Assuntos
Anormalidades Múltiplas/diagnóstico por imagem , Intestinos/anormalidades , Intestinos/diagnóstico por imagem , Divertículo Ileal/complicações , Divertículo Ileal/diagnóstico por imagem , Pertecnetato Tc 99m de Sódio , Adolescente , Humanos , Masculino , Cintilografia , Compostos RadiofarmacêuticosAssuntos
Fígado/metabolismo , Compostos Radiofarmacêuticos/farmacocinética , Baço/metabolismo , Medronato de Tecnécio Tc 99m/farmacocinética , Macroglobulinemia de Waldenstrom/diagnóstico por imagem , Feminino , Humanos , Pessoa de Meia-Idade , Paraproteínas/análise , Tomografia por Emissão de Pósitrons , Tomografia Computadorizada por Raios X , Macroglobulinemia de Waldenstrom/metabolismo , Imagem Corporal TotalAssuntos
Doenças das Artérias Carótidas/diagnóstico por imagem , Doenças das Artérias Carótidas/metabolismo , Doença de Moyamoya/diagnóstico por imagem , Doença de Moyamoya/metabolismo , Medronato de Tecnécio Tc 99m/metabolismo , Adolescente , Doenças das Artérias Carótidas/complicações , Feminino , Humanos , Doença de Moyamoya/complicações , CintilografiaRESUMO
A 64-year-old woman presented with a painless breast mass. Tc-99m methoxyisobutylisonitrile scintigraphy of both breasts showed a local area of abnormal uptake in the left breast in 5 min and 2 h. A skeletal scan showed very intense concentration of activity in the primary breast tumor in the left breast. A left mastectomy and an axillary dissection were performed. The predominant histologic type of the mass was an osteosarcoma, and the diagnosis of a primary osteogenic sarcoma of the breast was made. Primary osteogenic sarcoma of the breast is rare and represents less than 1% of all primary breast malignancies.
Assuntos
Neoplasias da Mama/diagnóstico por imagem , Osteossarcoma/diagnóstico por imagem , Medronato de Tecnécio Tc 99m , Tecnécio Tc 99m Sestamibi , Feminino , Humanos , Pessoa de Meia-Idade , Cintilografia , Compostos Radiofarmacêuticos , Doenças Raras/diagnóstico por imagemRESUMO
OBJECTIVE: To evaluate the performance of 18F-FDG three-head tomography with coincidence imaging and serum tumor marker assays in identifying lung lesions in 104 patients with abnormal findings on chest X-ray or computer tomography. METHODS: A prospective evaluation of 18F-FDG coincidence imaging and the measurement of 3 serum markers for lung cancer ( carcinoembryonic antigen, CYFRA21-1 and neuron specific enolase) were performed within one week in 104 inpatients with suspected lung malignancy. All images were analyzed visually. It was considered positive for malignancy if the 18F-FDG uptake was increased relative to that in the adjacent lung tissue, and was focal. The serum tumor marker test was considered positive for malignancy if the serum level of at least one marker was elevated. RESULTS: 66 patients were proven to have lung cancer by pathology, and 38 patients had benign lung diseases. The sensitivity, specificity, accuracy of 18F-FDG coincidence imaging and serum tumor markers in assessing lung cancers were 80. 0% , 77. 2% , 77. 9% and 56. 0% , 60. 9%, 64. 4% , respectively. 18F-FDG coincidence images in assessing lung lesions showed significantly higher sensitivity, specificity and accuracy than serum tumor markers. Four patients with lung cancer had negative findings on 18F-FDG coincidence images but showed positive serum markers. CONCLUSION: 18F-FDG coincidence imaging is a powerful tool for evaluating patients with lung lesions suggestive of malignancy. Although the determination of serum marker levels is less accurate than 18F-FDG coincidence imaging, the combination of a positive 18F-FDG coincidence result and positive tumor markers may be helpful in improving the diagnosis of lung cancers.
Assuntos
Biomarcadores Tumorais/sangue , Carcinoma de Células Escamosas/diagnóstico , Fluordesoxiglucose F18 , Neoplasias Pulmonares/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Antígenos de Neoplasias/sangue , Antígeno Carcinoembrionário/sangue , Carcinoma de Células Pequenas/sangue , Carcinoma de Células Pequenas/diagnóstico , Carcinoma de Células Pequenas/diagnóstico por imagem , Carcinoma de Células Escamosas/sangue , Carcinoma de Células Escamosas/diagnóstico por imagem , Feminino , Humanos , Queratina-19 , Queratinas/sangue , Neoplasias Pulmonares/sangue , Neoplasias Pulmonares/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Fosfopiruvato Hidratase/sangue , Granuloma de Células Plasmáticas Pulmonar/sangue , Granuloma de Células Plasmáticas Pulmonar/diagnóstico , Granuloma de Células Plasmáticas Pulmonar/diagnóstico por imagem , Tomografia por Emissão de Pósitrons , Estudos Prospectivos , Compostos Radiofarmacêuticos , Sensibilidade e Especificidade , Tuberculose Pulmonar/sangue , Tuberculose Pulmonar/diagnóstico , Tuberculose Pulmonar/diagnóstico por imagemRESUMO
OBJECTIVE: To evaluate the accuracy of [18F] fluorodeoxyglucose (FDG) triple-head coincidence imaging in the setting of suspected lung cancer. METHODS: 109 patients with suspected lung cancer were enrolled in the present study. According to the diameter of the lesion (> 1.5 cm, = 1.5 cm), patients were divided into two groups. The sensitivity, specificity and accuracy of the results were calculated and the results were compared with pathological results. RESULTS: Of the total of 109 patients, 86 cases were confirmed as lung cancer whereas 23 cases were benign by pathological study. The sensitivity, specificity and accuracy of FDG imaging were 95% (82/86), 74% (17/23) and 91% (99/109), respectively. For the group of lesion diameter > 1.5 cm, the sensitivity, specificity and accuracy were 98% (81/83)), 63% (10/16) and 92% (91/99), respectively. While for the group of lesion diameter = 1.5 cm, the results were 1/3, 7/7, and 8/10, respectively. The difference between the two groups was significant (P = 0.005). CONCLUSIONS: The technique of [18F] FDG imaging is an useful method for routine evaluation of patients with suspected lung cancer. The sensitivity of detection is related to lesion size, if lesions = 1.5 cm in diameter the results of FDG imaging should be carefully analyzed.