results not only explain the molecular mechanism of color variation in P. limprichtii, but also contribute to the exploration of a flower color evolutionary model in Pleione, as well as other flowering plants.


Assuntos
Flores/genética , Flores/metabolismo , Regulação da Expressão Gênica de Plantas , Orchidaceae/genética , Orchidaceae/metabolismo , Polimorfismo Genético , Transcriptoma , Antocianinas/metabolismo , Vias Biossintéticas/genética , China , Cor , Proteínas de Ligação a DNA , Metaboloma , Orchidaceae/classificação , Filogenia , Pigmentação/genética , Proteínas de Plantas/metabolismo , Análise de Sequência de RNA
9.
Cytokine ; 111: 428-433, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-29861384

RESUMO

BACKGROUND: Potential prognostic biomarkers for patients with sepsis have yet to be identified. The present study evaluated the prognostic value of fibroblast growth factor 21 (FGF21) levels in patients with sepsis. METHODS: A total of 120 consecutive Chinese patients with sepsis were prospectively included, and serum levels of FGF21 and biomarkers such as interleukin (IL)-6, tumor necrosis factor alpha (TNF-α), IL-10, procalcitonin (PCT), C-reactive protein (CRP), and lactate (LAC) were measured within 24 h after intensive care unit admission. The demographic and clinical characteristics including underlying diseases, Sequential Organ Failure Assessment (△SOFA), and acute physiology and chronic health evaluation II (APACHE II) scores were recorded. Patients were categorized into survival and non-survival groups according to the 28-day mortality. Correlations between FGF21, serum indicators, severity score and 28-day mortality were analyzed, and Cox regression analysis was performed to identify prognostic factors. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off of FGF21 for survival prediction. RESULTS: Non-survivors had significantly higher levels of FGF21, IL-6, TNF-α, IL-10, PCT, CRP, and LAC as well as higher SOFA and APACHE II scores compared with the survivors. FGF21 levels were positively correlated with age, waist circumference, levels of IL-6, IL-10, TNF- α, PCT, CRP, and LAC, △SOFA and APACHE II scores. ROC curves showed that FGF21 had a high sensitivity of 81.3% and specificity of 89.8% for predicting 28-day mortality. Patients with a FGF21 levels <3200 pg/ml had a significantly better survival rate than those with levels >3200 pg/ml, and thus, FGF21 was an independent prognostic factor for survival. CONCLUSION: FGF21 could serve as a new prognostic biomarker for sepsis survival.


Assuntos
Biomarcadores/sangue , Fatores de Crescimento de Fibroblastos/sangue , Sepse/sangue , Sepse/mortalidade , Idoso , Proteína C-Reativa/metabolismo , Feminino , Humanos , Unidades de Terapia Intensiva , Interleucina-10/sangue , Interleucina-6/sangue , Ácido Láctico/sangue , Masculino , Pessoa de Meia-Idade , Pró-Calcitonina/sangue , Prognóstico , Estudos Prospectivos , Curva ROC , Sensibilidade e Especificidade , Sepse/metabolismo , Fator de Necrose Tumoral alfa/sangue
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