[Chemotherapeutic effectiveness of gentamycin, tobramycin and sisomycin in Pseudomonas aeruginosa pyelonephritis in rats compared with dioxidine]. / Izuchenie khimioterapevticheskoi éffektivnosti gentamitsina, tobramitsina i sizomitsina pri sinegnoinom pielonefrite u krys v sravnenii s dioksidinom.

The chemotherapeutic efficacy of gentamicin, tobramycin, sisomicin and dioxydin was studied and compared in rats with hematogenic obturation P. aeruginosa pyelonephritis. The drugs were injected intramuscularly in doses of 5, 8, 8 and 50 mg/kg, respectively for 7 days a day after infection. It was shown that on prolongation of the period of the treatment estimation from 24 hours to 7 days after discontinuation of the drug use a significant decrease was observed in the therapeutic efficacy of dioxydin, gentamicin and especially tobramycin. As for sisomicin, the decrease was insignificant. Dioxydin and gentamicin had a similar therapeutic effect at the early and late periods of their estimation after discontinuation of the treatment. They were inferior to tobramycin with respect to the early results and superior to it with respect to the late results. The chemotherapeutic efficacy of sisomycin in both the cases was higher than that of tobramycin, gentamicin and dioxydin.

Influence of products of the vital activity of helminths on the corticosterone content in the adrenals and blood.

The content of corticosterone in the adrenals and blood plasma, as well as the weight of the adrenals and their histology, were investigated in 77 inbred rats (38 animals of the August line and 39 animals of the Wistar line). It was shown that after products of ascarid metabolism were administered to the experimental rats, the corticosterone content in the adrenals and blood plasma changed substantially. Despite the equal doses of the agent administered, statistically significant differences between lines were detected in the corticosterone indices in the blood plasma of the experimental rats, and they were also present in the control (healthy) animals. In the latter, no differences between lines were established in the corticosterone content in the adrenals, although in the experimental rats these differences arose at many periods of observation. It is concluded that the level of corticosterone content of the blood in the initial normal state, as well as the degree of its deviations from the initial norm, are determined (with equal conditions with respect to paratypic factors) by the genetic constitution (genotype) of the organism.

[Method of morphometric study of the kidneys]. / K metodike morfometricheskogo issledovaniia pochek

The authors describe two measuring and counting method suitable for the morphometric and histometric analysis of the main structures of the kidneys: the volume of the cortical substance and medulla, the pelvis and vessels; the quantity, the size and the volume of glomeruli.