Statistical significance levels of nonparametric tests biased by heterogeneous variances of treatment groups.

The statistical significance levels of the Wilcoxon-Mann-Whitney test and the Kruskal-Wallis test are substantially biased by heterogeneous variances of treatment groups--even when sample sizes are equal. Under these conditions, the Type I error probabilities of the nonparametric tests, performed at the .01, .05, and .10 significance levels, increase by as much as 40%-50% in many cases and sometimes as much as 300%. The bias increases systematically as the ratio of standard deviations of treatment groups increases and remains fairly constant for various sample sizes. There is no indication that Type I error probabilities approach the significance level asymptotically as sample size increases.

Cyclic interdigestive pancreatic exocrine secretion: is it mediated by neural or hormonal mechanisms?

Cyclic interdigestive exocrine pancreatic secretion and duodenal motility are closely linked. However, the mechanisms controlling this association are not well understood. The aim of this study was to determine whether a neural or hormonal mechanism controls the temporal association of interdigestive secretion and duodenal motility. In five dogs, the pancreas was autotransplanted to the pelvis with anastomosis of the pancreatic duct orifice to the bladder. Electrodes were positioned to monitor motility patterns of the in situ duodenum. After 10 days, dogs were studied on four occasions during fasting. Pancreatic output of amylase activity continued to cycle, but the periodicity of enzyme peaks (mean +/- SE) was different from the period of the duodenal migrating motor complex (MMC) (60 +/- 3 vs. 125 +/- 7 minutes; P less than 0.05). When grouped according to phase of duodenal MMC, amylase output per 10 minutes during phase I was significantly less than the outputs during phase II or III (135 +/- 52, 214 +/- 78, and 228 +/- 73 x 10(3) U; P less than 0.05). However, there was no temporal relationship of the cyclic output of amylase to duodenal phase III. No differences were found when amylase output was analyzed for the 30 minutes before phase III compared with the 30 minutes after phase III (687 +/- 253 vs. 378 +/- 110 x 10(3) U; P greater than 0.05). Plasma motilin concentrations varied with duodenal MMC, but no relationship existed between plasma motilin or plasma pancreatic polypeptide and peaks in amylase output. This study suggests that the close temporal coordination of interdigestive pancreatic exocrine secretion and duodenal motility is controlled primarily by a neural mechanism.

Further evidence for Coren and Hakstian's "Methodological implications of interaural correlation: count heads not ears" and an alternative correction formula.

Coren and Hakstian (1990) identified a serious methodological problem that arises in auditory research because of interaural correlation. When measures from both ears of the subjects are pooled together in an experimental design that assumes independence of measures, there can be spuriously high apparent statistical significance. The present paper provides further evidence in support of Coren and Hakstian's argument and also derives a formula that effectively corrects inflated test statistics resulting from interaural correlation. This formula is a special case of a more general one that applies in many other experimental contexts in which nonindependence of measures is a problem. We found that statistical tests based on our formula have somewhat greater power to detect differences than the kind of correction method advocated by Coren and Hakstian.

Thermoluminescent determination of prehistoric heat treatment of chert artifacts.

In recent years archeologists have become interested in the extent to which prehistoric peoples heat-treated chert prior to shaping it into tools. Thermoluminescent determination of the radiation dose accumulated by an artifact since it was formed or last heated provides a simple, reliable test for such heat treatment. This test can be applied to single artifacts without the need for raw source material for comparison. Results on 25 artifacts from four sites indicate that, for many chert sources, color and luster are not useful indicators of heat treatment by prehistoric peoples.

Uranium distributions in archeologic ceramics: dating of radioactive inclusions.

Small mineral grains (10 to 50 micrometers) of high uranium concentration (100 to 3000 parts per million) were located in polished sections of eight potsherds from Cyprus, England, Greece, and Mexico by induced fission-track mapping. Most of the grains were identified as zircons or apatites by a microprobe attachment to a scanning electron microscope. The advantages in using such radioactive grains for thermoluminescence dating and alpha-recoil track dating are discussed.

Rate changes after unscheduled omission and presentation of reinforcement.

Changes in response rate similar to frustration effects were studied in a two-lever situation. Responding on one lever on a fixed-interval schedule produced access to water for 5 sec and an exteroceptive stimulus. In the presence of this stimulus, responding on another lever on a fixed-interval schedule produced access to water for 5 sec and terminated the stimulus. Occasional omission of a previously scheduled reinforcer after responding on the first lever resulted consistently in increases in rate on the second lever during the immediately succeeding interval. In another procedure, occasional presentation of a previously unscheduled reinforcer after responding on the first lever resulted consistently in decreases in rate on the second lever during the immediately succeeding interval. Changes occurred after the first omissions or presentations and were about the same in magnitude as the procedure continued over several sessions. Typically, an increase or decrease in rate was maintained throughout an entire 100-sec interval. Changes in rate on the second lever of approximately the same magnitude also occurred when rate on the first lever was near-zero under a schedule that differentially reinforced behavior other than lever pressing.

Concurrent schedules of primary and conditioned reinforcement in rats.

Rats responded on a fixed-interval schedule during which a 3-sec stimulus preceded each water reinforcement. The stimulus was then scheduled concurrently for responses on the same lever according to either a variable ratio. Although water reinforcement continued on a fixed-interval schedule, the pattern of responding became typical of a variable-interval or variable-ratio schedule. When the 3-sec stimulus was presented on a variable-interval or variable-ratio schedule, but was omitted on the fixed-interval schedule, the response rate decreased. When the stimulus occurred after the same time periods as those of the variable-interval schedule, but at least 7-sec after the last response, the rate decreased. The rate became higher when the fixed-interval schedule was discontinued and each presentation of the 3-sec stimulus was followed by water on a variable-interval schedule. When both water and the 3-sec stimulus were discontinued for a period of time, resulting in extinction of the lever response, and the 3-sec stimulus alone then presented on a variable-interval or variable-ratio schedule after lever responses, rate increased and then gradually decreased.

Pottery dating from thermoluminescence.

For pottery sherds from an arid region, the ratio of natural thermoluminescence to thermoluminescence induced by a standard dose of radiation corresponds closely to the independently assessed archeologic age. Difficulties in age determination, because of variations among sherds, are reduced by averaging results for samples from the same time period.