RESUMO
OBJECTIVE: To research the effect of total saponins of Yinfenglun on uterine. METHOD: Models of uterine inflammation were established to observe the effect of total saponins of Yinfenglun. Uterine contractive effects were studied on rats in vitro and on rabbit in vivo. Weight of uterus and levels of estrogen and progestogen were determined. RESULT: Total Saponins of Yinfenglun had the ameliorated tendency to metritis of model rats, and increased the contractive range and motorricity of uterine of rats in vitro and of rabbit in vivo. The effect to uterus in vivo maintained longer. Total saponins of Yinfenglun could increase the weight of uterus and have an increased tendency on the content of estrogen, but not the level of progestogen. CONCLUSION: There are obvious effects on uterine of total saponins of Yinfenglun, which are related to its clinical use.
Assuntos
Estradiol/sangue , Lamiaceae , Saponinas/farmacologia , Contração Uterina/efeitos dos fármacos , Útero/anatomia & histologia , Animais , Feminino , Inflamação/patologia , Lamiaceae/química , Camundongos , Tamanho do Órgão/efeitos dos fármacos , Plantas Medicinais/química , Progestinas/sangue , Coelhos , Distribuição Aleatória , Ratos , Ratos Wistar , Saponinas/isolamento & purificação , Doenças Uterinas/patologiaRESUMO
OBJECTIVE: To research the hemostatic effect of total saponins of Yinfenglun. METHOD: Bleeding time and volume were deteminded in mice after tails being cut. Clotting times were researched on mice, rats and dogs. Hemostatic mechanism total saponins of Yinfenglun were studied on plasma recalcified time, PT, KPTT and ELT. RESULT: TSY at different doses could markedly shorten bleeding time, reduce bleeding volume in mice. TSY also could shorten clotting time of mouse, rat and dog. TSY could influence both intrinsic coagulatian system and extrinsic coagulatian system,and had no effect of antifibrinolysis. CONCLUSION: There were obvious hemostatic effect of total saponins of Yinfenglun.
