1.
Org Lett
; 8(1): 115-8, 2006 Jan 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16381581
RESUMO
[reaction: see text] We describe a facile approach for effectively constructing the pentacyclic framework of subincanadine B. The seven-step assembly of tetracyclic ketone 14 featured Michael addition, Pictet-Spengler cyclization, and Dieckmann condensation. From this key ketone intermediate, two analogues of subincanadine B, i.e., 20-deethylenylated subincanadine B (27) and 19,20-dihydrosubincanadine B (31), were synthesized in four steps, respectively.
Assuntos
Etilenos/química , Alcaloides Indólicos/síntese química
2.
Org Lett
; 7(17): 3769-71, 2005 Aug 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16092871
RESUMO
We describe here a direct, efficient, one-step construction of gamma,gamma-difunctionalized gamma-butyrolactones from benzoins or benzaldehydes via a tandem reaction promoted by 1,3-dimethyl imidazolin-2-ylidene, an N-heterocyclic carbene (NHC). [reaction: see text]