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Molecules ; 20(12): 21870-80, 2015 Dec 08.
Artigo em Inglês | MEDLINE | ID: mdl-26670221

RESUMO

In this study, in order to find novel biologically active pyrazole oxime compounds, a number of dichloro-allyloxy-phenol-containing pyrazole oximes were designed and synthesized according to the method of active group combination. All of the target compounds were confirmed by ¹H-NMR, (13)C-NMR and elemental analysis. In addition, bioassays showed that all of the newly synthesized compounds had no acaricidal activity against Tetranychus cinnabarinus and low insecticidal activity against Aphis craccivora at tested concentrations. However, most of them displayed excellent insecticidal activity against Oriental armyworm at a concentration of 500 µg/mL, and some designed compounds still exhibited potent insecticidal activity against Oriental armyworm even at the dose of 20 µg/mL, especially compounds 7f, 7n and 7p had 100%, 90% and 90% inhibition rates, respectively, which were comparable to that of the control pyridalyl.


Assuntos
Afídeos/efeitos dos fármacos , Desenho de Fármacos , Inseticidas/química , Inseticidas/farmacologia , Mariposas/efeitos dos fármacos , Oximas/química , Pirazóis/química , Pirazóis/farmacologia , Tetranychidae/efeitos dos fármacos , Compostos Alílicos/química , Animais , Estrutura Molecular , Oximas/farmacologia , Fenóis/química , Relação Estrutura-Atividade
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