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Artigo
em Inglês
| MEDLINE
| ID: mdl-30628963
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; 129(14): 1759-60, 2016 Jul 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27411468
3.
J Org Chem
; 70(13): 5347-9, 2005 Jun 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15960548
RESUMO
PEG-400 [poly(ethylene glycol-400)] was found as an effective medium for the PdCl(2)(MeCN)(2)-catalyzed hydroalkylation cyclization of alkenyl beta-keto esters and amides. In PEG-400, no additives such as Me(3)SiCl and Ln(OTf)(3) were required for the complete conversion of alkenyl beta-keto esters. The results also showed that CuCl(2) could promote the reaction. In the presence of PdCl(2)(MeCN)(2), CuCl(2), and PEG-400, various alkenyl beta-keto esters and amides underwent a selective cyclization reaction to give good to excellent yields of the desired six-membered-ring carbocycles. Furthermore, the PdCl(2)(MeCN)(2)/CuCl(2)/PEG-400 system could be recycled and reused five times without any loss of catalytic activity.