RESUMO
AIM: To evaluate cardiodynamic changes in response to magnetolaser therapy (MLT) and these changes links with lipid shifts in cell membrane. MATERIAL AND METHODS: The study enrolled 50 patients with effort angina (functional class II-III). Of them, 37 patients were exposed to 10-day courses of MLT, 13 patients were exposed to sham procedures. Before the treatment and 3 months after it measurements were made of lipid peroxidation (LPO) products, structure of erythrocytic membrane and cardiodynamic parameters. RESULTS: MLT resulted in a significant reduction of LPO products, stabilization of cell membrane structure and positive shifts in cardiodynamics. Correlation was found between the above parameters. CONCLUSION: Improvement of inotropic, diastolic functions of the myocardium and abatement of cardiac remodeling in coronary heart disease patients in response to MLT is realized primarily due to structural stabilization of cell membrane lipid biolayer.
Assuntos
Angina Pectoris/radioterapia , Campos Eletromagnéticos , Membrana Eritrocítica/efeitos da radiação , Terapia com Luz de Baixa Intensidade , Função Ventricular Esquerda/efeitos da radiação , Angina Pectoris/diagnóstico por imagem , Angina Pectoris/fisiopatologia , Pressão Sanguínea/fisiologia , Pressão Sanguínea/efeitos da radiação , Ecocardiografia Doppler , Membrana Eritrocítica/metabolismo , Humanos , Peroxidação de Lipídeos/efeitos da radiação , Terapia com Luz de Baixa Intensidade/métodos , Masculino , Pessoa de Meia-Idade , Fosfolipídeos/metabolismo , Resistência Vascular/fisiologia , Resistência Vascular/efeitos da radiação , Função Ventricular Esquerda/fisiologiaRESUMO
AIM: To examine antioxidant and antiarrhythmic activity of carvedilol vs that of standard beta-blocker anaprilin in coronary patients with low left ventricular ejection fraction (LVEF). MATERIAL AND METHODS: The cross-over trial enrolled 50 coronary male patients with LVEF under 45%. Before and after treatment with carvedilol and anaprilin, measurements were made of blood dienic conjugates and malonic dialdehyde, 24-h ECG monitoring was performed. RESULTS: The antioxidant activity of antiarrhythmic effect of carvedilol was significantly higher than that of anaprilin. A correlation was discovered between the number of extrasystoles and blood levels of dienic conjugates. CONCLUSION: Marked antioxidant activity of carvedilol as well as reduced myocardial energy consumption resultant from hemodynamic cardiac unloading due to block of alpha-adrenoreceptors contribute to carvedilol additional antiarrhythmic effect.
