Dissociation of drug and negative emotional cue induced attentional bias in individuals with methamphetamine-use disorder.

BACKGROUND AND OBJECTIVES: Although both drugs and negative emotions can trigger drug craving or relapse in individuals with methamphetamine-use disorder (MUD), it remains unclear whether individuals with MUD have attentional biases toward both drug and negative emotional cues and whether this bias involves attention orientation or difficulty in attention disengagement. This study aimed to measure different components of attentional bias toward drug-related and negative emotional cues in individuals with MUD. METHODS: Two dot-probe tasks were used to investigate attentional bias toward drug (drug task) and negative emotional cues (emotion task) in individuals with MUD. Forty-three males with MUD (average age of 43.44 ± 11.91 years, average drug-use duration of 11.35 ± 8.39 years) participated in the study voluntarily. RESULTS: There was a significant interaction between the task type and location (p = .01). Specifically, for drug cues, participants showed significant difficulty in attention disengagement toward drug cues (p = .01); however, no attention orientation (p = .46). For negative emotional cues, neither significant attention orientation (p = .07) nor significant difficulty in attention disengagement (p = .50) was found. CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: Attentional bias in individuals with MUD was highly selective for drug cues; thus, difficulty in attention disengagement from drug cues can be considered a potential mediating mechanism for attentional bias modification interventions for individuals with MUD. This study served to generate hypotheses or suggest future experiments on interventions for individuals with MUD.

A gated temporal-separable attention network for EEG-based depression recognition.

Depression, a common mental illness worldwide, needs to be diagnosed and cured at an early stage. To assist clinical diagnosis, an EEG-based deep learning frame, which is named the gated temporal-separable attention network (GTSAN), is proposed in this paper for depression recognition. GTSAN model extracts discriminative information from EEG recordings in two ways. On the one hand, the gated recurrent unit (GRU) is used in the GTSAN model to capture the EEG historical information to form the features. On the other hand, the model digs the multilevel information by using an improved version of temporal convolutional network (TCN), called temporal-separable convolution network (TSCN), which applies causal convolution and dilated convolution to extract features from fine to coarse scales. The TSCN and GRU features can be produced in parallel. Finally, the new model introduces the attention mechanism to give different weights to these features, allowing them to be used to identify depression more effectively. Experiments on two depression datasets have demonstrated that the proposed model can mine potential depression patterns in data and obtain high recognition accuracies. The proposed model provides the possibility of using an EEG-based system to assist for diagnosing depression.

Neurocognitive correlates of psychological resilience: Event-related potential studies.

BACKGROUND: There is a growing interest in exploring the neurocognitive mechanisms that may underlie psychological resilience. However, how the bottom-up automatic information processing relates to trait resilience has received less attention. We aimed to explore the relationship between trait resilience and trait-like automatic information processing in healthy adults. METHODS: Eighty-four healthy adults were recruited to explore whether and how resilience was related to sensory sensitivity by event-related potentials (ERPs). Resilience was measured by Connor-Davidson Resilience Scale (CD-RISC). Sensory sensitivity, more specifically, sensitivity of automatic mismatch detection was measured by two ERPs components, i.e., the mismatch negativity (MMN) with a passive auditory oddball paradigm and the error-related negativity (ERN) with an auditory Go/NoGo task. Using the multiple linear regression analyses, the relationship between self-reported resilience and the sensitivity of automatic mismatch detection (MMN/ERN amplitude/latency) was explored. RESULTS: The results showed that psychological resilience was positively correlated with both MMN and ERN latencies, i.e., higher resilience scores were associated with delayed MMN and ERN latencies. However, resilience was not significantly correlated with MMN and ERN amplitudes. CONCLUSIONS: Our results suggested that relatively higher resilience might link with less sensory sensitivity as reflected by slower automatic detection to mismatch information in the environment.

Development and Validation of Chinese Parental Involvement and Support Scale for Preschool Children.

The present study developed the Chinese Parental Involvement and Support Scale for Preschool Children (CPISSPC) to measure parental involvement and support for preschool children. In Study 1, we conducted a literature review, open-ended interviews, a theoretical analysis, and expert interviews to create an item bank (58 items). In Study 2, 447 parents completed the item bank. Following item and Exploratory Factor Analysis, 30 items were retained. In Study 3, five new items were added to the 30-item version of the CPISSPC. A separate sample of 471 parents completed the 35-item version of the CPISSPC. After Confirmatory Factor Analysis, a final 18-item version of the CPISSPC was created with four factors: psychological support, educational support, play support, and life support. Construct validity and internal reliability (Cronbach's α = 0.88) were satisfactory. Study 4 evaluated concurrent validity (n = 318). CPISSPC scores significantly and positively correlated with perceived social support, marital gratification, and children's self-efficacy. CPISSPC scores significantly and negatively correlated with parents' levels of burnout and loneliness. The CPISSPC exhibits good psychometric properties and can be used as a tool to measure parental involvement and support for preschool children.

Developmental Trajectory of Depressive Symptoms in Chinese College Students: Latent Classes and Gender Effect.

Depressive symptoms are prevalent in Chinese college students, but little is known about the heterogeneity in the developmental trajectory of depressive symptoms in China. This study examined heterogeneity in the development of depressive symptoms and examined the effect of gender on the developmental trajectories over a 14-month period among Chinese college students (N = 1163, mean age 20.18, 80.31% female). Three different trajectories, moderate-increasing, high-stable and low-stable, captured the heterogeneity in the development of depressive symptoms. Gender showed significant influence on class membership. Relative to the moderate-increasing class, males emerged as significantly more likely than females to be found in the low-stable class (odds ratio (OR) = 2.73, 95% CI = (1.21, 6.13), p = 0.015) and the high-stable class (OR = 5.10, 95% CI = (1.12, 23.18), p = 0.035). The results provide additional evidence for the conclusion that the trajectories of depressive symptoms are heterogeneous with Chinese samples. Moreover, cultural difference should be paid more attention to when examining the effect of gender and other predictors of the trajectories of depressive symptoms.

How anxiety predicts interpersonal curiosity during the COVID-19 pandemic: The mediation effect of interpersonal distancing and autistic tendency.

With the worldwide implementation of quarantine regulations to suppress the spread of the COVID-19, anxiety, interpersonal distancing and autistic tendency may decrease individuals' desire to seek interpersonal information and thus might have negative effects on their interpersonal curiosity. Through behavioral paradigms and scales, two studies were conducted (Study 1: n = 570; Study 2: n = 501). We explored the predictive effect of anxiety on interpersonal curiosity in situations when mandatory isolation measures have led to dramatic changes in interpersonal distancing and autistic tendency. We found that interpersonal distancing and autistic tendency negatively predicted interpersonal curiosity, and these predictive effects suppressed the positive prediction of state anxiety to interpersonal curiosity. Our research provides insights into the relationships among anxiety, curiosity, interpersonal distancing, and autistic tendency during the COVID-19 pandemic.

Passive and active suicidal ideation among left-behind children in rural China: An evaluation of intrapersonal and interpersonal vulnerability and resilience.

OBJECTIVE: Although theoretical conceptualizations of suicide hold that passive and active suicidal ideation are etiologically distinct, existing research observing this distinction is modest, with most prior studies focusing exclusively on active ideation. Understanding processes associated with passive ideation is clinically important insofar as passive ideation may precede active ideation, and thus serve as an earlier intervention target prior to potential onset of suicidal behavior. We aimed to evaluate intrapersonal and interpersonal vulnerability and resilience factors for passive ideation and differentiating passive from active ideation. METHOD: Left-behind adolescents in rural China (n = 371) were assessed for passive and active ideation, depressive symptoms, rumination, grit, peer support, and peer victimization. RESULTS: Overall, 15.9% of the sample endorsed passive ideation without active ideation, and 17.8% endorsed active ideation. In multivariate analyses, rumination and grit differentiated left-behind children with passive ideation from those with no ideation. Depressive symptom severity predicted active ideation among adolescents with passive ideation. CONCLUSIONS: The current findings suggest that rumination and grit may characterize passive ideation. Although passive and active ideation may differ modestly in vulnerability and resilience factors, depressive symptoms may be important to monitor among those with passive ideation and have not yet experience active ideation.

The Validation of Chinese Version of the Victimization Subscale of the Revised Peer Experiences Questionnaire.

In China, researchers have translated and validated several scales to measure victimization behavior. The aim of the present study was to validate the Chinese version of the victimization subscale of the Revised Peer Experiences Questionnaire (RPEQ) among primary school students. Primary school students aged between 8 and 13 years old (n = 1048) were asked to complete the Chinese version of the victimization subscale of the RPEQ and related scales. We examined internal consistency and the factor structure using confirmatory factor analysis (CFA). Depression, peer relationship, and sleep scales were used to measure construct validity. The CFA results suggested that the four-factor model had a good model fit. The results indicated that internal reliability was good (Cronbach's α = 0.83). Construct validity was mostly supported by scores on the Chinese version of the victimization subscale of the RPEQ that strongly and positively correlated with depression and negatively correlated with peer relationship and sleep quality. The present study indicated that the Chinese version of the victimization subscale of the RPEQ has adequate reliability and validity for measuring bullying problems among Chinese primary school students.

Self-awareness buffers the consequences of negative feedback: Evidence from an ERP study.

Previous studies have found that self-awareness can help people to recruit more cognitive resources, while people with more cognitive resources can better buffer the detrimental effects of negative events. However, it is not clear whether self-awareness can directly buffer the consequences of negative feedback (i.e., reducing neural sensitivity to negative feedback). To explore this issue, we used a scrambled sentence task (SST) to manipulate participants' self-awareness (self vs. other) and investigated whether outcome evaluations in a gambling task are modulated by the self-awareness priming. Event-related brain potentials (ERPs) were recorded while 27 normal adults performed a gambling task. The ERP analysis focused on the feedback-related negativity (FRN), reward positivity (RewP) and P300 component. We found that the self-awareness priming resulted in a smaller FRN response to the losses compared with the other-awareness priming. There was no significant difference in the RewP response to wins between the self-awareness condition and the other-awareness condition. We also found that the self-awareness condition evoked larger P300 amplitude than the other-awareness condition. The present findings suggest that self-awareness can help people to cope with negative feedback in the early semiautomatic outcome evaluation stage (i.e., reducing neural sensitivity to negative feedback) and enhance top-down evaluation to both positive and negative feedback in the late and deliberate stage, providing direct evidence of the adaptive function of self-awareness on outcome experience.

Effect of intranasal oxytocin administration on self-other distinction: Modulations by psychological distance and gender.

Preliminary evidence indicates that intranasal oxytocin (OT) administration modulates one's ability to distinguish oneself from others (i.e., self-other distinction). However, previous findings on this topic are contradictory. The current study addressed this issue by (i) using a novel perceptual matching task examining self-other distinction compared to both close and distant others, and (ii) tentatively exploring potential modulations by gender. In a double-blind, placebo-controlled, randomized OT administration study, 100 participants (50 males and 50 females) were randomized to receive intranasal spray of 24 IU OT or placebo (PL). Afterwards, participants completed a geometry perceptual matching task in which different shapes were paired to the self, a friend, or a stranger. Participants were then asked to judge whether each pair of shapes and labels was correctly matched. The results revealed that compared to PL administration, OT facilitated distinction between the self and a friend in males but not in females. These findings provide insights for debates on the role of OT in self-other distinction by revealing modulations by psychological distance and gender, which have implications for the potential clinical applications of OT.

The influence of self-construals on the ERP response to the rewards for self and friend.

Temporary self-construal (independent vs. interdependent) priming can modulate the neural response to the reward for an individual. Our previous event-related potential (ERP) studies have indicated that people experience the rewards for a friend less strongly than they experience the same amount rewards for themselves. However, an issue remaining unclear is whether the ERP responses to rewards for a friend vary according to the way in which the self is construed. In the present study, we manipulated participants' self-construal (independent vs. interdependent) and found that independent self-construal priming resulted in a greater feedback-related negativity (FRN) in response to outcome feedback for oneself than for a friend during a monetary gambling task. In contrast, interdependent self-construal priming resulted in a comparable FRN in response to outcome feedback for oneself and for a friend. The P3 amplitude was insensitive to the self-construal manipulation. Our findings suggest that interdependent priming may result in comparable motivation elicited by rewards for participants themselves and for their friends. This study provides novel evidence that the neural response to rewards for friend varies according to the way in which the self is construed.

Valence makes a stronger contribution than arousal to affective priming.

BACKGROUND: Recent data suggest that both word valence and arousal modulate subsequent cognitive processing. However, whether valence or arousal makes a stronger contribution to cognitive processing is less understood. METHODS: The present study performed three experiments that varied the valence (positive or negative) and arousal (high or low) of prime-target word pairs in a lexical decision-priming task. Affective priming was derived from pure valence (Experiment 1), pure arousal (Experiment 2), or a combination of valence and arousal (Experiment 3). RESULTS: By comparing three types of priming effects, we found an effect of valence on affective priming was obvious regardless of whether the relationship of the prime-target varied with valence, arousal, or the combination of valence and arousal. In contrast, an effect of arousal on affective priming only appeared in the condition that based on the arousal relationship of the prime-target pair. Moreover, the valence-driven priming effect, arousal-driven priming effect, and emotional-driven priming effect were modulated by valence type but not by arousal level of word stimuli. CONCLUSION: The present results revealed a pattern of valence and arousal in semantic networks, indicating that the valence information of emotional words tends to be more stable than arousal information within the semantic system, at least in the present lexical decision-priming task.

Effect of experience information on emotional word processing in alexithymia.

BACKGROUND: Alexithymia is an at-risk personality trait that is associated with deficits in processing emotional words. However, little is known about whether the effect of emotional valence (neutral, positive, and negative) on word processing in alexithymia is related to individual differences in sensorimotor or affective information processing that is associated with alexithymia and experience information (sensorimotor vs. affective) that is denoted by words. METHODS: The present study performed two experiments to explore this issue. In Experiment 1, we orthogonally manipulated experience information that was denoted by neutral words. In Experiment 2, we orthogonally manipulated experience information that was denoted by valenced words (i.e., positive and negative). We asked two groups of healthy individuals with high scores (high alexithymic [HA] group) or low scores (low alexithymic [LA] group) on the 20-item Toronto-Alexithymia-Scale to complete a lexical decision task. RESULTS: The results showed that emotional word processing in the HA group was modulated by a joint effect of valence and experience information, indicating that selective deficits in the processing of neutral and negative words were loaded more by sensorimotor information and that selective deficits in the processing of positive words were loaded more by affective experience compared with the LA group. CONCLUSION: These findings shed a new light on emotional word processing in alexithymia and suggest that alexithymic deficits in the processing of emotional words should not be considered as being simply related to general or specific valence but rather related to experience information that is denoted by the meanings of words.

The effect of emotional and self-referential contexts on ERP responses towards surprised faces.

The perception of surprised faces is demonstrably modulated by emotional context. However, the influence of self-relevance and its interaction with emotional context have not been explored. The present study investigated the effects of contextual valence and self-reference on the perception of surprised faces. Our results revealed that faces in a negative context elicited a larger N170 than those in a neutral context. The EPN was affected by the interaction between contextual valence and self-reference, with larger amplitudes for faces in self-related positive contexts and sender-related negative contexts. Additionally, LPP amplitudes were enhanced for faces in negative contexts relative to neutral and positive contexts, as well as for self-related contexts in comparison to sender-related contexts. Together, these findings help to elucidate the psychophysiological mechanisms underlying the effects of emotional and self-referential contexts on the perception of surprised faces, which are characterized by distinctive ERPs.

Effects of valence and arousal on affective priming vary with the degree of affective experience denoted by words.

We investigated whether the effect of the valence and arousal of less or more affective experiential words on affective priming using event-related potentials (ERPs). The stimuli included less affective experiential (LE) words (Experiment 1) and more affective experiential (ME) words (Experiment 2) that were organized in an orthogonal design, with valence (positive and negative) and arousal (low and high) as factors in a lexical decision task. In Experiment 1, the results revealed no obvious effect of affective priming on response times (RTs) or ERPs for LE words. In Experiment 2, affective priming effects of ME words were influenced interactively by valence and arousal. Specifically, for positive ME words with high- and low-arousal, affectively incongruent trials were associated with longer RTs and enhanced late positive components (LPCs, 430-700 ms) compared with congruent trials (a positive effect). For negative ME words with low-arousal, no significant differences in RTs or LPC amplitudes were found between affectively congruent and incongruent trials (a null effect), whereas for negative ME words with high-arousal, the processing of congruent trials was associated with longer RTs and enhanced LPC amplitudes over that of incongruent trials (a reversal effect). On the one hand, our findings suggest that LE and ME words as primes produce different effects on the processing of subsequently presented targets. On the other hand, our findings further indicate that there seems to have a continuous transition from the spreading activation of ME words to an inhibition process in semantic memory along with their valence and arousal, which is involved in decision-making processes and memory-related stages.

The influence of self-construals on the ERP response to the rewards for self and mother.

Individual self-construal (independent vs. interdependent) could be temporarily modulated by the priming effect. Our previous studies have found that when Chinese participants gambled for mother and for self, outcome feedback evoked comparable neural responses between two conditions. However, it remains unclear if the response to rewards for mother and for self would differ after independence self-construal priming. In this study, we manipulated participants' self-construal (independent vs. interdependent) before a simple gambling task. The event-related potential (ERP) results reveal that when an interdependent self-construal was primed, the participants exhibited a comparable feedback-related negativity (FRN) elicited by outcome feedback for self and for mother. In contrast, independent self-construal priming resulted in a greater FRN elicited by outcome feedback for self than for mother. Meanwhile, the P3 component was insensitive to self-construal manipulation. These findings indicate the modulation effect of self-construal priming on the response to rewards for others.

The effect of emotionally valenced eye region images on visuocortical processing of surprised faces.

In this study, we presented pictorial representations of happy, neutral, and fearful expressions projected in the eye regions to determine whether the eye region alone is sufficient to produce a context effect. Participants were asked to judge the valence of surprised faces that had been preceded by a picture of an eye region. Behavioral results showed that affective ratings of surprised faces were context dependent. Prime-related ERPs with presentation of happy eyes elicited a larger P1 than those for neutral and fearful eyes, likely due to the recognition advantage provided by a happy expression. Target-related ERPs showed that surprised faces in the context of fearful and happy eyes elicited dramatically larger C1 than those in the neutral context, which reflected the modulation by predictions during the earliest stages of face processing. There were larger N170 with neutral and fearful eye contexts compared to the happy context, suggesting faces were being integrated with contextual threat information. The P3 component exhibited enhanced brain activity in response to faces preceded by happy and fearful eyes compared with neutral eyes, indicating motivated attention processing may be involved at this stage. Altogether, these results indicate for the first time that the influence of isolated eye regions on the perception of surprised faces involves preferential processing at the early stages and elaborate processing at the late stages. Moreover, higher cognitive processes such as predictions and attention can modulate face processing from the earliest stages in a top-down manner.

Social contexts modulate neural responses in the processing of others' pain: An event-related potential study.

Two hypotheses have been proposed regarding the response that is triggered by observing others' pain: the "empathizing hypothesis" and the "threat value of pain hypothesis." The former suggests that observing others' pain triggers an empathic response. The latter suggests that it activates the threat-detection system. In the present study, participants were instructed to observe pictures that showed an anonymous hand or foot in a painful or non-painful situation in a threatening or friendly social context. Event-related potentials were recorded when the participants passively observed these pictures in different contexts. We observed an interaction between context and picture in the early automatic N1 component, in which the painful pictures elicited a larger amplitude than the non-painful pictures only in the threatening context and not in the friendly context. We also observed an interaction between context and picture in the late P3 component, in which the painful pictures elicited a larger amplitude than the non-painful pictures only in the friendly context and not in the threatening context. These results indicate that specific social contexts can modulate the neural responses to observing others' pain. The "empathic hypothesis" and "threat value of pain hypothesis" are not mutually exclusive and do not contradict each other but rather work in different temporal stages.