RESUMO
The influence of autologous blood, rheopolyglucinum with mannitol and of two combined blood corrigents on tubular secretion (with respect to 131I-hippuran excretion) and glomerular filtration (with the use of 169Yb-DTPA) was studied in experiments on white mice with "irreversible" hemorrhagic shock. It was established that autoblood transfusion led to an insignificant recovery of tubular secretion and glomerular filtration in shock. Rheopolyglucinum with mannitol improved, to some extent, the kidney function, while the combined blood corrigents including rheopolyglucinum, mannitol, crystalloids and sodium succinate contributed to more complete recovery of the kidney function. The highest effect was recorded when the blood corrigent was supplemented by a compound resuming the electron transport along the mitochondrial respiratory chain. The use of the autoblood with combined blood corrigents (1:4) in severe hemorrhagic shock led to the same degree of recovery of tubular secretion and glomerular filtration as combined blood corrigents alone.
