[Experimental study of photodynamic treatment with Laminaria japonica and Fucus sp for sarcoma M-1].

In the course of photodynamic treatment with supernatants of Laminaria japonica and Fucus sp the former was found to significantly inhibit the growth of experimental tumor M-1.

[Influence of Laminaria japonica and fucus on hemostasis and sarcoma M-1 growth in Wistar rats].

The study was concerned with the effects of brown seaweeds on hemostasis and sarcoma M-1 growth in rats. Laminaria japonica and focus were shown to exert anticoagulant action to inhibit carcinogenesis. They may be used for adjuvant therapy of tumors.

[Modification of an antitumor action of photodynamic therapy with anticoagulant drug fenylin].

Noninbred rat experiments with M-1 tumor have found that combination of fenylin with photodynamic therapy produced a 1.5-fold slowing down in the growth of the tumor compared to the control animals on day 15 and 21 after the treatment.

[Immunogenic peptide neogen stimulates postradiation recovery thrombopoiesis]. / Immunomoduliator neogen stimuliruet postradiatsionnoe vosstanovlenie trombotsitopoéza.

In experiments on mice F1 total exposed to gamma-irradiation at the 5.0 Gy, showed that a intraperitoneal injection neogen at the dose 10 micrograms/kg oue time at the day and night during the 8 days after irradiation results in recovery of the number blood platelets and time issue of blood from standard wound to normal level on the week by compare with irradiated control animals.

[An experimental study of the hemostatic system in acute radiation sickness exacerbated by skin burns]. / Eksøeromental'noe issledovanie sistemy gemostaza pri ostroi luchevoi bolezni, otiagoshchennoi ozhogom kozhi.

The experiments on Wistar rats and mice (C57B16)F1 exposed to gamma irradiation at the doses of 4,5 to 7,5 Gy, alone and in combination with a III-B skin burn of 10-30% skin surface, showed that a combined injury results in a higher death rate. On a background of the bone marrow hemocytogenesis depression, a syndrome of disseminated intravascular blood coagulation and the irradiation-induced hemorrhagic syndrome develop. It was shown that the bone marrow depression and hemostasis disorders play an important role in the thanatogenesis of a combined radiation and thermal injury. The problems of diagnosis and therapy are discussed.

[Antithrombogenic activity of blood vessel walls in the pathogenesis of metastasis in tumor-bearing animals]. / Antitrombogennaia aktivnost' stenki krovenosnykh sosudov v patogeneze metastazirovaniia u zhivotnykh-opukholenositelei.

The purpose of this work was to examine the relationship between the antiaggregatory activity of the vascular wall and the metastatic spread of experimental tumors. Rats with the tumor "Myosarcoma-1" displayed, on the average, a 30% reduction in the antiaggregatory activity of the aortic wall. Three-week of the animals with a combination of the drugs dipyridamole (0.84 mg/kg per os), phytin (14 mg/kg per os), glutamic acid (28 mg/kg per os) restored the antiaggregatory properties of the vascular wall virtually up to the control values. The similar result was observed with cordarone (60 mg/kg intraperitoneally): the antiaggregatory properties of the vascular wall increased on the average by 50%. The metastatic spread of tumor cells in mice with Lewis carcinoma of the lung decreased on the average twice while treating them with these agents. The findings point to the fact that drug correction of the antiaggregatory activity of the vascular wall reduces the rate of metastatic spread.

[An experimental study of the early changes in the body after simultaneous radiation exposure at a low dose and stress]. / Eksperimental'noe izuchenie rannikh izmenenii v organizme posle odnovremennogo vozdeistviia radiatsii v maloi doze i stressa.

In experiments in rats it was shown that simultaneous effect of low dose radiation (12.9 cGy) and stress (immobilization) resulted in early adaptation-like changes (decrease in body weight, increase of adrenal gland weight, decrease in thymus weight, slowing down of blood coagulation). At the same time irradiation of immobilized animals prevented stressogenic disturbances such as depression of antiaggregation activity of vascular wall and decrease in leucocytes level. This was accompanied by the acceleration of mobilization of compensatory properties, that presumably is a basis for positive effects under combined influence.

[Modification to the functional status of the hemostatic system with the use of berberine sulfate]. / Modifikatsiia funktsional'nogo sostoianiia sistemy gemostaza pri primenenii berberina sul'fata.

The effect of berberin sulfate (single and chronic administration during 30 days in doses of 0.14-80 mg/kg) on the functional state of hemostasis system was studied on gamma-irradiated (dose 5.0 Gy) and intact Wistar rats and mice (CBA x C57BL)F1. Administration of the drug increases the number of thrombocytes, decreases the activity of factor XIII and promote blood coagulation.

[Hemopoiesis stimulation by low-intensity laser radiation in acute radiation sickness exacerbated by thermal trauma]. / Stimuliatsiia gemopoéza nizkointensivnym lazernym izlucheniem pri ostroi luchevoi bolezni, otiagoshchennoi termicheskoi travmoi.

In experiments with gamma-irradiated (dose of 7.0 Gy) and burned (III-B grade, 10% skin injury) hybrid mice the haemopoietic effect (1.5-2-fold increase) of low-intensity laser irradiation (LILI) has been detected. At the same time there was no effect of LILI on normal animals.

[Hemostasis in hens with exposure to low-dose gamma-irradiation in the embryonal period]. / Sistema gemostaza kur pri deistvii malykh doz gamma-oblucheniia v émbrionalnom periode.

Exposure of hen's eggs to irradiation by doses 0.05-1.66 Gy (dose rate 2.56x10-4 Gy/s) in early embryonal period (1st day of incubation of eggs doesn't essentially affect on indices of functional state of haemostasis system of two-month aged individuals, except the activation of contact phase of blood coagulation, in which a hypercoagulation shift within normal fluctuations has been noted.

[The stimulation of postradiation thrombocytopoiesis by low-intensity laser radiation]. / Stimuliatsiia postradiatsionnogo trombotsitopoéza nizkointensivnym lazernym izlucheniem.

In experiments with gamma-irradiated (LD50/30) F1(CBA x C57Bl) hybrid mice, thrombocytopoietic effect of low-intensity laser radiation has been detected. The data obtained may be used in developing modes of haemopoiesis stimulation in a gamma-irradiated organism.