RESUMO
BACKGROUND: Thrombosis resulting from heparin-induced thrombocytopenia (HIT) occurs in about 2% of patients without a significant decrease in platelet counts. We report on such a near fatal thrombotic event caused by coronary intervention. CASE PRESENTATION: A supposedly "completely healthy" 53-year-old patient was admitted to hospital with covered rupture of an aneurysm of the Aorta descendens. He was successfully operated on and underwent coronary angiography due to NSTEMI six days later. Immediately after intervention of a 90% RCX stenosis he developed ventricular flutter, was defibrillated, and re-angiography showed partial occlusion of the RCX stent. Lots of white thrombi could be retrieved by aspiration catheter and gave reason for a HIT without thrombocytopenia. The detection of platelet factor 4/heparin complex antibodies by immunoassay supported and the subsequent Heparin Induced Platelet Activation Assay proved this diagnosis. CONCLUSIONS: The clinical event of an acute stent thrombosis should alarm the interventional team to the diagnosis of HIT even with a normal platelet count.
Assuntos
Aneurisma Roto/cirurgia , Anticoagulantes/efeitos adversos , Aneurisma da Aorta Torácica/cirurgia , Implante de Prótese Vascular , Aneurisma Coronário/terapia , Estenose Coronária/terapia , Trombose Coronária/etiologia , Heparina/efeitos adversos , Intervenção Coronária Percutânea/efeitos adversos , Trombocitopenia/induzido quimicamente , Aneurisma Roto/diagnóstico por imagem , Anticoagulantes/administração & dosagem , Anticoagulantes/imunologia , Aneurisma da Aorta Torácica/diagnóstico por imagem , Autoanticorpos/sangue , Aneurisma Coronário/complicações , Aneurisma Coronário/diagnóstico por imagem , Estenose Coronária/diagnóstico por imagem , Estenose Coronária/etiologia , Trombose Coronária/diagnóstico por imagem , Trombose Coronária/terapia , Stents Farmacológicos , Heparina/administração & dosagem , Heparina/imunologia , Humanos , Pessoa de Meia-Idade , Intervenção Coronária Percutânea/instrumentação , Fator Plaquetário 4/imunologia , Fatores de Risco , Trombectomia , Trombocitopenia/sangue , Trombocitopenia/diagnóstico , Trombocitopenia/imunologia , Resultado do TratamentoRESUMO
Pseudocholinesterase or butyrylcholinesterase (BChE) inactivates the relaxant drugs mivacurium and suxamethonium. A deficiency in plasma activity of this enzyme may result in prolonged muscular paralysis and subsequently the need for an extended duration of mechanical ventilation. We report the case of a 65-year-old patient who was diagnosed with butyrylcholinesterase deficiency for the first time during elective surgery. Neuromuscular monitoring constitutes a central diagnostic asset in ensuring patient safety.