Evaluation of new chlorhexidine- and cetylpyridinium chloride-based mouthrinse formulations adjunctive to scaling and root planing: pilot study.

OBJECTIVE: To compare the effect of two newly formulated chlorhexidine (CHX) and cetylpyridinium chloride (CPC) mouthrinses after scaling and root planing (SRP) in terms of clinical, microbiological, patient-based variables and adverse events, with a positive control with the same active components, already marketed and tested. METHODS: A pilot, randomized clinical trial, double-blind, parallel design with 1-month follow-up was conducted. Chronic periodontitis patients requiring non-surgical periodontal therapy were enrolled and randomly assigned to: (i) SRP and test-1 (new reformulation: 0.12% CHX and 0.05% CPC); (ii) SRP and test-2 (new formulation: 0.03% CHX and 0.05% CPC); or (iii) SRP and positive control (commercial product: 0.12% CHX and 0.05% CPC). All variables were evaluated at baseline and 1 month after SRP. Quantitative variables were compared by means of anova or Kruskal-Wallis test and qualitative variables by chi-square or McNemar tests. RESULTS: Thirty patients (10 per group) were included. After 1 month, there were significant differences among groups in plaque levels (P = 0.016) as test-1 showed less sites with plaque than test-2 (31.15% [standard error-SE 2.21%] versus 49.39% [SE 4.60%), respectively). No significant differences were found for global patient perception of the product or in adverse effects. Test groups showed better results in levels and proportions (P = 0.022) of Capnocytophaga spp. CONCLUSIONS: Within the limitations of this pilot study, it can be concluded that the newly formulated 0.12% CHX and 0.05% CPC mouthrinse showed larger plaque level reductions, without showing more adverse effects, when compared to the other two mouthrinses, after SRP.

Tratamiento no quirúrgico en el tratamiento de periimplantitis. Revisión narrativa / Non-surgical therapy in treating peri-implantitis

Existen una gran variedad de protocolos terapéuticos a la hora de tratar la periimplantitis, desde tratamientos desinfectantes, desbridación mecánica hasta procedimientos quirúrgicos. Estudios han demostrado discordancias en sus resultados con respecto a cual es el método ideal para tratar una periimplantitis. El uso de instrumentos de desbridamiento mecánico, el método láser, antibioterapia, enfoques quirúrgicos ya sean resectivas o regenerativas muestran resultados heterogéneos. Al presente, no existe suficiente evidencia científica para poder valer un tratamiento específico no quirúrgico a la hora de enfrentarnos a una periimplantitis. El objetivo de esta revisión narrativa será analizar la literatura actual sobre el tratamiento no quirúrgico de la periimplantitis y sus indicaciones y eficacia como tratamiento. No se ha visto que tratando una la lesión periimplantaria mediante un enfoque terapéutico no quirúrgico haya dado resultados efectivos y el uso de antisépticos locales como auxiliar sólo ha mostrado efectos limitados sobre las variables clínicas y microbiológicas. Se necesitan más estudios randomizados y controlados con resultados a largo plazo para poder validar el protocolo de terapia no quirúrgico de la periimplantitis

There are multitude of treatment regimens for the peri-implant lesion, including anti-infective therapy, mechanical debridement, and surgical procedure. The laser model, the mechanical devise and the antibiotic regimens varied between studies as the different types of surgical therapies, ressective or regenerative approach. The outcomes following the treatment of peri-implantitis are highly variable and there are no data available to support specific treatment protocols in non-surgical therapy of peri-implantitis. The aim of this review is analyze the literature on non-surgical treatment of peri-implantitis and find the possible indications and the efficacy of this therapy. In peri-implantitis lesions non-surgical therapy was not found to be effective and the adjunctive use of local antiseptic had only limited effects on clinical and microbiological parameters. It is necessary to develop more randomized-controlled clinical studies evaluating treatment protocols of non-surgical therapy of peri-implantitis