Psychoendocrinology: arginine vasopressin and resilience in patients with major depressive disorder.

BACKGROUND: There is a burgeoning body of evidence suggesting that arginine vasopressin (AVP) acts as a neuromodulator of the stress response. AVP stimulates the release of adrenocorticotropic hormone, synergistic to corticotropin-releasing hormone, which might explain AVP's role in resilience. Personal hardiness is the bedrock of resilience. Numerous studies have demonstrated elevated plasma levels of AVP in patients with major depressive disorder (MDD), suggesting an etiopathogenetic role as well as a novel therapeutic target. OBJECTIVE: The aim of this study was to examine the relationship between AVP and resilience in patients with MDD and to determine AVP levels in serum of patients with MDD. METHODS: Forty patients with MDD and 40 healthy control subjects were studied using the Dispositional Resilience (Hardiness) Scale by Barton, the Quality of Life Scale, the Social Readjustment Rating Scale, and the Beck Depression Inventory. Biochemical analysis of plasma levels of AVP, using the enzyme-linked immunosorbent assay (ELISA), was performed for all participants. RESULTS: Levels of AVP were statistically significantly elevated in patients with MDD compared with healthy controls. Psychological hardiness was decreased in patients with MDD compared with healthy controls, a finding also statistically significant. There was a negative correlation between plasma AVP level and psychological hardiness. CONCLUSION: AVP and psychological hardiness are negatively correlated, reflecting lower stress resilience. AVP levels are indeed higher in patients struggling with MDD.

Trait emotional intelligence in a sample of Egyptian children with attention deficit hyperactivity disorder.

BACKGROUND: The link between types and severity of attention deficit hyperactivity disorder (ADHD) symptoms and trait emotional intelligence (TEI) is still underinvestigated, especially in children. We aimed to examine the relationship between TEI and ADHD symptoms in a sample of Egyptian children. METHOD: The study included 50 children with ADHD, who were compared on the basis of their TEI and contrasted with 25 matched healthy controls. They were subjected to the Arabic version of the following scales: Connors scale 3rd edition, parent rating form, Kiddie-Schedule for affective disorders and Schizophrenia present and Lifetime Version (K-SADS-PL), Stanford Binet intelligence scale, 4th edition and Trait Emotional Intelligence Child form (TEI) and a semistructured clinical data sheet for sociodemographic data. RESULTS: Using TEI scale, the control group was shown to have higher scores in TEI than cases, there was a high significant difference with regards to eight of nine TEI facets together with the TEI global score. Moreover, the control group significantly outperformed ADHD children with mixed and hyperactive subtypes on TEI global score in all facets except for adaptability. Meanwhile, the inattentive group performed significantly poorer than those in the control group on TEI global score, adaptability, emotional expression, self-motivation and emotion regulation facets. Trait Emotional Intelligence was negatively correlated with four of ADHD symptom groups assessed by Connors test, namely; impulsivity, cognitive, social problem, and emotional liability symptoms. However, Impulsivity was negatively correlated with all the domains of TEI except for adaptability and emotional expression. On the other hand, oppositional symptoms did not show a significant correlation with any of the TEI facets. CONCLUSIONS: Trait emotional intelligence is highly impaired in children with ADHD and emotional deficits are corner stone features of that disorder, low impulsivity facet of TEI is highly correlated with social problems and poor peer relations.

Prevalence and predictors of depression and anxiety among the elderly population living in geriatric homes in Cairo, Egypt.

BACKGROUND: Anxiety and depression are common in the elderly and affect their quality of life. The rates of depression and anxiety are higher among those living in institutional settings and are usually undiagnosed. AIM: The aim of the study was to determine the prevalence and predictors of depression, anxiety and mixed form (i.e. depression and anxiety) in the elderly living at geriatric homes. PARTICIPANTS AND METHODS: A cross-sectional study was conducted on 240 elderly participants from four randomly selected geriatric homes in Cairo. A pretested interview questionnaire was used to collect data. A short version of the Geriatric Depression Scale (GDS-15), the Hamilton Anxiety Scale, the Katz scale for Activity of Daily living, the three-item loneliness scale and the Personal Wellbeing Index Scale were used. RESULTS: The prevalence of depression, anxiety and mixed disorder among the studied group were 37.5, 14.2 and 30%, respectively. Old age and the presence of comorbidities were predictors for depression and/or anxiety. Female sex, a lower social class, insufficient income, partial independence and loneliness feeling are significant predictors for depression. Being married and loneliness feeling are significant predictors for anxiety, whereas the functional status is a significant predictor for mixed depression and anxiety. CONCLUSION AND RECOMMENDATIONS: Depression and/or anxiety were found in more than 80% of the studied group. An older age, female sex, insufficient income, a lower social class, a partially independent functional status, the presence of comorbidities, more frequent loneliness feeling and being married or divorced were found to be significant predictors for these problems. This study reflects the need for the screening of the elderly in geriatric homes for depression and/or anxiety, especially among high-risk groups, and developing interventions to prevent and control such problems.