RESUMO
In this study, we propose new concepts of Active Potential Energy Well, Specificity and Non-Specificity of the wells. We perform these concepts to establish a 3-D physical model and to elucidate how a complete functional ribosome traps an aminoacyl tRNA, and how it moves along the mRNA template in the elongation of protein synthesis. In our model, we first introduce concepts of reduced mass and relative coordinates of a two objects system. Then we simplify a ribosome movement along mRNA in protein synthesis. We also introduce concepts of active objects and active controls in this study. Our model is based on quantum mechanics, thermal dynamics and the published biochemical data.
Assuntos
Modelos Químicos , Biossíntese de Proteínas , RNA Mensageiro/metabolismo , Aminoacil-RNA de Transferência/metabolismo , Ribossomos/fisiologia , Movimento Celular/fisiologia , Simulação por Computador , Transferência de Energia , Substâncias Macromoleculares , Modelos Moleculares , Movimento (Física) , Elongação Traducional da Cadeia Peptídica , Conformação Proteica , Proteínas/química , Teoria Quântica , RNA Mensageiro/química , Aminoacil-RNA de Transferência/química , Ribossomos/química , Relação Estrutura-AtividadeRESUMO
In this study, we propose new concepts of Active Potential Energy Well, Specificity and Non-Specificity of the wells. We perform these concepts to establish a 3-D physical model and to elucidate how a complete functional DNA polymerase traps a deoxyribonucleoside triphosphate, and how it moves along a DNA template strand in the elongation of a DNA replication. In our model, we first introduce concepts of reduced mass and relative coordinates of a two objects system. Then we simplify a DNA polymerase movement in DNA replication. We also introduce concepts of active objects and active controls in this study. Our model is based on quantum mechanics, thermal dynamics and published biochemical data.