[Biochemical changes of red blood cells in children with cerebral palsy and other organic brain disorders].

One hundred and twenty-five children with cerebral palsy (n = 108) and organic CNS lesions (n = 17) have been studied. A control group included 30 children without any neurological lesions. Lipids and phospholipids spectra, Ca, Mg- and Na, K-ATPases, intensity of red blood cells lipid peroxidation and erythrocyte free magnesium content have been determined. Children with cerebral palsy had a higher percentage of cholesterol ethers and final products of lipid peroxidation in red blood cells--Shiff bases and a decrease of intraerythrocytic free magnesium. Patients with atonic-astatic syndrome were characterized by a sharp increase of Na, K-ATPase activity accompanied by increased content of such phospholipids as cardiolipin and phosphatide acid as well as Shiff bases. In patients with organic CNS lesions, Shiff bases content was similar to that in the control group, intracellular magnesium also did not differ significantly from the controls, but cardiolipin, phosphatide acid, cholesterol ethers and triglycerol concentrations were reduced. All the patients with neurological disorders had an increased percentage of phosphatidilcholin in red blood cells.

[Study of vertical transmission of coxsackie group enteroviruses in the etiology of congenital immunodeficiencies]. / Znachenie vertikal'noi peredachi énterovirusov gruppy koksaki v étiologii vrozhdennykh immunodefitsitnykh sostoianii.

Morphological and virological studies were carried out in 26 cases of perinatal and neonatal deaths in a group at a high risk of vertical transmission of Coxsackie viruses. Antigens of Coxsackie viruses A and B were identified in 73.1% of autopsy materials, including the thymus. Adenovirus and rubella virus antigens were detected much more rarely: in 26.9 and 30.8% of cases. The incidence of Coxsackie viruses was minimal (50%) in cases when thymic abnormalities were confined to the initial signs of preterm involution and reliably increased if the involution was more expressed in the presence of underdeveloped thymus, reaching 100% in cases with the terminal stage of preterm involution in the presence of marked immaturity. The data confirm the hypothesis about the principal role of Coxsackie virus in the etiology of secondary congenital immunodeficiencies detected in children at a high risk of vertical transmission of these viruses.

[An experimental model of the vertical transmission of the Coxsackie-group enteroviruses and its use in developing methods to prevent congenital coxsackievirus infection]. / Eksperimental'naia model' vertikal'noi peredachi énterovirusov gruppy Koksaki i ee ispol'zovanie pri razrabotke metodov profilaktiki vrozhdennoi Koksaki-virusnoi infektsii.

An experimental model of vertical transmission of Coxsackie group enteroviruses was developed in BALB/c mice the first generation of which was infected with Coxsackie A18 virus in the neonatal period. Persistence of the virus was demonstrated in all females of the first generation tested and in 90.9% to 100% of the animals of the next two generations. Cytochemical analysis of the enzyme status of lymphocytes revealed reliable relationship between the depression of energetic metabolism enzymes and the activity of virus amplification in the animals under study. The correction of aerobic respiration in pregnant females by administration of a complex of energy metabolism substrates and cofactors was accompanied by a significant reduction of the virus infection activity in the females and their offsprings as well as by prevention of transplacental infection in some litters. The experimental model of vertical transmission of enteroviruses is proposed for use in the development of methods for prevention of congenital Coxsackie virus infection. The authors express their deep gratitude to the sponsor of the publication--NOVRUZ Co., Turkmenistan.