RESUMO
The costs of medication represent a great part of total health costs in the Czech Republic. In the sphere of drugs, as in other segments of the health sector in this country, constant pressure is put on the growth in expenditure irrespective of the actual growth of the economy. The article is a reaction to the paper by Adam Z et al, Improvement in the results of treatment of selected blood diseases and changes in the costs of such treatment Issues for economists and other experts. The article presents data on the trend towards a growth of costs in the health sector and the causes of such a trend, with special focus on expenditure for expensive cancer drugs. Also included are proposals for financing options for cancer drugs. Rather than to make a direct recommendation for Czech health policy, the author's intention is to provoke discussion about the options for a sustainable system of Czech drug policy financing.
Assuntos
Custos de Medicamentos , República Tcheca , Custos de Medicamentos/tendências , Custos de Cuidados de Saúde/tendências , Humanos , Legislação de Medicamentos , Alocação de RecursosRESUMO
The nitric oxide/cGMP system has been shown to play a crucial role in the mechanism of learning and memory. The aim of the present study was to investigate whether the inhibition of NO synthase in brain regions leads to alterations of spontaneous behavior in rats. Male Wistar rats were treated with NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) at the dose of 40 mg/kg/day. After 4 weeks of L-NAME treatment, NO synthase activity was significantly decreased by 75% in the cerebellum, by 71% in the cerebral cortex and by 72% in the thoracic spinal cord. Decreased NO synthase activity in the nervous tissue was associated with decreased motor horizontal and vertical activities as well as by lowered frequency of sniffing, cleaning and defecation. It is concluded that the inhibition of NO synthase activity has a suppressive effect on spontaneous behavior of rats.