[Organization of emergency health care to patients with tuberculosis].

Tuberculosis hospital No. 7 is an emergency general tuberculosis institution. In 2005, a total of 3847 patients were sent to the reception room; out of them 2045 were delivered by ambulances. That year, there were 568 emergency surgical interventions for comorbidity (n=343) and tuberculosis and its complications (n=225). The high availability of current diagnostic procedures and the presence of different skilled medical specialists enable one to promptly establish the diagnosis, which improves prognosis and reduces the length of hospital stay and the number of admission to tuberculosis and general hospitals. Tuberculosis hospital No. 7 provides diagnostic and therapeutic (primary) aids to patients who need no hospital care, which reduces the potential time of disability. The activity of tuberculosis hospital No. 7 is aimed at upgrading the quality of medical aid, reducing the number of wrongful admissions and the length of hospital stay, improving the occupational and social prognosis in patients with tuberculosis, and considerably saving the budgetary funds of the Moscow Department of Health Care.

[A category of patients with tuberculosis concomitant with HIV infection in an anti-TB facility]. / Kontingent VICH-infitsirovannykh bol'nykh tuberkulezom v protivotuberkuleznom uchrezhdenii.

A category of patients with tuberculosis concomitant with HIV infection, who were admitted for inpatient care to the infection department of Tuberculosis Clinical Hospital No. 7, Moscow, during 1996-2001, was analyzed. Peculiarities of the mentioned patients' category (205 subjects) were studied at the anti-TB facility. It was established that males (83.4%), aged 21-30 (48.9%), as well as unemployed (71%) prevailed. As much as 14% of them were homeless and 33% had a prison history. Drug-addiction (76%) and hepatitis C and B (77%) were found to be the key concomitant pathologies in them. HIV was primarily diagnosed at the anti-TB facility in 52% of patients, while tuberculosis had set on before HIV in 34.8% of patients. A major part of patients with tuberculosis concomitant with HIV, who were at the anti-TB facility, had early HIV stages. Specific features of the clinical course of tuberculosis were defined for patients with early HIV stages. It was established that tuberculosis concomitant with early HIV stages is deprived of any peculiarities except for the primary signs' stage, if it has the form of an acute infection. An exacerbation of the tuberculosis process, which quite often leads to its generalization and fatal outcome, can happen during the mentioned period due to a pronounced immunodeficiency.

[Seasonal and circadian fluctuations in blood biochemical indicators in mice in natural conditions and exposed to constant light]. / Sezonnye i sutochnye kolebaniia biokhimicheskikh pokazatelei krovi u myshei v estestvennykh usloviiakh i pri postoiannom osveshchenii.

The fluctuations of activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and those of the levels of protein, glucose, cholesterol, bilirubin, creatinine, blood urea nitrogen, K+, Cl-, Na+ in blood plasma of mice in natural conditions (NC) and exposed to constant light (CL) were studied in different seasons of the year (in January, April, July, October) on days 18, 24, 6 (at 12 o'clock). Most indices both in NC and CL animals had seasonal rhythm similar for each of them. This proves a primary effect of environmental geoclimatic factors of formation of circadian periodicals as compared to desynchronization in constant light revealed by Kosinor analysis in winter (acrophase from 14.16 till 16.32 o'clock) and autumn (acrophase from 23.03 til 4.40 o'clock). During the same seasons one can observe the maximum desynchronization influences of constant light, which leads to abrupt falling (to the 10-fold and more) of the fluctuations amplitude and in some cases to stabilization of circadian rhythm.

[Diurnal rhythm of rectal temperature in mice during various lighting conditions]. / Sutochnyi ritm rektal'noi temperatury u myshei pri razlichnom fotorezhime.

The study of circadian rhythm of rectal temperature (t degrees) during 4.5 months in mice under conditions of continuous lighting (LL) and natural alteration of day and night (LD), considering astronomic time of sunrise and sunset, revealed the following regularities: In winter and in summer t degrees maximum in LD was marked at the beginning of the dark period of time (twilight period), t degrees minimum was observed at the end of the dark period. In winter, when the dark period lasts 14-15 hours, t degrees falls from maximum to minimum during all the dark period (12-14 hours), and in summer, when the period of darkness lasts 6 hours, t degrees falls only during 2 hours. In spring t degrees minimum shifts to the middle of the light period. Under conditions of LL, circadian rhythm of t degrees "splits" periodically into bimodal with periods of 10-14 hours. Long keeping (during 4.5 months) under conditions of LL results in levelling of t degrees circadian rhythm. The character of t degrees circadian rhythm in laboratory animals (mice) is not inverted to that in human beings.