[Role of genetic factors in development of occupational obstructive lung disease].

The authors represent associative study of 180 patients having chronic obstructive lung disease 1-2 stages, who exposed at work to industrial pollutants (58.3% exposed to moderately fibrogenous dust and 41.7%--to a complex of aromatic organic solvents). Findings are increased (p < 0.05) concentration of IL-1beta in individuals exposed to chemicals, when compared to those exposed to dust at work. Relation was seen between transforming growth factor beta1 (rs1804470 of TGFB1 gene) and rs1828591 of HHIP gene with propensity to COLD formation. Genotype AA and AG demonstrated protective effect against the disease.

[State of hepatolienal circulation and liver functions in vibration disease under angioprotector treatment].

The authors demonstrate that angioprotector therapy with Telmisartan in vibration disease patients caused positive effects on hepatolienal circulation, liver microcirculation and clinical functional parameters.

[Hemodynamic and microcirculatory mechanisms underlying liver disorders in vibration diseases].

The article deals with hemodynamic and microcirculatory mechanisms underlying clinical and functional hepatic disorders - nonalcoholic steatosis and steatohepatitis. The authors defined various hemodynamics and microcirculation types in liver, that specify its disorders in vibration disease.

[Industrially mediated hemopathies and occupational diseases of blood].

The article covers criteria and classification of industrially mediated hematologic changes and occupational diseases caused by occupational factors hazardous for blood, mechanisms and clinical and laboratory peculiarities of hemopathies and toxic hemopoietic disorders. The authors present diagnostic parameters for the most prevalent pathologic hemopoietic conditions.

[Clinical and functional cardiac characteristics in iron-deficiency anemia]. / Kliniko-funktsional'naia kharakteristika serdtsa pri zhelezodefitsitnoi anemii.

AIM: To characterize clinically and electrocardiographically the condition of the heart in chronic iron deficient anemia (IDA), to study hemodynamic mechanisms of heart impairment for early detection of diastolic myocardial dysfunction in long-term course of sideropenia. MATERIAL AND METHODS: Clinical and ECG examinations were made in 400 IDA patients. Echocardiography and dopplerechocardiography were made in 95 and 27 patients, respectively. Patients with non-anemic myocardiodystrophy were withdrawn. Mean age of the patients was 35.4 +/- 3.8 years, mean Hb level--79.5 +/- 6.5 g/l, mean anemia duration 6.9 +/- 4.2 years. RESULTS: The severity of cardiac symptoms directly correlated with severity and duration of anemic sideropenic syndrome. 100% had heart complaints, 91.3% had mild chronic cardiac failure, 86.2% patients showed changes on the electrocardiogram. Diastolic insufficiency of both right and left ventricular myocardium was registered in almost all the examinees. CONCLUSION: Long-term anemia due to iron deficiency promotes metabolic and dystrophic alterations in the myocardium manifesting with diastolic dysfunction of both the ventricles prior to systolic failure. The study of cardiac diastolic function in IDA allows detection of early symptoms of cardiac failure which requires pharmacological correction.

[Quantitative and functional characteristics of T-lymphocytes and monocytes in lymphosarcoma patients at various stages of the neoplastic process]. / Kolichestvennaia i funktsional'naia kharakteristika T-limfotsitov i monotsitov u bol'nykh limfosarkomoi na raznykh stadiiakh opukholevogo protsessa.

IKO monoclonal antibodies were used to study peripheral blood mononuclear types in 92 patients with various histomorphological types of diffuse lymphosarcoma at various stages of tumorous process. Absolute counts of CD7 and CD5 cells (T cells) were found reducing as was CD4 cell (T helpers) level as the disease progressed. CD8 cell (T suppressors) count reliably increased only in the phase of lymphoblastic lymphosarcoma leukemic degeneration. A group of patients with stage IV lymphoblastic lymphosarcoma was detected with drastically increased counts of mononuclears carrying mature T cell markers. Clinical course of the disease in these patients was characterized by the highest malignancy degree and metastatic involvement of the central nervous system. Examination of peripheral blood monocyte/macrophage ratio in the same patient population (n = 26) revealed reduced Fc receptor expression, EA phagocytosis, and increased levels of circulating immune complexes, these shifts augmenting with the tumor progress. The results may be valuable for prediction of lymphosarcoma course and for immunocorrection.

[Structure and function of erythrocytes in lymphomas]. / Struktura i funktsiia éritrotsitov pri limfomakh.

Significant changes have been recorded in the concentration of sulfhydryl groups, histidine, lipoproteins, catalase activity, saponin resistance, and kinetics of chemiluminescent responses of red blood cells in lymphoma patients. Lymphosarcoma is characterized by changes in the structure and function of red blood cells at the early stage of the process, whereas in lymphogranulomatosis changes are observed with the disease progressing, when pronounced signs of tumor intoxication are noted and anemia is present. In lymphosarcoma patients an increase of peripheral blood mononuclears is recorded which expresses the erythroid differentiating antigens with the use of monoclonal antibodies against glycophorin A (ZAE-3) and human erythroblast antigen AG-EB (HAE-9). In lymphogranulomatosis patients it was not detected.

[The expression of lymphopoietic differentiation antigens on the membrane of the peripheral blood mononuclear cells in lymphosarcoma tumor progression]. / Izuchenie ékspressii differentsirovochnykh antigenov limfopoéza na membrane mononuklearov perifericheskoi krovi pri opukholevoi progressii limfosarkom.

Monoclonal antibodies were used in the indirect immunofluorescence test to assay the antigenic features of lymphoid cells in patients with lymphosarcoma. Some patients with progression of lymphoblastic lymphoma showed an increased content of T lymphocyte expressing early activation antigens, antigens of early hemopoietic progenitors, and CALLA-antigens.

[A method for the early detection and treatment of patients with iron deficiency states]. / Metodika rannego vyiavleniia i lecheniia patsientov s zhelezodefitsitnymi sostoianiiami.

In order to optimize the identification of persons with iron deficiency during mass prophylactic screenings, a diagnostic algorithm using a unified questionnaire was proposed and introduced into medical practice. During 1985-1987, a total of 3655 women aged 18 to 54 years belonging to different occupational groups filled in questionnaires at an industrial enterprise of Novosibirsk. The women were distributed into several groups: group I was made up of normal persons, group II of persons at risk, group III of persons with latent iron deficiency, group IV of persons with iron deficiency anemia, and group V of patients with continuously relapsing iron deficiency anemia refractory to therapy. Taking into account the groups indicated, the diagnostic and the treatment and prophylactic measures have been elaborated.