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1.
Death Stud ; 47(7): 784-791, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36240232

RESUMO

To investigate the mediating role of rumination in the association between childhood maltreatment and suicidal behavior, and the moderating role of regulatory emotional self-efficacy, university students (N = 1,458) from 5 universities in China completed questionnaires in classrooms. Path analyses showed emotional maltreatment had the greatest positive association with suicidal behavior and rumination compared with other types of childhood maltreatment. Rumination partly mediated the relationship between childhood maltreatment and suicidal behavior. High regulatory emotional self-efficacy moderated the relation between ruminating childhood maltreatment and suicidal behavior.


Assuntos
Maus-Tratos Infantis , Ideação Suicida , Criança , Humanos , Autoeficácia , Emoções , Universidades
2.
Neuropsychol Rehabil ; 33(9): 1564-1581, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-36059235

RESUMO

OBJECTIVE: The purpose of this study was to explore the prevalence, severity, and factors associated with multidimensional fatigue in Chinese patients with newly diagnosed meningiomas. METHODS: This cross-sectional study included 120 Chinese meningioma patients. Data were collected before surgery, including demographic, clinical, psychological, and sleep characteristics, as well as fatigue scores based on completion of the Multidimensional Fatigue Inventory (MFI-20). Mann-Whitney U tests, Kruskal-Wallis H tests, Spearman correlation and multiple linear regression were used to analyze the data. RESULTS: The results showed there was a high prevalence of severe fatigue for each dimension: general fatigue (33.3%), physical fatigue (27.5%), reduced activity (28.3%), reduced motivation (12.5%), mental fatigue (11.7%), and total fatigue (23.3%). Headache and anxiety were found to be associated with general fatigue. Depression was related with physical fatigue. The Karnofsky Performance Status (KPS) score and depression were associated with reduced activity. Depression and the Epworth Sleepiness Scale (ESS) score were correlated with reduced motivation, while the KPS score and anxiety were associated with mental fatigue. Importantly, comorbidity, the KPS score, headache, depression, sleep disturbances, and the ESS score remained strong correlates of total fatigue. CONCLUSIONS: Our findings indicate that newly diagnosed meningioma patients are affected by multidimensional fatigue. For patients with risk factors of fatigue, targeted interventions are advised to decrease fatigue and improve HRQoL.


Assuntos
Neoplasias Meníngeas , Meningioma , Humanos , Meningioma/complicações , Meningioma/epidemiologia , Prevalência , Estudos Transversais , População do Leste Asiático , Qualidade de Vida , Neoplasias Meníngeas/complicações , Neoplasias Meníngeas/epidemiologia , Cefaleia , Fadiga Mental , Depressão/diagnóstico , Depressão/epidemiologia , Depressão/etiologia
3.
Asia Pac J Clin Nutr ; 31(4): 674-682, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36576285

RESUMO

BACKGROUND AND OBJECTIVES: Nutritional status is presumed essential for healthy longevity. The city of Rugao in Jiangsu province recognized as a long-lived area on the coastal plain of China, with a higher proportion of centenarians than Chinese elsewhere or in the world at large. The nutritional status and related factors of centenarians in Rugao, along with muscle mass and activities of daily living (ADL) have been documented with a view to improved nutritional and health approaches to healthy ageing. METHODS AND STUDY DESIGN: A cross-sectional study was conducted in Rugao from April 2020 to December 2020. 116 local centenarians agreed to participate in the study. Nutritional status was evaluated by the Mini Nutritional Assessment Short Form (MNA-SF), and ADL was assessed by the Barthel Index (BI). Anthropometric data (e.g., calf circumference) and body composition data (e.g., skeletal muscle mass) were collected as muscle mass variables. RESULTS: The age of centenarians ranged from 100 to 109 years. According to MNA-SF assessment, only 6 (5.2%) of 116 centenarians were malnourished, and 57 (49.1%) were at risk of malnutrition. Binary logistic regression results indicated that prealbumin, albumin, bean product consumption, and current exercise status were independent determinants of centenarians' nutritional status. Centenarians with poor nutritional status tended to have worse muscle mass and BI scores. CONCLUSIONS: Nearly half of the centenarians maintained normal nutritional status, insofar as muscle mass condition and function were concerned. Frequent bean product consumption and routine exercise were conducive to healthier centenarian nutritional status.


Assuntos
Desnutrição , Estado Nutricional , Idoso de 80 Anos ou mais , Idoso , Humanos , Atividades Cotidianas , Centenários , Estudos Transversais , Avaliação Geriátrica/métodos , Desnutrição/complicações , Avaliação Nutricional , Músculos
4.
Adv Sci (Weinh) ; 9(36): e2204849, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-36354175

RESUMO

Centenarians, who show mild infections and low incidence of tumors, are the optimal model to investigate healthy aging. However, longevity related immune characteristics has not been fully revealed largely due to lack of appropriate controls. In this study, single-cell transcriptomic analysis of peripheral blood mononuclear cells (PBMCs) derived from seven centenarians (CEN), six centenarians' offspring (CO), and nine offspring spouses or neighbors (Control, age-matched to CO) are performed to investigate the shared immune features between CEN and CO. The results indicate that among all 12 T cell clusters, the cytotoxic-phenotype-clusters (CPC) and the naïve-phenotype-clusters (NPC) significantly change between CEN and ontrol. Compared to Control, both CEN and CO are characterized by depleted NPC and increased CPC, which is dominated by CD8+ T cells. Furthermore, CPC from CEN and CO share enhanced signaling pathways and transcriptional factors associated with immune response, and possesse similar T-cell-receptor features, such as high clonal expansion. Interestingly, rather than a significant increase in GZMK+ CD8 cells during aging, centenarians show accumulation of GZMB+ and CMC1+ CD8 T cells. Collectively, this study unveils an immune remodeling pattern reflected by both quantitative increase and functional reinforcement of cytotoxic T cells which are essential for healthy aging.


Assuntos
Centenários , Leucócitos Mononucleares , Humanos , Transcriptoma/genética , Linfócitos T CD8-Positivos , Longevidade/genética
5.
Ann Palliat Med ; 11(4): 1278-1289, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34775772

RESUMO

BACKGROUND: Evidence suggests that poor mental health (MH) is a risk factor for the health of older adults. Dietary diversity is considered to be related to healthy aging. However, the relationship between diet and MH is still unclear. Therefore, the purpose of this study was to investigate the relationship between dietary diversity score (DDS) and anxiety and depression among centenarians and their offspring and spouses. METHODS: Our study was observational and cross-sectional. The Generalized Anxiety Disorder Scale (GAD-7), the 15-item version of the Geriatric Depression Scale (GDS-15), and the dietary frequency questionnaire were used to measure the status of anxiety, depression, and dietary diversity. Data were analyzed by Student's t-test, χ2 test, Mann-Whitney U test, correlational analysis, and univariate or multivariate logistic regression. RESULTS: Among the 288 older adults, 12.8% reported symptoms of depression, and 8.7% reported anxiety. People with a lower dietary diversity had higher rates of anxiety and depression. After controlling for age, place of residence, economic status, alcohol drinking, and physical activity, a lower DDS was found to be a risk factor for depressive symptoms [odds ratio (OR): 2.237; 95% confidence interval (CI): 1.009-4.959; P=0.048]. DDS was negatively correlated with depression score in older adults (r=-0.224; P<0.001), especially offspring and their spouses (r=-0.275; P<0.001). However, no significant relationship was observed between DDS and anxiety. In addition, eating legumes (OR: 0.415; 95% CI: 0.188-0.920; P=0.030) and nuts (OR: 0.255; 95% CI: 0.116-0.561; P=0.001) at least once a week can act as protective factors for depression. Eating nuts (OR: 0.405; 95% CI: 0.168-0.978; P=0.044) and meat (OR: 0.396, 95% CI: 0.161-0.975; P=0.044) at least once a week can act as protective factors for anxiety. CONCLUSIONS: These results suggest an association between low dietary diversity and a higher incidence of mental disorders. Further, the possibility of reverse causality cannot be ruled out. It is necessary to conduct further prospective studies.


Assuntos
Depressão , Dieta , Idoso , Idoso de 80 Anos ou mais , Ansiedade/epidemiologia , China/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Depressão/etiologia , Humanos , Estudos Prospectivos , Fatores de Proteção
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