RESUMO
To study the association between disease progression and some clinical features and biochemical spinal fluid parameters, we have examined 209 patients with remitting type of multiple sclerosis. The more rapid progression of multiple sclerosis was associated with male sex, a history of brain concussion, a short first remission, late disease onset, movement disorders at onset of the disease and the high level of platelet endothelial cell adhesion molecule 1 (sPECAM-1) in the spinal fluid.
Assuntos
Esclerose Múltipla Recidivante-Remitente/diagnóstico , Esclerose Múltipla Recidivante-Remitente/fisiopatologia , Adulto , Traumatismos Craniocerebrais/complicações , Progressão da Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla Recidivante-Remitente/líquido cefalorraquidiano , Molécula-1 de Adesão Celular Endotelial a Plaquetas/líquido cefalorraquidiano , Fatores SexuaisRESUMO
The "case-control" research in Russian Altai territory population has proved that DR15 and DR3 as well as the combination of female sex and alleles A of TNFα of rs1800629 locus are associated with high risk of multiple sclerosis. The relationship between disease and CD40 polymorphism (rs6074022) was not found.
Assuntos
Antígenos HLA-DR/genética , Esclerose Múltipla/epidemiologia , Esclerose Múltipla/genética , Fator de Necrose Tumoral alfa/genética , Adulto , Alelos , Antígenos CD40/genética , Feminino , Cadeias HLA-DRB1 , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo Genético , Fatores de Risco , Sibéria/epidemiologiaRESUMO
Levels of adhesion molecules were measured in 24 patients with multiple sclerosis during the 3-years prospective study. The high level of adhesion molecules sPECAM in the cerebrospinal fluid was associated with the appearance of new foci according to the magnetic resonance imaging data as well as with quick disability.
Assuntos
Esclerose Múltipla/líquido cefalorraquidiano , Esclerose Múltipla/diagnóstico , Molécula-1 de Adesão Celular Endotelial a Plaquetas/líquido cefalorraquidiano , Molécula 1 de Adesão de Célula Vascular/líquido cefalorraquidiano , Adulto , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Estudos ProspectivosRESUMO
Chronic inflammatory diseases of the prostate are accompanied by the accumulation of active oxygen forms and the activation of biopolymer peroxidation. The increased concentration of thiobarbituric acid reactive substances and the decreased activity of antioxidant enzymes in the ejaculate of patients with chronic abacterial prostatitis are attended by spermatozoon defects. It is suggested that correction of the metabolism of active oxygen forms in patients with chronic abacterial prostatitis has a positive effect.
Assuntos
Antioxidantes/metabolismo , Prostatite/metabolismo , Prostatite/patologia , Espécies Reativas de Oxigênio/metabolismo , Sêmen/metabolismo , Espermatozoides/patologia , Adulto , Estudos de Casos e Controles , Ejaculação , Humanos , Peroxidação de Lipídeos , Masculino , Pessoa de Meia-Idade , Prostatite/fisiopatologia , Sêmen/enzimologia , Motilidade dos Espermatozoides , Espermatozoides/enzimologia , Espermatozoides/metabolismo , Adulto JovemRESUMO
A total of 28 males aged 20-46 years with chronic abacterial prostatitis (CAP) were divided into two groups. Group 1 patients received standard therapy (prostatotropic, vitamin, antioxidant); group 2 received the same standard treatment plus peloid therapy including silver-containing clay "Bekhtemirskaya". Eleven males with documented fertility (sperm donors) comprised a control group. The participants of the trial were examined for ejaculate indices, activity of the antioxidant system, ion composition of ejaculate, prostatic microcirculation before the treatment, on treatment day 14 and 90. The examination revealed the following disorders in CAP patients: low activity of anti-oxidant enzymes, abnormal static microcirculation, low content of normal spermatozoa in ejaculate. Complex rehabilitation of the patients of both groups improved prostatic microcirculation, raised activity of the antioxidant system resulting in better mobility and viability of spermatozoa. In group 2 the results were better showing the efficacy of local peloid therapy.
