1.
Steroids
; 151: 108446, 2019 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31302114
RESUMO
In this study, the biotransformation of progesterone (1) and testosterone enanthate (5) using the whole cells of Circinella muscae was investigated for the first time. Microbial transformation of 1 with C. muscae afforded three known metabolites including 9α-hydroxyprogesterone (2), 14α-hydroxyprogesterone (3) and 6ß,14α dihydroxyprogesterone (4) after 6â¯days of incubation at 26⯰C. The biotransformation of 5 with C. muscae yielded a new metabolite; 8ß,14α-dihydroxytestosterone (8), in addition to two known metabolites; 6ß-hydroxytestosterone (6), and 9α-hydroxytestosterone (7). The structure of the metabolites were established on the basis of spectroscopic data.