Perfil epidemiológico de pacientes portadores de câncer de pele atendidos no Hospital Regional da Asa Norte/DF - Brasil / Epidemiological profile of patients with skin cancer treated at the Regional Hospital of Asa Norte/DF - Brazil

Introdução: O câncer de pele é a neoplasia mais comum na população brasileira, correspondendo a 30% de todos os tumores malignos registrados no país. Os tumores malignos não melanoma são o tipo de câncer de maior incidência e prevalência no Brasil. O carcinoma basocelular (CBC) é o mais comum, correspondendo entre 70% e 75% dos casos. O carcinoma epidermóide (CEC) responde por 20% dos casos. O objetivo é determinar o perfil epidemiológico, os tipos e subtipos encontrados nos resultados de histopatológico, a conduta cirúrgica e sua eficácia, dos pacientes com suspeita de lesão maligna de pele. Métodos: Estudo retrospectivo descritivo, baseado na análise de prontuário eletrônico de ressecção de lesões de pele suspeitas de maligna, pela equipe da Cirurgia Plástica do Hospital Regional da Asa Norte, Brasília/DF, no período de janeiro de 2012 a dezembro de 2016. Resultados: Foram submetidos à cirurgia 533 pacientes, sendo sexo feminino (51,6%), com média de idade de 68,97 anos e 84% com diagnóstico de carcinoma basocelular com subtipo sólido. As margens comprometidas atingiram 11% da amostra. As reconstruções mais prevalentes foram fechamento primário e retalhos locais. Conclusão: O perfil epidemiológico dos pacientes atendidos com lesões suspeitas de câncer de pele demonstrou prevalência em mulheres e acima de 60 anos, com história de exposição solar. A face foi o local mais acometido, sendo o nariz a topografia mais comum. O CBC é tipo mais comum e o subtipo sólido circunscrito foi o mais prevalente. O tipo de reconstrução mais utilizado foi o fechamento primário e o retalho local.

Introduction: Skin cancer is the most common neoplasm in the Brazilian population, corresponding to 30% of all malignant tumors registered in the country. Non-melanoma malignant tumors are the type of cancer with the highest incidence and prevalence in Brazil. Basal cell carcinoma (BCC) is the most common, accounting for between 70% and 75% of cases. Squamous cell carcinoma (SCC) accounts for 20% of cases. The objective is to determine the epidemiological profile, the types and subtypes found in the histopathological results, the surgical conduct and its effectiveness in patients with a suspected malignant skin lesion. Methods: A retrospective descriptive study, based on the analysis of electronic medical records for resection of skin lesions suspected of malignancy, carried out by the Plastic Surgery team at the Regional Hospital of Asa Norte, Brasília/DF, from January 2012 to December 2016. Results: 533 patients were submitted to surgery, being female (51.6%), with a mean age of 68.97 years and 84% diagnosed with basal cell carcinoma with solid subtype. The compromised margins reached 11% of the sample. The most prevalent reconstructions were primary closure and local flaps. Conclusion: The epidemiological profile of patients treated with lesions suspected of skin cancer showed prevalence in women over 60 years with a history of sun exposure. The face was the most affected site, the nose being the most common topography. BCC is the most common type, and the circumscribed solid subtype was the most prevalent. The most used type of reconstruction was primary closure and local flap.

What Is the Impact of Residual Obesity on the Risk for Postoperative Body-Contouring Surgery Complications in Postbariatric Patients?

BACKGROUND: There are an increasing number of patients presenting for plastic surgery after massive weight loss, and many of these patients have residual obesity that may compromise outcomes. The impact of residual obesity on the development of postoperative complications in postbariatric patients undergoing plastic surgery procedures is unclear. METHODS: We report the outcomes of 207 patients who underwent plastic surgery following RYGB from January 2011 to December 2018. RESULTS: Two hundred and seven patients (196 females, 11 males) with a mean age of 42 years underwent 335 separate operations. The average BMI at the time of plastic surgery was 27.43 kg/m2. The average weight loss was 47.08 kg. The prevalence of comorbidities was 26.6% and the most important presurgery comorbidities were arterial hypertension (10.1%) and diabetes mellitus (4.8%). Of the 207 patients who underwent surgery, 78.3% (168/207) underwent abdominoplasty and 45.0% underwent mammoplasty. The overall rate of complications was 27.5%. The prevalence of postoperative complications was not significantly different between patients with a BMI ≥ 30 kg/m2 and patients with a BMI < 30 kg/m2 (33.3% vs 25.9%, respectively; p = 0.344). CONCLUSION: In this group of patients, with specified anthropometric and clinical profiles, the residual obesity did not influence the incidence of postoperative complications in postbariatric patients after plastic surgery.

What Is the Impact of Comorbidities on the Risk for Postoperative Body-Contouring Surgery Complications in Postbariatric Patients?

BACKGROUND: There is an increasing number of patients presenting after massive weight loss for plastic surgery, and many of these patients have residual diseases that may compromise outcomes. This study aims to evaluate the impact of comorbidities on the development of postoperative complications in postbariatric patients undergoing plastic surgery procedures at the Federal District North Wing Regional Hospital, Brasília, Brazil. METHODS: Descriptive, analytical, and prospective study was performed on patients who underwent plastic surgery following RYGB from January 2011 to December 2016. Measures included BMI (body mass index) before RYGB and before plastic surgery, medical complications and comorbidities. RESULTS: One hundred thirty-nine patients (130 female, 9 male) with a mean age of 41 years underwent 233 separate operations. The average BMI at the time of plastic surgery was 27.44 kg/m2. The average weight loss was 47.02 kg, and the mean pre-weight-loss BMI (max BMI) was 45.17 kg/m2. The most important pre-plastic comorbidities were arterial hypertension (11.5%), degenerative arthropathy (5.4%), diabetes mellitus (5.0%), and metabolic syndrome (4.3%). Of the 139 patients operated upon, 76.97% underwent abdominoplasty followed by mammoplasty (42.46%). The overall rate of complications was 26.65%. Initially, on univariate regression analyses, comorbidities influenced the development of postoperative complications. However, after multiple logistic regression, the most important comorbidities failed to predict an increased risk of complications. CONCLUSION: In this group of patients, with these anthropometric and clinical profiles, the most important comorbidities (diabetes, arterial hypertension, and metabolic syndrome) failed to influence the incidence of postoperative complications in postbariatric patients after plastic surgery.

[Interval for access to treatment for breast cancer in the Federal District, Brazil]. / Tempo para acesso ao tratamento do câncer de mama no Distrito Federal, Brasil Central.

PURPOSE: To analyze the time between the first symptom and treatment in patients treated for breast cancer in public hospitals in the Federal District. METHODS: This was a cross-sectional analysis. We interviewed 250 women diagnosed with breast cancer treated in six hospitals of the State Department of Health of the Federal District from November 2009 to January 2011. The time intervals studied were the time between the detection of the symptoms and treatment subdivided into intervals until and after the first medical appointment. The variables were: age, menopausal status, color, educational level, average monthly household income, origin, reason for the initial consultation, staging, tumor size, laterality, metastasis to axillary lymph nodes, neoadjuvant chemotherapy, and type of surgery. The Mann-Whtney test was used to assess the association of these variables with the time intervals until treatment. RESULTS: The mean age was 52 years, with a predominance of white women (57.6%), from the Federal District (62.4%), with a family income of up to 2 minimum wages (78%), and up to four years of schooling (52.4%). The staging of the disease ranged from II to IV in 78.8% of the women. The time between the first symptom and treatment was 229 days (median). After detection of the first symptom, 52.9% of the women attended a consultation within 30 days and 88.8% took more than 90 days to start treatment. Women with elementary school education had a greater delay to the start of treatment (p=0.049). CONCLUSIONS: There was a significant delay to start treatment of women with breast cancer in public hospitals of the Federal District, suggesting that efforts should be made to reduce the time needed to schedule medical appointments and to diagnose and treat these patients.

Self-inflicted burns: attempted suicide.

OBJECTIVE: To analyze the incidence, characteristics, behavior and mortality rate of patients with self-injury by burns admitted to the Burns Centre of Brasilia, Federal District, Brazil. METHODS: The study population consisted of burned patients consecutively admitted to the Burns Unit of Hospital Regional da Asa Norte, Brasília, Federal District, Brazil, during the period from February 2008 to February 2009. Data were obtained on admission and were prospectively recorded during hospitalization. Patients were followed until discharge or death. RESULTS: During the study period, 15 cases were admitted due to self-injury burns in the Unit. The mean age was 38.0 ± 20.6 years, 66.7% of cases of self-injury burning were women. In most cases they were married, home providers and poor. The biggest reason was marital conflict. The mortality rate was 40%. The average burned body surface was 38.7 ± 26.1%. Alcohol was used by 66.7% of patients to cause the burns. The average duration of treatment was 20.1 ± 14.8 days. Self-injury burned patients had more extensive lesions, remained in hospital for longer periods and had worse prognosis. CONCLUSION: Patients with self-inflicted burns had a mean higher age, higher burned body surface, longer hospitalization, more infectious complications and higher mortality rate than patients with accidental burns. These patients need constant psychiatric support, which can be helpful in preventing future episodes of self-harm.

An experimental study of tissue reaction to polymethyl methacrylate (PMMA) microspheres (Artecoll) and dimethylsiloxane (DMS) in the mouse.

Various methods are available for the treatment of scars, wrinkles, and other cutaneous defects, and the material used must be as biocompatible as possible. This study analyzes the biological behavior of polymethyl methacrylate/bovine collagen (Artecoll) and of polydimethylsiloxane (DMS), using a histopathological study in mice. A prospective study was performed using 40 mice for each substance: polymethyl methacrylate/bovine collagen or polydimethylsiloxane was injected into the right ear, the left ear being used as a control. Histopathological analyses of the right ear, liver, and kidney were performed at intervals during the study and revealed the development of an intense granulomatous reaction of the foreign body type in the right ear, periportal and intralobular infiltrates in the liver, and interstitial nephritis and chronic pyelonephritis in the kidney for polymethyl methacrylate/bovine collagen. A variable reaction with less intense fibrosis and a reduced foreign body reaction were seen in the mice injected with polydimethylsiloxane.

Bacterial and fungal colonization of burn wounds.

A prospective study of fungal and bacterial flora of burn wounds was carried out from February 2004 to February 2005 at the Burns Unit of Hospital Regional da Asa Norte, Brasília, Brazil. During the period of the study, 203 patients were treated at the Burns Unit. Wound swab cultures were assessed at weekly intervals for four weeks. Three hundred and fifty four sampling procedures (surface swabs) were performed from the burn wounds. The study revealed that bacterial colonization reached 86.6% within the first week. Although the gram-negative organisms, as a group, were more predominant, Staphylococcus aureus (28.4%) was the most prevalent organism in the first week. It was however surpassed by Pseudomonas aeruginosa form third week onwards. For S. aureus and P. aeruginosa vancomycin and polymyxin were found to be the most effective drugs. Most of the isolates showed high level resistance to antimicrobial agents. Fungi were found to colonize the burn wound late during the second week postburn, with a peak incidence during the third and fourth weeks. Species identification of fungi revealed that Candida tropicalis was the most predominant, followed by Candida parapsilosis. It is crucial for every burn institution to determine the specific pattern of burn wound microbial colonization, the time-related changes in the dominant flora, and the antimicrobial sensitivity profiles. This would enable early treatment of imminent septic episodes with proper empirical systemic antibiotics, without waiting for culture results, thus improving the overall infection-related morbidity and mortality.