[Immunodepressive properties of antineoplastic agents]. / Immunodepressivnye svoistva nekotorykh protivoopukholevykh preparatov.

Experiments on CBA mice immunized with sheep red blood cells have shown that paphencyl, promycil, prospidin and imidazole-4-carboxamide decrease the number of IgM-antibody-forming cells in mouse spleens during the primary immune response. The highest immunodepressant effect was exhibited by paphencyl, while the least by prospidin. The maximum inhibition of the immune response was observed on paphencyl and promycil administration 24 hours after the immunization, that on prospidin administration 24 hours prior to antigen exposure, and that on imidazole-4-carboxamide administration 24 hours prior and 48 hours after the antigenic stimulation. The degree of antibody genesis suppression depends on the dose of paphencyl, promycil and prospidin and does not depend on the dose of imidazole-4-carboxamide. Paphencyl significantly diminishes the number of hemopoietic stem cells in mouse spleens, while prospidin was less active in this respect.

[Intersatellite connections of the human acrocentric chromosomes that participate in associations]. / Mezhsputnichnye sviazy akrotsentricheskikh khromosom cheloveka, uchastvuiushchikh v assotsiatsiiakh.

Intersatellite connections between acrocentric chromosomes in associations were revealed by the method of thermal ammoniacal silver staining. The associations were allotted to the corresponding groups on the basis of the number of chromosomes. Distribution of D- and G-chromosomes in associations was studied on the basis of 714 associations from 500 metaphase plates of 10 normal individuals. The hypotheses of hypergeometric, binomial, Poisson, uniform and exponential distribution laws of D- and G-chromosomes in associations were rejected. The hypothesis of normal distribution was not rejected. The principal characteristics of normal distribution law were found. The distribution law of the number of D- and G-chromosomes in associations was written analytically; the central moments and other characteristics were presented.