Does higher energy efficiency growth homogeneously affect carbon emission growth rate across developing Sub-Saharan African nations? The importance of utilizing clean energy.

Establishing a sustainable environment and acquiring a carbon-neutral status require Sub-Saharan African nations to reduce their year-on-year growth rates of carbon emission levels. Thus, this study considers a sample of 38 countries from this region and selects the time period from 2000 to 2020 for analyzing the annual carbon emission growth rate influencing impacts of energy efficiency, clean energy, institutional quality, international trade, and net receipts of foreign direct investment. Overall, for the full sample of Sub-Saharan African nations, the results verify that the enhancing the growth rate of energy efficiency improvement reduces both total and per capita annual carbon emission growth rates. Besides, the results endorse that enhancing renewable energy shares of the final energy consumption profiles and promoting good governance-led betterment of institutional quality also plunge emission growth rates in the long run. More importantly, energy efficiency improvement, renewable energy consumption, and better quality institutions are observed to jointly exert carbon emission growth rate-impeding effects, as well. By contrast, more openness to international trade is not seen to influence the carbon emission growth rates of the Sub-Saharan African nations of concern. Lastly, a greater share of net foreign direct investment receipts in the national output level is evidenced to boost annual carbon emission growth rates across this region; consequently, the pollution haven hypothesis is verified. Furthermore, these above-mentioned findings are found to be heterogeneous across groups of low-income and middle-income Sub-Saharan African nations. Accordingly, in line with the findings, a couple of policies are recommended to the governments of the Sub-Saharan African countries in order to guide them in designing effective environmental sustainability policies that are relevant for tackling climate change-related atrocities in the future.

Review of PINK1-Parkin-mediated mitochondrial autophagy in Alzheimer's disease.

Mitochondrial autophagy plays an important role in maintaining the complexity of mitochondrial functions and removing damaged mitochondria, of which the PINK1-Parkin signal pathway is one of the most classical pathways. Thus, a comprehensive and in-depth interpretation of the PINK1-Parkin signal pathway might deepen our understanding on the impacts of mitochondrial autophagy. Alzheimer's disease (AD) is a classical example of neurodegenerative disease. Research on the pathogenesis and treatments of AD has been a focus of scientific research because of its complexity and the limitations of current drug therapies. It was reported that the pathogenesis of AD might be related to mitochondrial autophagy due to excessive deposition of Aß protein and aggravation of the phosphorylation of Tau protein. Two key proteins in the PINK1-Parkin signaling pathway, PINK1 and Parkin, have important roles in the folding and accumulation of Aß protein and the phosphorylation of Tau protein. In addition, the intermediate signal molecules in the PINK1-Parkin signal pathway also have certain effects on AD. In this paper, we first described the role of PINK1-Parkin signal pathway on mitochondrial autophagy, then discussed and analyzed the effect of the PINK1-Parkin signal pathway in AD and other metabolic diseases. Our aim was to provide a theoretical direction to further elucidate the pathogenesis of AD and highlight the key molecules related to AD that could be important targets used for AD drug development.

Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer's Disease: A Systematic Review.

Alzheimer's disease (AD) is a degenerative disease of the central nervous system. The pathogenesis of AD has been explained using cholinergic, ß-amyloid toxicity, tau protein hyperphosphorylation, and oxidative stress theories. However, an effective treatment method has not been developed. In recent years, with the discovery of the brain-gut axis (BGA) and breakthroughs made in Parkinson's disease, depression, autism, and other diseases, BGA has become a hotspot in AD research. Several studies have shown that gut microbiota can affect the brain and behavior of patients with AD, especially their cognitive function. Animal models, fecal microbiota transplantation, and probiotic intervention also provide evidence regarding the correlation between gut microbiota and AD. This article discusses the relationship and related mechanisms between gut microbiota and AD based on BGA to provide possible strategies for preventing or alleviating AD symptoms by regulating gut microbiota.