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1.
Science ; 312(5772): 410-3, 2006 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-16484452

RESUMO

We present a technique for simultaneous focusing and energy selection of high-current, mega-electron volt proton beams with the use of radial, transient electric fields (10(7) to 10(10) volts per meter) triggered on the inner walls of a hollow microcylinder by an intense subpicosecond laser pulse. Because of the transient nature of the focusing fields, the proposed method allows selection of a desired range out of the spectrum of the polyenergetic proton beam. This technique addresses current drawbacks of laser-accelerated proton beams, such as their broad spectrum and divergence at the source.

2.
Med Phys ; 31(6): 1587-92, 2004 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15259663

RESUMO

Protontherapy is a well-established approach to treat cancer due to the favorable ballistic properties of proton beams. Nevertheless, this treatment is today only possible with large scale accelerator facilities which are very difficult to install at existing hospitals. In this article we report on a new approach for proton acceleration up to energies within the therapeutic window between 60 and 200 MeV by using modern, high intensity and compact laser systems. By focusing such laser beams onto thin foils we obtained on target intensities of 6 x 10(19) W/cm2, which is sufficient to produce a well-collimated proton beam with an energy of up to 10 MeV. These results are in agreement with numerical simulations and indicate that proton energies within the therapeutic window should be obtained in the very near future using such economical and very compact laser systems. Hence, this approach could revolutionize cancer treatment by bringing the "lab to the hospital-rather than the hospital to the lab".


Assuntos
Terapia a Laser , Neoplasias/radioterapia , Terapia com Prótons , Radioterapia de Alta Energia/métodos , Fenômenos Biofísicos , Biofísica , Simulação por Computador , Humanos , Radioterapia Conformacional/instrumentação , Radioterapia Conformacional/métodos , Radioterapia de Alta Energia/instrumentação
3.
Phys Rev E Stat Nonlin Soft Matter Phys ; 66(3 Pt 1): 031402, 2002 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12366112

RESUMO

We use dynamic light scattering (DLS) and fluorescence recovery after pattern photobleaching (FRAPP) to investigate the dynamics of a model transient network made of an oil-in-water droplet microemulsion to which small amounts of a telechelic polymer are added. The DLS correlation functions exhibit three relaxation modes. The two first modes can be interpreted quantitatively in the frame of the classical De Gennes-Brochard theory of DLS in viscoelastic system. The third, slower mode is diffusive and arises from the ternary character (droplets, polymers, and water) of the system. By contrast, the pattern relaxation in FRAPP exhibits a single-, slow-exponential decay with a characteristic time proportional to the squared inverse scattering vector: the corresponding self-diffusion coefficient of the droplets is found to be close to the diffusion coefficient characterizing the third mode in DLS. We interpret these results in terms of the coupled relaxation of the concentration fluctuations of the polymers and the droplets.

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