[The effect of natural polyphenol complex of red grape wine on L-arginine/NO system in peripheral blood of rats under low doses of ionizing radiation].

The total activity of NO-synthase and content of stable metabolitic products of nitric oxide in the peripheral blood of rats under low doses of ionizing radiation and administration of natural polyphenol complex of grape was investigated. It was found that natural polyphenol compounds of grapes have the ability to correct radioinduced changes in L-arginine/NO system. It was noted that the action of X-radiation increased activity of NO-synthase in the peripheral blood of rats. However, the consumption of natural polyphenol complex of grape led to a decrease of this index to control values. An increase in NOS activity under irradiation leads to the increase of NO stable metabolites content, which is reflected in the accumulation of nitrite- and nitrate-anions in the peripheral blood of rats. The consumption of preparation of polyphenol complex this index decreased in the early period of the experiment, and on the third day after exposure, the total content of NO stable metabolites is slightly higher compared to the indices of control animals. Thus, the ability of natural polyphenol complex to cause attenuation of oxidative-nitrative stress caused by ionizing radiation was investigated experimentally.

[Kolsky register of births as an instrument of epidemiologic studies of female reproductive health].

The authors evaluate possible use of Monchegorsk retrospective birth database for demographic and epidemiologic studies of various female reproductive health parameters, newborn health parameters, as well as their connections with occupational and other environmental factors.

[Clinical and physiological methods of examination for cardiac and respiratory systems in aluminium production workers of Kolsky North]. / Kliniko-fiziologicheskie metody issledovaniia kardio-respiratornoi sistemy u rabochikh aliuminievogo proizvodstva na Kol'skom Severe.

The authors presented clinical and physiologic studies of cardiac and respiratory systems and peripheral circulation among workers having various professions at aluminium production in Kolsky North. Multiple functional study methods were used including tachooscillography, electrocardiography, rheovasography, rheoencephalography, thermovision. The results enabled to specify duration and character of health disorders caused by occupational environment.