RESUMO
Experiments on animals with Lewis lung carcinoma and Ehrlich tumor showed that licorice (glycyrrhiza) extract and glyciram prepared from this plant improved the antitumor effect of cyclophosphamide. Glyciram reduced the toxic effect of the cytostatic on peripheral blood leukocytes. Licorice extract inhibited the growth of Ehrlich tumor and development of metastases in mice with Lewis lung carcinoma. Glyciram administered to mice after removal of Lewis lung carcinoma produced an antimetastatic effect and prevented relapses.
Assuntos
Antineoplásicos/uso terapêutico , Carcinoma de Ehrlich/tratamento farmacológico , Carcinoma de Ehrlich/cirurgia , Carcinoma Pulmonar de Lewis/tratamento farmacológico , Carcinoma Pulmonar de Lewis/cirurgia , Glycyrrhiza/química , Transplante de Neoplasias , Animais , Carcinoma de Ehrlich/patologia , Carcinoma Pulmonar de Lewis/patologia , Feminino , Ácido Glicirretínico/uso terapêutico , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA , Metástase Neoplásica/tratamento farmacológico , Extratos Vegetais/uso terapêuticoRESUMO
AIM: To study alterations in lipid peroxidation, antioxidant status of the lungs and immune state of the organism in some chronic diseases of the skin and potentialities of their correction with preparation produced of Ural licorice root. MATERIAL AND METHODS: Lipid peroxidation, antioxidant system parameters were examined in condensates of the expired air of 54 healthy subjects and 60 patients with chronic skin diseases. Immune status was studied in blood samples. The patients were given the drug made of Ural licorice root. RESULTS: The licorice-based drug normalized antioxidant defense and immune status. CONCLUSION: It was found possible to correct pulmonary and immune statuses of patients with some chronic skin diseases in polluted environment with a licorice drug.