Residual force enhancement in human skeletal muscles: A systematic review and meta-analysis.

OBJECTIVE: We reviewed and appraised the existing evidence of in vivo manifestations of residual force enhancement in human skeletal muscles and assessed, through a meta-analysis, the effect of an immediate history of eccentric contraction on the subsequent torque capacity of voluntary and electrically evoked muscle contractions. METHODS: Our search was conducted from database inception to May 2020. Descriptive information was extracted from, and quality was assessed for, 45 studies. Meta-analyses and metaregressions were used to analyze residual torque enhancement and its dependence on the angular amplitude of the preceding eccentric contraction. RESULTS: Procedures varied across studies with regards to muscle group tested, angular stretch amplitude, randomization of contractions, time window analyzed, and verbal command. Torque capacity in isometric (constant muscle tendon unit length and joint angle) contractions preceded by an eccentric contraction was typically greater compared to purely isometric contractions, and this effect was greater for electrically evoked muscle contractions than voluntary contractions. Residual torque enhancement differed across muscle groups for the voluntary contractions, with a significant enhancement in torque observed for the adductor pollicis, ankle dorsiflexors, ankle plantar flexors, and knee extensors, but not for the elbow and knee flexors. Meta-regressions revealed that the angular amplitude of the eccentric contraction (normalized to the respective joint's full range of motion) was not associated with the residual torque enhancement observed. CONCLUSION: There is evidence of residual torque enhancement for most, but not all, muscle groups, and residual torque enhancement is greater for electrically evoked than for voluntary contractions. Contrary to our hypothesis, and contrary to generally accepted findings on isolated muscle preparations, residual torque enhancement in voluntary and electrically evoked contractions does not seem to depend on the angular amplitude of the preceding eccentric contraction.

Why do muscles lose torque potential when activated within their agonistic group?

Agonistic muscles lose approximately 20% of their individual torque-generating capacity when activated with their agonistic muscles compared with when stimulated in isolation. In this study, we (1) tested if this loss in torque was accompanied by a corresponding loss in force, thereby testing the potential role of changes in moment arms between conditions; (2) removed all inter-muscular connections between the quadriceps muscles, thus determining the potential role of inter-muscular force transmission; and (3) systematically changed the inter-muscular pressure by performing experiments at different activation/force levels, thereby exploring the possible role of inter-muscular pressure in the loss of torque capacity with simultaneous muscle activation. Experiments were performed in a New Zealand white rabbit quadriceps model (N=5). Torque and force were measured during activation of femoral nerve branches that supply the individual quadriceps muscles while activating these branches simultaneously and in isolation. Regardless of joint angle and inter-muscular connections between muscles, the differences in torque values between the simultaneous and the isolated activation of the quadriceps muscles were also observed for the directly measured force values. Mean differences in simultaneous and isolated muscle activation remained similar between the intact and separated conditions: torque difference 21±5% of maximum isometric torque of intact condition (MICtorque), versus 19±6% MICtorque, respectively, and force difference 18±3% MICforce versus 19±7% MICforce, respectively. The absolute torque loss was independent of the force, and thus presumably the inter-muscular pressures. Based on these results, we conclude that the torque deficit observed during simultaneous compared with isolated muscle activation is not primarily caused by moment arm, inter-muscular pressure or inter-muscular force transmission. The mechanisms underlying loss of force capacity during agonistic muscle contraction remain unknown.

Predictors of residual force enhancement in voluntary contractions of elbow flexors.

BACKGROUND: The steady-state increase in muscle force generating potential following a lengthening contraction is called residual force enhancement (RFE). In this study, we aimed to test for differences in torque, electromyographic activity (EMG), and the associated neuromuscular efficiency (NME) between isometric voluntary contractions of elbow flexors preceded and not preceded by a lengthening contraction. The dependence of such differences on (i) stretch amplitude, (ii) the region of the force-length (FxL) relationship where contraction occurs, and (iii) the individual's ability to produce (negative) work during the stretch was investigated. METHODS: Sixteen healthy adults participated in the study. Elbow flexor torque, angle, and biceps brachii EMG for purely isometric contractions (reference contractions) and for isometric contractions preceded by active stretches of 20° and 40° were measured at the ascending, plateau, and descending regions of subject-specific FxL curves. All contractions were performed in an isokinetic dynamometer. Two-factor (stretch × FxL region) repeated measures analysis of variance ANOVAs was used to analyze the effect of active stretch on EMG, torque, and NME across conditions. The relationships between mechanical work during stretch-calculated as the torque-angular displacement integral-and the changes in EMG, torque, and NME were analyzed using Pearson correlation. RESULTS: In general, torque, EMG, and NME following active stretches differed from the values observed for the purely isometric reference contractions. While although the detailed effects of active stretch on torque and EMG differed between regions of the FxL relationship, NME increased by about 19% for all muscle lengths. Up to 30% of the interindividual variability in torque generating potential change in response to active stretching was accounted for by differences in (negative) work capacity between subjects. CONCLUSION: Our results suggest that (i) RFE contributes to "flatten" the elbow flexor torque-angle relationship, favoring torque production at lengths where the purely isometric torques are reduced substantially, and (ii) RFE contributes to a reduction in energy cost of torque production during isometric contractions for the entire operating range.