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Zhonghua Nan Ke Xue ; 19(6): 539-41, 2013 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-23862234

RESUMO

OBJECTIVE: To evaluate the efficacy of daily low-dose tadalafil in the treatment of erectile dysfunction (ED) following pelvic fracture-induced urethral injury (PFUI). METHODS: Based on the length of time between pelvic fracture and the patients' clinic visit, we divided 42 PFUI-caused ED patients into groups A (< 1 month), B (6-24 months) and C (> 24 months). We treated them with tadalafil at 5 mg daily for 12 weeks consecutively, followed by evaluation of the therapeutic effect using IIEF-5 questionnaire and Sexual Encounter Profile (SEP) diaries. RESULTS: Thirty-four patients (83.3%) completed the investigation and all responded well to tadalafil medication. Group A showed significant differences from B and C in the increase of IIEF-5 scores and the positive rate of SEP. CONCLUSION: Daily low-dose tadalafil helps penile rehabilitation in ED patients following PFUI, and the earlier the medication is initiated, the better the effect will be.


Assuntos
Carbolinas/administração & dosagem , Disfunção Erétil/tratamento farmacológico , Disfunção Erétil/etiologia , Uretra/lesões , Adulto , Carbolinas/uso terapêutico , Relação Dose-Resposta a Droga , Fraturas Ósseas/complicações , Humanos , Masculino , Pelve/lesões , Tadalafila , Resultado do Tratamento
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