1.
Org Lett
; 21(11): 4111-4115, 2019 06 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31124683
RESUMO
A protocol for highly enantioselective hydrogenation of racemic α-arylamino lactones with catalysis by site-specifically modified chiral spiro iridium complexes has been developed. With the optimized catalyst, racemic α-arylamino-γ-lactones and α-arylamino-δ-lactones could be hydrogenated to the corresponding chiral 2-amino diols with good to excellent enantioselectivities.