A feasibility study of 70 kV double low-dose coronary imaging technique in abdomen-fatty patients using dual-source CT.

Objective: To investigate the aplication of low contrast agent concentration and low tube voltage in coronary CTA on patients with high BMI (26kg/m228kg/m2). Methods: 60 patients with high BMI (26kg/m228kg/m2) were randomly divided into two groups: double low group A (n=30, tube voltage = 70 KV), double low group B (n=30, tube voltage = 70 KV), processed by SAFIRE iterative reconstruction with 270 mgI/ml contrast agent. Conventional group a (n=30, tube voltage = 120 KV), conventional group b (n=30, tube voltage = 120 KV), with filtered back projection (FBP) and 370 mg I/ml contrast agent. the image excellent index (FOM), the effective radiation dose (ED), mean CT value, signal-to-noise ratio (SNR), and contrast-to-noise ratio(CNR) between corresponding groups were compared. Result: There was no significant difference in subjective scores of coronary artery image quality between the two high BMI subgroups (P>0.05).The ED of group A (1.103±0.101 mSv) was significantly lower than that of group a (4.663±0.412 mSv) (P<0.001).There was no significant difference in mean CT value, SNR and CNR between the two subgroups (P>0.05).The image excellent index (FOM) of group A was higher than that of group a (P<0.05).The total iodine content and iodine injection rate in group A were lower than those in group a (P<0.001).The difference of subjective scores of coronary artery image quality between the two ultra-high subgroups was significant. The mean CT value, SNR and CNR of group B were lower than those of group b (P<0.05). The images of 14 patients in group B could not meet the diagnosis demand. Conclusion: It is feasible to reduce the tube voltage to 70KV in patients with abdominal BMI with high BMI (26Kg/m228Kg/m2), under the same conditions, the 70KV can not meet the daily diagnosis requirement.

Ladder-Like Low Iodine Delivery Rate Injection Protocols Based on BMI at 70 KV by Automated Tube Voltage Selection in Coronary CTA.

Objective: To evaluate the feasibility of reducing the injection velocity and volume of contrast agent according to BMI, and the effect of body weight (BW), body surface area（BSA）, body mass index（BMI），and blood volume (BV) on aortic contrast enhancement when the voltage of third-generation dual-source CT is selected at 70 KV. Methods: A total of 280 patients selected at 70 KV were randomly divided into an experimental group and a control group. Each group was divided into 7 subgroups according to BMI ≤20, 20-21, 21-22, 22-23, 23-24, 24-25, and 25-26. The experimental group uses 2.3/2.4/2.5/2.6/2.7/2.8/2.9 ml/s injection speed with 350 mgI/ml contrast agents according to the subgroups; injection time was fixed at 10 s. In the control group, the fixed injection flow rate was 3.5 ml/s, time was 12 s with a total of 42 ml. Subjects in both groups were inspected to adaptive prospective ECG-gating sequence scanning, and subjective and objective image quality of the two groups were compared using Student's t-test. BMI, BSA, and BV were calculated from the patient's body weight and height. We assess the relationship between aortic attenuation and BW, BMI, BV, and BSA using regression analysis or correlation analysis. Results: Significant differences exist in vascular enhancement between the two groups; SNR and CNR of objective image quality in the experimental group were lower than those in the control group (P < 0.05). Both groups had the same subjective image scores (P > 0.05). The number of vessels in the optimal enhancement range counts more in the experimental group than in the control group (χ2 value = 334.25, P ＜ 0.05). In the control group, a weak to medium correlation was seen between vascular enhancement and BMI (r = -0.20), BW (r = -0.42), BSA (r = -0.46), and BV (r = -0.48) (P ＜ 0.05 for all). Conclusions: Compared to BW, BSA, and BV, a weaker negative correlation exists between vascular enhancement and BMI when ATVS selects 70 KV. However, as a much easier way to operate, the stepped low flow and low-contrast agent injection based on BMI was feasible, and the image quality was more homogenized than that of the control group.