Association between Kidney Donor Risk Index, kidney graft function and histological changes in early post-transplant graft biopsy.

Background: Proper assessment of donor organ quality is crucial for optimal kidney allocation and best long-term outcomes. The aim of this study was to analyze the association between the Kidney Donor Risk Index (KDRI) and histological parameters in early post-transplant graft biopsy in a Polish cohort of kidney transplant recipients. Methods: In 418 consecutive kidney transplant recipients, a histological evaluation of very early [at median 11 (9-13) post-transplant day] protocol core needle biopsy was performed and analyzed according to the Banff classification. Subjects were divided into quartiles of the KDRI value. Kidney graft function, patient and graft survival were also analyzed over a median follow-up period of 44 (26-56) months. Results: There was a significant trend toward greater intensity of chronic histology changes along the KDRI quartiles (χ2 = 20.8; P < .001), including interstitial fibrosis, tubular atrophy, mesangial matrix increase and arteriolar hyalinosis. Stepwise multivariate regression analysis revealed that only higher KDRI value independently increased the severity of chronic graft injury (rpartial = 0.340, P < .001). KDRI values were valuable in the determination of both early and long-term graft function. Conclusion: The KDRI values correlate with chronic histological changes found in early post-implantation kidney biopsies and can also be helpful in the prediction of graft outcome.

Oral non-specific lesions in patient with Crohn's disease - a case report.

Crohn's disease (CD) is a chronic and granulomatous inflammatory disease of the entire gastrointestinal tract. The etiopathogenesis is not fully elucidated. The most common symptoms in the active phase of the disease include abdominal pain, prolonged diarrhea, fever, fatigue, malaise and weight loss. Oral manifestations of CD are classified into specific for CD with granulomatous changes and non-specific ones. This rare extraintestinal manifestation of CD in adults may precede gastrointestinal tract involvement, occur together or appear after years of its duration. Oral lesions can be initiated by malnourishment, poor absorption of nutrients or side-effect of medications. A CASE REPORT: We describe a 28-year-old female with a 9-years CD history, who presented in the active disease with oral lesions. They were classified as non-specific ones, and included oral candidiasis, irregular erythematous patches on the cheek mucosa, exfoliative lip inflammation, and angular cheilitis. The patient was treated with azathioprine, and since the last exacerbation of symptoms, induction therapy with adalimumab, (anti-TNF-alpha), has been prescribed. Nystatin was applied to treat the oral lesions, based on the microbiological assessment of the Candida albicans susceptibility, and symptomatic treatment. After a two-week treatment the oral mucosa was healed and angular cheilitis showed marked improvement compared to the initial presentation. CONCLUSIONS: The young female with active CD presented the nonspecific lesions in the oral cavity. The lesions coexisted with the active inflammatory process in the intestinal tract with characteristic clinical symptoms, and were associated with sideropenic anemia. The implementation of the local therapy, systemic CD treatment and supplementation of micronutrient deficiencies have led to a healing of the oral lesions. We emphasize a personalized approach to treatment and close cooperation between the dentist and the gastroenterologist.

Profile and bioconcentration of minerals by King Bolete (Boletus edulis) from the Plocka Dale in Poland.

This study aimed to provide basic data on the composition of metallic elements, including toxicologically important Cd and Hg, in popular and prized wild King Bolete mushrooms. We investigated the importance of soil substratum as a source of these metals. ICP-OES and CV-AAS were applied to determine the profile of Al, Ba, Ca, Cd, Cu, Fe, Hg, K, Mg, Mn, Na, Sr and Zn in caps and stipes of King Bolete mushroom and in the surface layer of soil (0-10 cm) from the Plocka Dale area of Poland. Hg, Cu, Cd, Zn, Mg and K exhibited bioconcentration factors (BCF) > 1. Specifically, Hg, Cu and Cd (mean BCFs for caps were 110, 19 and 16, respectively) were efficiently bioconcentrated by King Bolete, while other elements were bioexcluded (BCF < 1). Cadmium was present in the caps at mean levels of 5.5 ± 2.4 mg kg(-1) dry weight (dw) and mercury at levels of 4.9 ± 1.4 mg kg(-1) dw, both occurring at elevated concentrations in those King Bolete mushrooms surveyed.

[Oral health status and dental service needs of diabetic patients]. / Stan zdrowia jamy ustnej i potrzeb leczniczych chorych na cukrzyce.

INTRODUCTION: Diabetes mellitus is a serious metabolic disease causing systemic disorders that are also noticeable in the oral cavity, as first described by Seifert in 1862. Manifestations in the oral cavity include abnormal development of dentition, increased frequency and intensity of caries, pathologies of the oral mucosa, salivary glands and parodontium, as well as atrophic changes in alveolar processes. The role of diabetes in the etiopathogenesis of lesions in the oral cavity remains the focus for research, discussions, and controversies. The present work was undertaken to: 1) describe differences in oral health status between patients with diabetes mellitus type 1 and 2 depending on glycemic control; 2) determine the severity of lesions in the oral cavity depending on the duration of diabetes mellitus; 3) establish the effect of visits to a sanatorium on oral health status and dental service needs; 4) determine the effect of gender on oral health status and dental service needs in diabetic patients; 5) establish the relation between the place of residence, oral health status, and dental service needs in diabetic patients. MATERIAL AND METHODS: The study was done in 300 patients with diabetes mellitus, aged 17 to 85 years, including 154 females and 146 males, visiting a diabetology sanatorium. The type of diabetes, duration of diabetes, and adequacy of glycemic control were determined. The DMFT value, caries treatment index, oral hygiene status, parodontal status according to Bellini, type of dental defects according to Galasinska, and oral mucosa status according to Newton with reference to the baseline status according to Spiechowicz were established. The type and condition of prostheses classified as fixed, removable, butt joint, and complete was established. The place of residence of the patient, whether town or village, was taken into account. The number and frequency of visits to a sanatorium were recorded. RESULTS: It was found that there are differences between oral health status in patients with type 1 and type 2 diabetes mellitus. Uncontrolled glycemia, regardless of the type of diabetes, exerts an adverse effect on oral hygiene status. During diabetes, pathologic lesions develop in the oral cavity. Visits to a diabetology sanatorium were associated with improved oral health status and reduced dental service needs. A strong correlation was noted between gender, oral health status, and dental service needs, to the disadvantage of female patients. There was also a relation between the place of residence (town, village), oral health status, and dental service needs, to the advantage of patients residing in towns.

Influence of tamoxifen on the mandible bone and hard teeth tissues of animals.

Tamoxifen, protactedly used, can cause disadvantageous changes in the bones and in the hard teeth tissues. The aim of this paper was to define to what extent tamoxifen given to the animals influences the structure of the mandible bone and the hard teeth tissues.