RESUMO
Human metapneumovirus (hMPV) is a paramyxovirus that causes respiratory tract infections ranging from mild upper airway infection to severe pneumonia. Patients with haematological disease, especially haematopoietic stem cell transplantation (HSCT) recipients, are more likely to develop more severe infections. We describe three cases of hMPV infection in HSCT patients. The most reliable diagnostic procedure for hMPV is multiplex ligation-dependent probe amplification (MLPA) on a nasopharyngeal swab. Sensitivity and specificity of MLPA to detect hMPV is high and time to diagnosis is short. A number of other respiratory pathogens can be tested in one test run. Treatment is mainly supportive and only a few antiviral agents are available for treating paramyxovirus infections. Ribavirin and immunoglobulins were reported to be effective in cases of HSCT patients with hMPV pneumonia but their efficacy has not been studied in randomised trials.
Assuntos
Transplante de Células-Tronco Hematopoéticas , Hospedeiro Imunocomprometido/imunologia , Infecções por Paramyxoviridae/imunologia , Infecções Respiratórias/imunologia , Idoso , Antivirais/uso terapêutico , Feminino , Humanos , Imunoglobulinas Intravenosas/uso terapêutico , Fatores Imunológicos/uso terapêutico , Leucemia Mieloide Aguda/terapia , Leucemia Plasmocitária/terapia , Masculino , Metapneumovirus/genética , Pessoa de Meia-Idade , Mieloma Múltiplo/terapia , Reação em Cadeia da Polimerase Multiplex , Nasofaringe/química , Infecções por Paramyxoviridae/diagnóstico , Infecções por Paramyxoviridae/terapia , RNA Viral/análise , Infecções Respiratórias/diagnóstico , Infecções Respiratórias/terapia , Ribavirina/uso terapêutico , Sensibilidade e EspecificidadeRESUMO
A young woman has started cancer treatment because of a Hodgkin's lymphoma. After four months of chemotherapy, a PET scan showed an unexplained hotspot in the right lower abdomen. This was later explained by an unsuspected pregnancy. Our case emphasizes the importance of a pregnancy test in all women in the reproductive age before starting cancer treatment.
