[Supramolecular regulation of the activity of some oxidoreductases in the norm and in pathology]. / Nadmolekuliarnaia reguliatsiia aktivnosti nekotorykh oksidoreduktaz kletki v norme i patologii.

Regulation metabolism in a cell is realised by enzymes arranged into supramolecular complexes. Lactate dehydrogenase (LDH) and alcohol dehydrogenase (ADH) are involved into formation of various supramolecular complexes. It is supposed that oxidoreductases LDH and ADH can form uniform functional supramolecular complex, exerting essential influence on redox potential of the cell.

[Molecular mechanisms of metabolic adaptation in pathological changed liver during toxic hepatitis ]. / Molekuliarnye mekhanizmy metabolicheskoi adaptatsii patologicheski izmenennoi pecheni pri toksicheskom gepatite.

Possible molecular mechanisms underlying changes in catalytical properties of alcohol dehydrogenase (ADH) and lactate dehydrogenase (LDH) were studied at toxic hepatitis. The development of toxic hepatitis is accompanied by significant changes in the activity of ADH and LDH assayed in subcellular fractions and kinetic characteristics of these enzymes. This can result in an increase cellular level of acetylaldehyde and lactate which promotes the development of liver cirrhosis.

[The role of cytochrome c in preventing postresuscitation functional disorders of the central nervous system]. / Rol' tsitokhroma c v preduprezhdenii postreanimatsionnykh narushenii funktsional'nogo sostoianiia tsentral'noi nervnoi sistemy.

The effect of intracarotid injection of cytochrome c on the course of the early postresuscitation period was studied in experimental animals (albino rats) after 5-min clinical death from acute blood loss. It was shown that the drug normalizes the disturbed metabolic processes in the brain, reduces the structural changes consequent upon total ischemia, stabilizes the activity of the cardiovascular system and, as a result of this, contributes to restoration of functional activity of the central nervous system in the early postresuscitation period.

[The mechanism of action of chorionic gonadotropin on lactate dehydrogenase activity]. / K mekhanizmu deistviia khorionicheskogo gonadotropina na aktivnost' laktatdegidrogenazy.

The purpose of this report is to demonstrate that chorionic gonadotropin (CG) interacts nonspecifically with lactate dehydrogenase changing its catalytic activity. The binding in vitro of CG (5 mg/ml) to the enzyme is accompanied by conformational changes of its protein and kinetic characteristics. It may be possible that chorionic gonadotropin exercises a controlling influence on lactate dehydrogenase activity in the cell.

[Respiratory function in newly developed stenocardia and in long-term course of ischemic heart disease]. / Funktsiia vneshnego dykhaniia pri vpervye voznikshei stenokardii i pri dlitel'no tekushchei ishemicheskoi bolezni serdtsa.

External respiration was evaluated in coronary patients with varying duration of the disease. Bronchial obstruction was not a rare finding especially in patients with a long history of angina pectoris. In most of the patients the obstruction was reversible as shown by respiration parameters upon inhalation of broncholytics with various mechanisms of action. Respiratory disorders were not associated with dyspnea, derangement of gaseous exchange and could not be attributed to attendant bronchopulmonary diseases, smoking as such patients had not been entered in the study. A 3-year follow-up was not indicative of spontaneous progression of bronchial obstruction.

[Prognosis for ischemic heart disease patients with episodes of painless myocardial ischemia alternating with rare attacks of stenocardia. The correlation between ischemia and ventricular extrasystole]. / Prognoz u bol'nykh ishemicheskoi bolezn'iu serdtsa s épizodami bezbolevoi ishemii miokarda, chereduiushchimisia s redkimi pristupami stenokardii. Sootnoshenie ishemii i zheludochkovoi ékstrasistolii.

Repeated annual 24-hour Holter's ECG monitoring sessions were used as a basis for 4-year follow-up of 108 male coronary patients with episodes of painless myocardial ischemia in the course of their everyday routines, and 144 control patients showing no signs of transient asymptomatic ischemia at 24-hour Holter's ECG monitoring. Four years of follow-up demonstrated no differences between the two groups, compared with respect to the incidence of myocardial infarction and associated mortality as well as aggravations of coronary heart disease, in terms of clinical pattern of the disease, the incidence of acute coronary episodes and survival rates. There were no sudden deaths in either of the groups. Transient painless myocardial ischemic episodes are shown to carry no additional risk of myocardial infarction and sudden death in elderly coronary patients with occasional anginal attacks.

[Transitory changes in the ST interval of ischemic heart disease patients with stenocardia during 24-hour ECG monitoring]. / Prekhodiashchie izmeneniia segmenta ST u bol'nykh ishemicheskoi bolezn'iu serdtsa so stenokardiei vo vremia sutochnogo monitorirovaniia EKG.

Five hundred and seventy coronary patients of both sexes, showing occasional attacks of angina of effort, were subjected to 24-hour ECG monitoring sessions at 1 week intervals during 1 month. Ischemic episodes were detected in 139 (24%) patients. A total of 362 ischemic episodes were already detected at the first ECG monitoring session, the majority of those (97%) being painless. Magnitude and duration of ST depression were similar in the absence of pain and during anginal attacks. Repeated sessions demonstrated considerable spontaneous variability in the frequency of ischemic episodes.

[Effect of hyperbaric oxygenation on the extrasystole in ischemic heart disease patients]. / Vliianie giperbaricheskoi oksigenatsii na ékstrasistoliiu u bol'nykh ishemicheskoi bolezn'iu serdtsa.

A study of the effect of hyperbaric oxygenation (HBO), applied as single sessions or a treatment course, on cardiac rhythm in 82 coronary patients with chronic extrasystole demonstrated positive therapeutic effect to be achieved after the first 5 or 6 HBO sessions in all patients. Further treatment may provoke an aggravation of arrhythmia in some patients. Positive antiarrhythmic effect of a complete HBO course is doubtful, where ectopic activity is increased following the 7th session. There is a correlation between the results of ECG monitoring from the hyperbaric chamber, from session 7 onwards, and 24-hour ECG recording before and after a HBO course. As shown by 24-hour ECG monitoring, positive effect was obtained in 67% of patients with ventricular extrasystole, the number of ventricular extrasystoles remained basically unchanged after a HBO course in 17%, and ectopic activity increased in 15.4%.