RESUMO
Molluscum contagiosum (MC) is a contagious disease caused by a virus of the poxvirus family. In children, the disease commonly manifests as a variable number of discrete umbilicated papules on the face and trunk. In healthy and immunosuppressed adults, the disease appears on or near the genital organs and is often sexually transmitted. MC involving the intraoral mucosa has been documented but is rare. We report a case of MC involving the oral mucosa exclusively and discuss the main clinical, histopathologic, and therapeutic characteristics, comparing the findings with cases of this rare oral presentation described in the literature.
Assuntos
Molusco Contagioso/diagnóstico , Mucosa Bucal/virologia , Adolescente , Diagnóstico Diferencial , Feminino , HumanosRESUMO
OBJECTIVE: To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. STUDY DESIGN: Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13). RESULTS: Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. CONCLUSION: The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue.
Assuntos
Carcinoma de Células Escamosas/patologia , Neoplasias Labiais/patologia , Metaloproteinases da Matriz/análise , Neoplasias da Língua/patologia , Núcleo Celular/ultraestrutura , Progressão da Doença , Humanos , Imuno-Histoquímica , Inflamação/patologia , Queratinas/análise , Metaloproteinase 1 da Matriz/análise , Metaloproteinase 2 da Matriz/análise , Metaloproteinase 7 da Matriz/análise , Metaloproteinase 9 da Matriz/análise , Metaloproteinases da Matriz Secretadas/análise , Invasividade Neoplásica , Células Estromais/patologiaRESUMO
Partial facial hemihyperplasia is a rare maxillofacial dysmorphosis of debatable etiology, and is frequently associated with relatively serious appearance and functional disorders depending on the degree of hyperplasia. We report here a case of partial facial hemihyperplasia with 9 years of evolution, describing the alterations observed during the follow-up period and discussing the main aspects of this poorly known entity.
