Synthesis and evaluation of anti-yellow fever virus activity of new 6-aryl-3-R-amino-1,2,4-triazin-5(4H)-ones.

Yellow fever disease is one of public health concerns in the tropics. Despite its significant medicinal and economic impact among large groups of the population, there is a lack of effective treatment against yellow fever. In this regard, here we describe the synthesis of a series of new 6-aryl-3-R-amino-1,2,4-triazin-5(4H)-ones and evaluation of their in vitro inhibitory activity against yellow fever virus. Among all tested compounds 4 derivatives possessing strong inhibitory activity at µM concentrations were identified. All the active compounds revealed a good toxicity profile. These facts make the compounds interesting candidates for further evaluation of their efficacy in the treatment of yellow fever virus infection in vivo.

Composition of fatty acids in Centaurea cyanus (L.).

The presented study shows the composition of fatty acids (FA) in flowers and herb of wild and cultivated cornflower (Centaurea cyanus (L.)). The analysis was performed by gas chromatography (GC) with a method using internal normalization. Together 13 fatty acids were identified in both types of cornflower herb. Unsaturated fatty acids, particularly, linoleic, linolenic, and oleic acids, were prevailing in cultivated cornflower flowers and herb, as well as in wild cornflower flowers. Palmitic acid was the most abundant saturated FA.