RESUMO
PURPOSE: To present a case of Vogt-Koyanagi-Harada (VKH) associated with type I diabetes mellitus and celiac disease in a 3 year old female. METHODS: We studied a three-year old female who presented with clinical manifestation of VKH and type I Diabetes mellitus and celiac disease. RESULTS: Patient was found to have hyperglycemia with type I diabetes mellitus. Duodenal mucosal biopsy specimen confirmed the diagnosis of celiac disease. Patient's ocular inflammation was treated by topical and systemic corticosteroid and immune-suppressive therapy. Her diabetes mellitus was controlled by insulin and her celiac disease was controlled by gluten-free diet. CONCLUSIONS: The association of VKH with two autoimmune diseases (celiac disease and type I diabetes mellitus) is rare. This case is, to our knowledge, the youngest patient reported with VKH.
Assuntos
Doença Celíaca/complicações , Diabetes Mellitus Tipo 1/complicações , Síndrome Uveomeningoencefálica/etiologia , Doença Celíaca/dietoterapia , Pré-Escolar , Diabetes Mellitus Tipo 1/tratamento farmacológico , Feminino , Glucocorticoides/uso terapêutico , Humanos , Hiperglicemia/diagnóstico , Imunossupressores/uso terapêutico , Insulina/uso terapêutico , Síndrome Uveomeningoencefálica/tratamento farmacológicoRESUMO
BACKGROUND: Optic disc elevation associated with Down syndrome is an uncommon phenomenon and raises the suspicion of an intracranial space-occupying lesion, thus necessitating the consideration of invasive and noninvasive investigations. METHOD OF STUDY: Four patients with Down syndrome and optic disc elevation without an underlying intracranial pathology are reported. Thorough ophthalmological and neuroradiological investigations were performed on each patient. Mild hyperopia occurred in three patients and myopia in one. CONCLUSIONS: We believe that in most Down syndrome patients with disc elevation, fluorescein angiography and/or clinical follow-up may be sufficient.
Assuntos
Síndrome de Down/patologia , Disco Óptico/patologia , Criança , Pré-Escolar , Feminino , Angiofluoresceinografia , Fundo de Olho , Humanos , Pressão Intracraniana , MasculinoRESUMO
Richner-Hanhart syndrome (Tyrosinemia Type II) is an autosomal recessive disorder of amino acid metabolism characterized by ocular changes, painful palmoplantar hyperkeratosis, and mental retardation. Serum tyrosine increases due to tyrosine aminotransferase deficiency resulting in the deposition of tyrosine crystals in the cornea and in corneal inflammation. Patients are often misdiagnosed as having herpes simplex keratitis. We report on a child who presented with bilateral keratitis secondary to Tyrosinemia Type II diagnosed as herpes simplex keratitis.
