In vitro dissolution test of tamoxifen citrate preparations.

The Tamoxifen Citrate is available in oral tablet and is highly used as an endocrines therapy for breast cancer. Products from assorted makers bioavailability problems has been associated to the incomplete dissolution of the tablets. We determined the dissolution in vitro of five pharmaceutical preparations of the Tamoxifen Citrate available in the Brazilian market, Novaldex, Tecnotax, Zita, Tamoxifen (TEVA) and Tamoxifeno (PHARMACIA) all containing 10 mg of active drug. The methodology was conducted according to the in vitro dissolution test from USP XXIII. Other test such as mass uniformity, content uniformity and hardness were accomplished seeking to relate physical characteristics with the in vitro dissolution of these preparations. All the formulations presented liberation more than 75% of the active drug in 30 minutes. Any relationship was not observed between the in vitro dissolution, the average weight, the mass uniformity and the hardness of the tablets whereas the liberation was proportional to the tamoxifen citrate content. Although one of the tested products did present a higher dissolution profiles in comparison to the other tested preparation.

[O and C prenylated chalcones with antineoplastic and antibiotic activities isolated from Lonchocarpus neuroscapha Benth]. / Chalconas o- ec-preniladas com atividades antibiótica e antineoplásica, isoladas de Lonchocarpus neuroscapha Benth

In the course of our program on the antimicrobial and antineoplastic substances from higher plants we have studied many flavonoid compounds isolated from root back of Lonchocarpus neuroscapha Benth. In the present paper a slight effect on sarcoma 180 and Ehrlich carcinoma of cordoin, 4-hydroxy-cordoin and 4-hydroxy-derricin, as well as the only observed effect of derricin on sarcoma 180 were observed. The antimicrobial action of four prenylated chalcones, i.e. 4-hydroxy-derricin, 4-hydroxy-lonchocarpin, 4-hydroxy-cordoin and 4-hydroxy-isocordoin is reported.

[Antimicrobial substances of superior plants. 44. Isolation of diterpene acid from Croton aff. argyrophylloides Muell arg. (Euphorbiaceae)]. / Substáncias antimicrobianas de plantas superiores. comunicação XLIV. Isolamento de um ácido diterpènico de Croton aff. argyrophylloides Muell arg. (Euphorbiaceae)

In this paper the authors present the first report concerning the biological effects of a diterpene isolated from Croton aff. argyrophylloides Muell. Arg (Euphorbiaceae). Some biological and physiochemical properties of the antibiotic, named argyrophillic acid, were appreciated in comparison with those presented by cunabic acid, an antibiotic isolated from Icthyothere cunabi. The authors still show the microbial action of the abietic acid and confront it with that of the argyrophilic acid, the new antibiotic here reported.