RESUMO
A medical nanoplatform with small size, low cost, biocompatibility, good biodegradability, and, in particular, multifunctionality has attracted much attention in the exploration of novel therapeutic methodologies. As an emerging material of self-assembled porous structure, metal-organic frameworks (MOFs) have high expectations because of their special properties compared to traditional porous materials. Therefore, integration of MOFs and functional materials is leading to the creation of new multifunctional composites/hybrids. Photothermal therapy (PTT), using near-IR (NIR) laser-absorbing nanomaterials as PTT agents, has shown encouraging therapeutic effects to photothermally ablate tumors. However, the most of widely used PTT agents are inorganic materials and nonbiodegradable. Herein, uniform polypyrrole (PPy) nanoparticles (NPs) with good biodegradability were synthesized by a microemulsion method. The PPy NPs were further coated with the mesoporous iron-based MOF structure MIL-100 by interaction between PPy NPs and MIL-100 precursors at room temperature. As a multifunctional nanoplatform, an anticancer drug could easily be loaded into the mesopores of the MIL-100 shell. The PPy core, as an organic photothermal agent, is able to photothermally ablate cancer cells and improve the efficacy of chemotherapy under NIR irradiation. The composites showed an outstanding in vivo synergistic anticancer capacity. Our work could encourage further study in the construction of a synergetic system using MOFs and organic PTT agents.
Assuntos
Antineoplásicos/química , Portadores de Fármacos/química , Hipertermia Induzida/métodos , Nanopartículas/química , Fototerapia/métodos , Polímeros/química , Pirróis/química , Antineoplásicos/administração & dosagem , Doxorrubicina/administração & dosagem , Doxorrubicina/química , Portadores de Fármacos/efeitos da radiação , Feminino , Células HeLa , Humanos , Concentração de Íons de Hidrogênio , Raios Infravermelhos , Nanopartículas/administração & dosagem , Nanopartículas/efeitos da radiação , Polímeros/administração & dosagem , Pirróis/administração & dosagem , Neoplasias do Colo do Útero/terapiaRESUMO
Hollow hydroxyapatite nanospheres were prepared by a two-phase approach by controlling nucleation and crystal growth processes. The cavities of hollow HA provide potential applications as new kinds of containers for carrying, filling in, or encapsulating other materials, thus constructing a multifunctional system with good biocompatibility.