RESUMO
In the literature the side-effects and medical complications of tricyclic antidepressants (TCAs), in the medically ill have been extensively reviewed. This study uses a prospective design to examine these issues' questions in an almost solely in-patient C-L population (N = 37) treated with a serotinergic antidepressant (fluoxetine). A first remarkable finding is the fact that 83% of the patients have complaints comparable with the side-effects of the drug, prior to its administration. Second, although the drop-out rates (DO) are comparable with those in earlier studies, in this study DO do not seem to be related to the seriousness of the side-effects of the drug. The more serious side-effects were hyponatremia (N = 1) and gastrointestinal symptoms (N = 3). In contrast to TCAs no psychiatric side-effects have to be reported. Therefore this study suggests that with good medical supervision fluoxetine can be used in the treatment of seriously medically ill patients with depressive co-morbidity.
Assuntos
Antidepressivos/uso terapêutico , Transtorno Depressivo/tratamento farmacológico , Fluoxetina/uso terapêutico , Adulto , Idoso , Antidepressivos/efeitos adversos , Feminino , Fluoxetina/efeitos adversos , Hospitalização , Humanos , Masculino , Pessoa de Meia-Idade , Pacientes Desistentes do TratamentoAssuntos
Antiparkinsonianos/efeitos adversos , Doença de Parkinson/tratamento farmacológico , Transtornos Relacionados ao Uso de Substâncias/etiologia , Idoso , Antiparkinsonianos/administração & dosagem , Antiparkinsonianos/uso terapêutico , Delírio/induzido quimicamente , Quimioterapia Combinada , Feminino , Alucinações/induzido quimicamente , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
According to the literature, electroconvulsive therapy (ECT) is the most effective treatment for lethal catatonia. This article describes a patient with lethal catatonia: treatment by ECT alone was ineffective, whereas continued treatment with ECT in combination with dantrolene sodium led to improvement.
