Evaluation and Intervention for Frailty in Old Adults (review) / 中国康复理论与实践

@#Frailty is a pre-disabled stage and associated with increased vulnerability to adverse health outcomes. Frailty has high preva-lence in older population. There are 2 principal emerging models of frailty, which are the phenotype model and the frailty index model. Many studies have developed tools to detect frailty, including self-report scales, such as PRISMA-7, Groningen Frailty Indicator (GFI), Ed-monton Frail Scale (EFS) and Simple Frailty Questionnaire (FRAIL);and single assessments, such as gait speed, timed up-and-go test, grip strength, pulmonary function test. Intervention of exercise and/or nutrition are benefical for frail older adults.

Effects of chronic and acute training on glucocorticoid receptors concentrations in rats.

The effects of chronic endurance training and acute exercise on glucocorticoid receptors were investigated in rats. For chronic endurance training, rats were exposed to progressive running training on a motor-driven treadmill for 3, 5 and 7 weeks, twice a day and 6 days a week. The samples were taken, 34-36 hours after the last exercise bout. Some of the 7-week training rats were killed by decapitation 7 days following the last exercise bout. The glucocorticoid receptors in hepatic cytosol in 5-week and 7-week rats decreased as compared to the sedentary control. There was no significant difference between the glucocorticoid receptors in hepatic cytosol in some of the 7-week rats those who had stopped training for 7 days and those in the controls. The chronic endurance training did not lead to change of the apparent dissociation constant (Kd). The changes of glucocorticoid receptors after acute exercise have also been investigated and it showed profound decreases of glucocorticoid receptors in renal and myocardial cytosol in low intensity (swimming without an extra weight for 60 minutes) and high intensity (swimming with a weight equal to 6% of body mass for 60 minutes) training groups. The decreases in glucocorticoid receptors in renal and myocardial cytosol were less prominent after low intensity training. These results demonstrated that both acute exercise training and chronic endurance training could lead to a decrease in glucocorticoid receptors, which was in a training intensity- and training load volume-dependent manner, and the changes in glucocorticoid receptors during exercise training were reversible.

Changes of T-helper1/T-helper2 Special Cytokine mRNA Expression during 5 Weeks Incremental Load Training / 中国运动医学杂志

Objective To explore the exercise induced immunity changes during incremental load training from the view of the expression of helper T cells (Th) mRNA. Methods Using the technique of real-time quantified PCR to observe T-helper-special cytokine mRNA of peripheral blood mononuclear cell dynamically in healthy young male who have been trained with incremental exercise for five weeks. Results There was no obvious change in IL-2 mRNA during five weeks training. Meanwhile IL-4 mRNA increased greatly in the second, third and fourth week. IFN-? mRNA as well as IFN-? mRNA/IL-4 mRNA increased remarkably in the third, fourth and fifth week . Conclusion The expression of T-helper1/ T-helper2 cytokine mRNA were up-regulated after five weeks and the subjects were gradually adapt to the increased load which indicated the enhancement of immunity function .